The Associations between Blood and Urinary Concentrations of Metal Metabolites, Obesity, Hypertension, Type 2 Diabetes, and Dyslipidemia among US Adults: NHANES 1999-2016.
Journal
Journal of environmental and public health
ISSN: 1687-9813
Titre abrégé: J Environ Public Health
Pays: United States
ID NLM: 101516361
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
04
2021
revised:
02
10
2021
accepted:
06
10
2021
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Heavy metals are well known to be associated with cancer outcomes, but its association with obesity and cardiometabolic risk outcomes requires further study. Adult data from the National Health and Examination Survey (NHANES Continuous 1999-2016, Blood lead had a negative linear association with obesity (odds ratio (OR) = 0.42, 95% confidence interval (CI) = 0.37-0.47). In those with obesity, high blood lead was associated with lower risk of prevalent dyslipidemia, while no association was found in those without obesity. The study observed a curvilinear relationship between urinary antimony and obesity with the moderate group having the highest odds of obesity (OR = 1.36, 1.16-1.59). However, the relationship between urinary antimony and prevalent hypertension and dyslipidemia risk was linear, positive, and independent of obesity. While not associated with prevalent obesity risk, high urinary uranium was associated with 30% ( The impact of environmental factors on obesity and health may be complex, and this study reinforces the heterogeneous relationship between various metals, obesity, and obesity-related metabolic diseases even at levels observed in the general population.
Sections du résumé
Background
Heavy metals are well known to be associated with cancer outcomes, but its association with obesity and cardiometabolic risk outcomes requires further study.
Methods
Adult data from the National Health and Examination Survey (NHANES Continuous 1999-2016,
Results
Blood lead had a negative linear association with obesity (odds ratio (OR) = 0.42, 95% confidence interval (CI) = 0.37-0.47). In those with obesity, high blood lead was associated with lower risk of prevalent dyslipidemia, while no association was found in those without obesity. The study observed a curvilinear relationship between urinary antimony and obesity with the moderate group having the highest odds of obesity (OR = 1.36, 1.16-1.59). However, the relationship between urinary antimony and prevalent hypertension and dyslipidemia risk was linear, positive, and independent of obesity. While not associated with prevalent obesity risk, high urinary uranium was associated with 30% (
Conclusions
The impact of environmental factors on obesity and health may be complex, and this study reinforces the heterogeneous relationship between various metals, obesity, and obesity-related metabolic diseases even at levels observed in the general population.
Identifiants
pubmed: 34733334
doi: 10.1155/2021/2358060
pmc: PMC8560296
doi:
Substances chimiques
Metals, Heavy
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2358060Informations de copyright
Copyright © 2021 Sarah Swayze et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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