Ripple band phase precession of place cell firing during replay.
hippocampus
phase coding
place cells
replay
sharp-wave ripples
theta oscillations
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
23
04
2021
revised:
06
09
2021
accepted:
14
10
2021
pubmed:
4
11
2021
medline:
12
4
2022
entrez:
3
11
2021
Statut:
ppublish
Résumé
Neuronal "replay," in which place cell firing during rest recapitulates recently experienced trajectories, is thought to mediate the transmission of information from hippocampus to neocortex, but the mechanism for this transmission is unknown. Here, we show that replay uses a phase code to represent spatial trajectories by the phase of firing relative to the 150- to 250-Hz "ripple" oscillations that accompany replay events. This phase code is analogous to the theta phase precession of place cell firing during navigation, in which place cells fire at progressively earlier phases of the 6- to 12-Hz theta oscillation as their place field is traversed, providing information about self-location that is additional to the rate code and a necessary precursor of replay. Thus, during replay, each ripple cycle contains a "forward sweep" of decoded locations along the recapitulated trajectory. Our results indicate a novel encoding of trajectory information during replay and implicates phase coding as a general mechanism by which the hippocampus transmits experienced and replayed sequential information to downstream targets.
Identifiants
pubmed: 34731677
pii: S0960-9822(21)01422-6
doi: 10.1016/j.cub.2021.10.033
pmc: PMC8751637
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-73.e5Subventions
Organisme : Wellcome Trust
ID : 202805/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 212281/Z/18/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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