Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study.
Endoscopic surgery
Gastrointestinal endoscope
Gastrointestinal imaging
Head and neck imaging
Hypopharyngeal neoplasm
Oropharyngeal neoplasm
Journal
World journal of gastrointestinal endoscopy
ISSN: 1948-5190
Titre abrégé: World J Gastrointest Endosc
Pays: United States
ID NLM: 101532474
Informations de publication
Date de publication:
16 Oct 2021
16 Oct 2021
Historique:
received:
06
03
2021
revised:
26
07
2021
accepted:
16
09
2021
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
5
11
2021
Statut:
ppublish
Résumé
In recent years, with the growing availability of image-enhanced gastrointestinal endoscopy, gastroenterologists have contributed to the early detection of pharyngeal squamous cell carcinomas (SCC). To clarify the clinical characteristics of pharyngeal SCCs detected by gastrointestinal endoscopy. This is a retrospective cohort study conducted in a single-center, a university hospital in Japan. We retrospectively assessed the clinical records of 522 consecutive patients with oropharyngeal or hypopharyngeal SCC who were examined in our hospital between 2011 and 2018. The lesions were classified into two groups: Group GE (detected by gastrointestinal endoscopy) and Group non-GE (detected by means other than gastrointestinal endoscopy). The clinical characteristics were compared between the two groups. Continuous data were compared using the Mann-Whitney In our study group, the median age was 65 years and 474 patients (90.8%) were male. One hundred and ninety-six cases (37.5%) involved the oropharynx and 326 cases (62.5%) involved the hypopharynx. Three hundred and ninety-five cases (75.7%) had some symptoms at the time of diagnosis. One hundred and forty-five (27.8%) cases had concurrent ESCC or a history of ESCC. One hundred and sixty-four (31.4%) cases were detected by gastrointestinal endoscopy and classified as Group GE. The proportions of asymptomatic cases, cTis-1 cases and cases with no lymph node metastasis were significantly higher in Group GE than Group non-GE (61.6% Gastrointestinal endoscopy plays an important role in the early detection and improving the prognosis of pharyngeal SCCs.
Sections du résumé
BACKGROUND
BACKGROUND
In recent years, with the growing availability of image-enhanced gastrointestinal endoscopy, gastroenterologists have contributed to the early detection of pharyngeal squamous cell carcinomas (SCC).
AIM
OBJECTIVE
To clarify the clinical characteristics of pharyngeal SCCs detected by gastrointestinal endoscopy.
METHODS
METHODS
This is a retrospective cohort study conducted in a single-center, a university hospital in Japan. We retrospectively assessed the clinical records of 522 consecutive patients with oropharyngeal or hypopharyngeal SCC who were examined in our hospital between 2011 and 2018. The lesions were classified into two groups: Group GE (detected by gastrointestinal endoscopy) and Group non-GE (detected by means other than gastrointestinal endoscopy). The clinical characteristics were compared between the two groups. Continuous data were compared using the Mann-Whitney
RESULTS
RESULTS
In our study group, the median age was 65 years and 474 patients (90.8%) were male. One hundred and ninety-six cases (37.5%) involved the oropharynx and 326 cases (62.5%) involved the hypopharynx. Three hundred and ninety-five cases (75.7%) had some symptoms at the time of diagnosis. One hundred and forty-five (27.8%) cases had concurrent ESCC or a history of ESCC. One hundred and sixty-four (31.4%) cases were detected by gastrointestinal endoscopy and classified as Group GE. The proportions of asymptomatic cases, cTis-1 cases and cases with no lymph node metastasis were significantly higher in Group GE than Group non-GE (61.6%
CONCLUSION
CONCLUSIONS
Gastrointestinal endoscopy plays an important role in the early detection and improving the prognosis of pharyngeal SCCs.
Identifiants
pubmed: 34733409
doi: 10.4253/wjge.v13.i10.491
pmc: PMC8546562
doi:
Types de publication
Journal Article
Langues
eng
Pagination
491-501Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare no conflicts of interest associated with this manuscript.
Références
Int J Clin Oncol. 2017 Oct;22(5):826-833
pubmed: 28501947
Dig Endosc. 2018 Jul;30(4):516-521
pubmed: 29637617
United European Gastroenterol J. 2019 Dec;7(10):1304-1311
pubmed: 31839955
Head Neck. 2013 Sep;35(9):1248-54
pubmed: 22941930
Dig Endosc. 2013 Mar;25 Suppl 1:39-43
pubmed: 23480401
World J Gastroenterol. 2017 Feb 14;23(6):1051-1058
pubmed: 28246479
Gastrointest Endosc. 2015 Apr;81(4):985-8
pubmed: 25440288
Gastrointest Endosc. 2015 Dec;82(6):1002-8
pubmed: 26234696
Otolaryngol Head Neck Surg. 2001 May;124(5):561-9
pubmed: 11337663
Head Neck. 1998 Dec;20(8):714-9
pubmed: 9790293
Surg Endosc. 2016 Jan;30(1):323-9
pubmed: 25917165
Gastroenterology. 2016 Nov;151(5):860-869.e7
pubmed: 27492616
Endosc Int Open. 2016 Jul;4(7):E752-5
pubmed: 27556090
Endoscopy. 2011 Oct;43(10):839-43
pubmed: 21833903
Endoscopy. 2010 Mar;42(3):185-90
pubmed: 20195988
J Gastroenterol Hepatol. 2010 Feb;25(2):264-9
pubmed: 19874445
Gastroenterol Res Pract. 2016;2016:6140854
pubmed: 27738428
Viruses. 2015 Mar 20;7(3):1332-43
pubmed: 25803099
Cancer. 1953 Sep;6(5):963-8
pubmed: 13094644
Int J Clin Oncol. 2016 Oct;21(5):827-835
pubmed: 27380170
J Clin Oncol. 2010 Mar 20;28(9):1566-72
pubmed: 20177025
Auris Nasus Larynx. 2020 Feb;47(1):135-140
pubmed: 31153665