The prevalence and clinical implications of pancreatic fat accumulation identified during a medical check-up.
Adult
Aged
Amylases
/ blood
Blood Glucose
Cholesterol, LDL
/ blood
Cross-Sectional Studies
Fatty Liver
/ epidemiology
Female
Humans
Intra-Abdominal Fat
/ diagnostic imaging
Japan
/ epidemiology
Life Style
Male
Metabolic Diseases
/ diagnosis
Middle Aged
Pancreas
/ pathology
Pancreatic Diseases
/ complications
Phenotype
Physical Examination
/ standards
Prevalence
Severity of Illness Index
Triglycerides
/ blood
Ultrasonography
/ methods
Waist Circumference
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
15 Oct 2021
15 Oct 2021
Historique:
received:
19
05
2021
accepted:
15
09
2021
entrez:
3
11
2021
pubmed:
4
11
2021
medline:
16
11
2021
Statut:
ppublish
Résumé
Fatty pancreas (FP) is characterized by pancreatic fat accumulation and the subsequent development of pancreatic and metabolic complications. However, FP has not been categorized in the manual for abdominal ultrasound in cancer screening and health check-ups in Japan, and the pathology of FP has not been fully elucidated.Nine hundred and nineteen people who underwent a medical check-up had the severity of their pancreatic fat accumulation categorized after transabdominal ultrasonographic examination. The relationships between FP, lifestyle-related diseases, and fatty liver disease at this time were assessed using stratification analysis.The prevalence of FP was 46.8% (430/919). People with FP were more likely to be male and had higher prevalences of lifestyle-related diseases, including fatty liver disease. Men and women were similarly represented in each tertile of pancreas brightness. Older age; high waist circumference, triglyceride and glucose index, serum low-density lipoprotein-cholesterol, hepatic steatosis index; and low serum amylase were associated with the presence of severe FP. Moreover, the group with severe liver steatosis had a higher prevalence of FP and a higher pancreatic brightness score. Logistic regression analysis showed that individuals with liver steatosis were more likely to have severe FP.The severity of FP is associated with features of lifestyle-related diseases and the severity of liver steatosis. These findings suggest that high visceral fat content is associated with more severe fatty pancreas as a phenotype of ectopic fat accumulation, as well as fatty liver disease.
Identifiants
pubmed: 34731128
doi: 10.1097/MD.0000000000027487
pii: 00005792-202110150-00028
pmc: PMC8519203
doi:
Substances chimiques
Blood Glucose
0
Cholesterol, LDL
0
Triglycerides
0
Amylases
EC 3.2.1.-
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e27487Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP18K07930
Organisme : Japan Society for the Promotion of Science
ID : JP18H03172
Organisme : Japan Society for the Promotion of Science
ID : JP19K08460
Organisme : Japan Society for the Promotion of Science
ID : JP20H04119
Organisme : Japan Society for the Promotion of Science
ID : JP20K08275
Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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