Is Myelodysplasia a Consequence of Normal Aging?
Aging
CHIP
Clonality
Elderly
Myelodysplastic syndromes
Myeloid neoplasia
Journal
Current oncology reports
ISSN: 1534-6269
Titre abrégé: Curr Oncol Rep
Pays: United States
ID NLM: 100888967
Informations de publication
Date de publication:
04 11 2021
04 11 2021
Historique:
accepted:
27
07
2021
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
19
2
2022
Statut:
epublish
Résumé
To review available data on the relationship of MDS and aging and to address the question if biological changes of (premature) aging are a prerequisite for the development of MDS. Whereas the association of MDS with advanced age and some common biologic features of aging and MDS are well established, additional evidence for both, especially on the role of stem cells, the stem cell niche, and inflammation, has been recently described. Biologically, many but not all drivers of aging also play a role in the development and propagation of MDS and vice versa. As a consequence, aging contributes to the development of MDS which can be seen as an interplay of clonal disease and normal and premature aging. The impact of aging may be different in specific MDS subtypes and risk groups.
Identifiants
pubmed: 34735656
doi: 10.1007/s11912-021-01136-5
pii: 10.1007/s11912-021-01136-5
pmc: PMC8568861
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
142Informations de copyright
© 2021. The Author(s).
Références
Br J Haematol. 2015 Aug;170(3):372-83
pubmed: 25907546
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
CMAJ. 2005 Aug 30;173(5):489-95
pubmed: 16129869
World J Exp Med. 2017 Feb 20;7(1):1-10
pubmed: 28261550
Br J Haematol. 2010 Jul;150(2):179-88
pubmed: 20507306
Blood. 2019 Mar 7;133(10):1071-1085
pubmed: 30670445
Semin Hematol. 2018 Oct;55(4):242-247
pubmed: 30502853
Blood. 2005 Aug 15;106(4):1479-87
pubmed: 15827136
Ann Oncol. 2010 Jan;21(1):120-5
pubmed: 19605511
Nat Rev Genet. 2020 Feb;21(2):88-101
pubmed: 31690828
Blood. 2007 Aug 1;110(3):847-50
pubmed: 17412885
Haematologica. 2020 Jan;105(1):38-46
pubmed: 31806690
Wiley Interdiscip Rev RNA. 2021 Jul;12(4):e1643
pubmed: 33565261
Leuk Res. 2011 Dec;35(12):1591-6
pubmed: 21708407
Nat Commun. 2018 Sep 7;9(1):3649
pubmed: 30194306
N Engl J Med. 2011 Oct 13;365(15):1384-95
pubmed: 21995386
Blood. 2012 Mar 15;119(11):2500-9
pubmed: 22289892
Int J Hematol. 2014 Oct;100(4):317-25
pubmed: 25096220
Blood. 2019 Mar 7;133(10):1039-1048
pubmed: 30670444
Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1757-64
pubmed: 20080672
Sci Rep. 2020 Jun 8;10(1):9156
pubmed: 32514107
Ochsner J. 2012 Fall;12(3):216-20
pubmed: 23049458
Haematologica. 2009 Apr;94(4):496-506
pubmed: 19229054
Sci Adv. 2016 Jul 29;2(7):e1600584
pubmed: 27482540
J Exp Med. 2000 Nov 6;192(9):1273-80
pubmed: 11067876
Leukemia. 2017 May;31(5):1069-1078
pubmed: 27833093
Leukemia. 2009 Mar;23(3):510-8
pubmed: 19020538
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
J Intern Med. 2021 Jul;290(1):231-234
pubmed: 33576538
Br J Cancer. 2007 Nov 5;97(9):1189-93
pubmed: 17923865
ScientificWorldJournal. 2001 Aug 08;1:323-36
pubmed: 12806071
Cancer Cell. 2010 Dec 14;18(6):553-67
pubmed: 21130701
Aging Cell. 2017 Oct;16(5):918-933
pubmed: 28703423
Leuk Res. 2012 Jan;36(1):1-5
pubmed: 21920601
Nature. 2011 Sep 11;478(7367):64-9
pubmed: 21909114
Trends Immunol. 2015 Dec;36(12):815-824
pubmed: 26611154
J Gerontol A Biol Sci Med Sci. 2021 Jan 18;76(2):253-259
pubmed: 33295962
Crit Rev Oncol Hematol. 2000 Feb;33(2):143-8
pubmed: 10737376
Mayo Clin Proc. 2018 Jul;93(7):904-916
pubmed: 29804726
Br J Haematol. 2016 Feb;172(4):512-23
pubmed: 26491866
Mitochondrion. 2020 Sep;54:72-84
pubmed: 32738358
Leukemia. 2013 Sep;27(9):1841-51
pubmed: 23797473
Cell Stem Cell. 2016 Nov 3;19(5):613-627
pubmed: 27666011
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
Leuk Lymphoma. 2017 Aug;58(8):1777-1790
pubmed: 27967292
Nat Rev Genet. 2016 Sep 15;17(10):630-41
pubmed: 27629931
N Engl J Med. 2011 Jun 30;364(26):2496-506
pubmed: 21714648
Semin Hematol. 2017 Jan;54(1):1-3
pubmed: 28088981
Mol Cell Proteomics. 2018 Feb;17(2):290-303
pubmed: 29196338
Haematologica. 2020 Jul;105(7):1765-1779
pubmed: 32439724
Pathobiology. 2019;86(1):30-38
pubmed: 29860246
BMC Med. 2018 Nov 27;16(1):220
pubmed: 30477486
Nature. 2015 Jan 15;517(7534):302-10
pubmed: 25592535
Leukemia. 2018 Apr;32(4):1023-1033
pubmed: 29263441
Leukemia. 1999 Mar;13(3):393-9
pubmed: 10086730
Exp Cell Res. 2021 Feb 15;399(2):112474
pubmed: 33434530
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
Cancer Med. 2021 Jun;10(12):3928-3937
pubmed: 33973411
Leukemia. 2014 Feb;28(2):241-7
pubmed: 24220272
Haematologica. 2014 May;99(5):821-9
pubmed: 24463215
J Exp Med. 2013 Nov 18;210(12):2641-59
pubmed: 24218140
Stem Cells. 2021 Aug;39(8):1101-1106
pubmed: 33847429
Blood. 2013 Nov 21;122(22):3616-27; quiz 3699
pubmed: 24030381
J Hematol Oncol. 2020 Apr 6;13(1):31
pubmed: 32252797
Semin Hematol. 2017 Jan;54(1):33-38
pubmed: 28088985
Curr Genomics. 2015 Dec;16(6):435-40
pubmed: 27019618
Leukemia. 2021 Mar;35(3):835-849
pubmed: 32595214
Blood. 2007 Dec 15;110(13):4385-95
pubmed: 17726160
Hemasphere. 2020 Jan 15;4(1):e332
pubmed: 32072148
Blood. 2020 May 28;135(22):1946-1956
pubmed: 32076714
Cancer. 2007 Apr 15;109(8):1536-42
pubmed: 17345612
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Int J Mol Sci. 2019 Mar 13;20(6):
pubmed: 30871268
N Engl J Med. 2014 Dec 25;371(26):2488-98
pubmed: 25426837
N Engl J Med. 2009 May 28;360(22):2289-301
pubmed: 19474426
Nat Commun. 2020 Aug 14;11(1):4075
pubmed: 32796847
Leukemia. 2018 Jun;32(6):1380-1392
pubmed: 29572506
Blood. 2017 Jun 22;129(25):3371-3378
pubmed: 28424163
PLoS One. 2015 May 08;10(5):e0126555
pubmed: 25955609
Genes Chromosomes Cancer. 2010 Mar;49(3):260-9
pubmed: 19998444
Semin Immunol. 2018 Dec;40:61-73
pubmed: 30268598
Stem Cell Res. 2015 Mar;14(2):177-84
pubmed: 25665922
FEBS Lett. 2021 Apr;595(8):976-1002
pubmed: 33314045
Stem Cells Int. 2020 Oct 31;2020:8855038
pubmed: 33178287
Blood. 2015 Jul 2;126(1):9-16
pubmed: 25931582
Blood. 2018 Feb 1;131(5):505-514
pubmed: 29141943