Distributed and Localized Dynamics Emerge in the Mouse Neocortex during Reach-to-Grasp Behavior.
calcium imaging
functional connectivity
neocortex
neural dynamics
reach-to-grasp
voluntary movement
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
02 02 2022
02 02 2022
Historique:
received:
06
04
2020
revised:
25
05
2021
accepted:
18
08
2021
pubmed:
5
11
2021
medline:
16
2
2022
entrez:
4
11
2021
Statut:
ppublish
Résumé
A long-standing question in systems neuroscience is to what extent task-relevant features of neocortical processing are localized or distributed. Coordinated activity across the neocortex has been recently shown to drive complex behavior in the mouse, while activity in selected areas is canonically associated with specific functions (e.g., movements in the case of the motor cortex). Reach-to-grasp (RtG) movements are known to be dependent on motor circuits of the neocortex; however, the global activity of the neocortex during these movements has been largely unexplored in the mouse. Here, we characterized, using wide-field calcium imaging, these neocortex-wide dynamics in mice of either sex engaging in an RtG task. We demonstrate that, beyond motor regions, several areas, such as the visual and the retrosplenial cortices, also increase their activity levels during successful RtGs, and homologous regions across the ipsilateral hemisphere are also involved. Functional connectivity among neocortical areas increases transiently around movement onset and decreases during movement. Despite this global phenomenon, neural activity levels correlate with kinematics measures of successful RtGs in sensorimotor areas only. Our findings establish that distributed and localized neocortical dynamics co-orchestrate efficient control of complex movements.
Identifiants
pubmed: 34732524
pii: JNEUROSCI.0762-20.2021
doi: 10.1523/JNEUROSCI.0762-20.2021
pmc: PMC8808729
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
777-788Informations de copyright
Copyright © 2022 the authors.
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