Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
Animals
Bacterial Load
Cell Membrane
/ metabolism
Cell Membrane Permeability
Cornified Envelope Proline-Rich Proteins
/ genetics
Cytokines
/ metabolism
Disease Susceptibility
Gastrointestinal Microbiome
Goblet Cells
/ metabolism
Gram-Positive Bacteria
/ physiology
Humans
Immunity, Innate
Intestinal Mucosa
/ metabolism
Intestines
/ microbiology
Listeria monocytogenes
/ physiology
Listeriosis
/ microbiology
Mice
Microbial Viability
Nematospiroides dubius
Paneth Cells
/ metabolism
Pore Forming Cytotoxic Proteins
/ genetics
Strongylida Infections
/ immunology
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
05 Nov 2021
05 Nov 2021
Historique:
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
16
11
2021
Statut:
ppublish
Résumé
A diverse group of antimicrobial proteins (AMPs) helps protect the mammalian intestine from varied microbial challenges. We show that small proline-rich protein 2A (SPRR2A) is an intestinal antibacterial protein that is phylogenetically unrelated to previously discovered mammalian AMPs. In this study, SPRR2A was expressed in Paneth cells and goblet cells and selectively killed Gram-positive bacteria by disrupting their membranes. SPRR2A shaped intestinal microbiota composition, restricted bacterial association with the intestinal surface, and protected against
Identifiants
pubmed: 34735226
doi: 10.1126/science.abe6723
pmc: PMC8977106
mid: NIHMS1788060
doi:
Substances chimiques
Cornified Envelope Proline-Rich Proteins
0
Cytokines
0
Pore Forming Cytotoxic Proteins
0
SPRR2A protein, human
0
Sprr2a1 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabe6723Subventions
Organisme : NIDDK NIH HHS
ID : K99 DK120897
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK070855
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR076459
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130020
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI005284
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK120897
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Références
Science. 2016 Apr 29;352(6285):608-12
pubmed: 27080105
Cell Mol Life Sci. 2011 Jul;68(13):2317-30
pubmed: 21594684
Cell. 2012 Mar 16;148(6):1258-70
pubmed: 22424233
Immunity. 2015 Jan 20;42(1):28-39
pubmed: 25607457
Nat Rev Immunol. 2012 Jun 25;12(7):503-16
pubmed: 22728527
Science. 2001 Feb 2;291(5505):881-4
pubmed: 11157169
Curr Protoc Immunol. 2003 Aug;Chapter 19:Unit 19.12
pubmed: 18432905
Trends Parasitol. 2010 Nov;26(11):524-9
pubmed: 20729145
BMC Genomics. 2006 Jan 18;7:9
pubmed: 16420688
Infect Immun. 2004 Oct;72(10):6076-86
pubmed: 15385512
Methods Enzymol. 2002;356:167-96
pubmed: 12418197
Nat Rev Immunol. 2011 Jun;11(6):375-88
pubmed: 21610741
Science. 2006 Aug 25;313(5790):1126-30
pubmed: 16931762
Nature. 2019 May;569(7757):503-508
pubmed: 31068700
Trends Immunol. 2018 Sep;39(9):724-733
pubmed: 29941203
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11027-11033
pubmed: 28973871
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23643-23652
pubmed: 31672911
Immunity. 1996 Mar;4(3):313-9
pubmed: 8624821
Nat Rev Immunol. 2013 Aug;13(8):607-14
pubmed: 23827958
Science. 2011 Oct 14;334(6053):255-8
pubmed: 21998396
Mucosal Immunol. 2018 Mar;11(2):304-315
pubmed: 29297502
Science. 2017 Sep 1;357(6354):912-916
pubmed: 28860383
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9
pubmed: 18806221
PLoS Genet. 2011 Feb;7(2):e1001314
pubmed: 21379339
Nat Rev Immunol. 2003 Sep;3(9):733-44
pubmed: 12949497
Cell Host Microbe. 2017 Oct 11;22(4):484-493.e5
pubmed: 29024642
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6676-81
pubmed: 8692877
J Vis Exp. 2015 Apr 06;(98):e52412
pubmed: 25867600
Cell Host Microbe. 2019 Jun 12;25(6):777-788.e8
pubmed: 31101494
Science. 2019 Sep 27;365(6460):1428-1434
pubmed: 31604271
Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40
pubmed: 15803139
Genomics. 1993 Jun;16(3):630-7
pubmed: 8325635
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13596-600
pubmed: 15340149
Immunity. 1998 Jul;9(1):143-50
pubmed: 9697844
Science. 2019 May 24;364(6442):787-792
pubmed: 31123136
Dig Dis Sci. 2003 May;48(5):976-85
pubmed: 12772799
Nature. 2011 Jan 20;469(7330):415-8
pubmed: 21113151
Nature. 2017 Nov 16;551(7680):333-339
pubmed: 29144463
Pharmaceuticals (Basel). 2016 Nov 01;9(4):
pubmed: 27809281
Exp Parasitol. 2007 Aug;116(4):458-66
pubmed: 17420014
Nature. 2002 Jan 24;415(6870):389-95
pubmed: 11807545
Immunol Rev. 2014 Jul;260(1):8-20
pubmed: 24942678
Nature. 2014 Jan 2;505(7481):103-7
pubmed: 24256734
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1292-7
pubmed: 12552104
Trends Parasitol. 2020 Sep;36(9):761-772
pubmed: 32713764
J Infect Dis. 2002 Jul 1;186(1):8-14
pubmed: 12089656
Nat Immunol. 2003 Mar;4(3):269-73
pubmed: 12548285