Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin's lymphoma.
Adult
Aged
Aged, 80 and over
Amino Acid Transport System L
/ metabolism
Amino Acid Transport Systems
/ metabolism
Cell Line, Tumor
Cell Proliferation
/ genetics
Female
Gene Expression
/ genetics
Gene Expression Profiling
/ methods
Gene Expression Regulation, Neoplastic
/ genetics
Humans
Large Neutral Amino Acid-Transporter 1
/ genetics
Lymphoma, Non-Hodgkin
/ metabolism
Male
Middle Aged
Prognosis
Transcriptome
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 11 2021
04 11 2021
Historique:
received:
23
01
2021
accepted:
20
09
2021
entrez:
5
11
2021
pubmed:
6
11
2021
medline:
27
1
2022
Statut:
epublish
Résumé
L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients' survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL.
Identifiants
pubmed: 34737339
doi: 10.1038/s41598-021-00811-8
pii: 10.1038/s41598-021-00811-8
pmc: PMC8569019
doi:
Substances chimiques
Amino Acid Transport System L
0
Amino Acid Transport Systems
0
Large Neutral Amino Acid-Transporter 1
0
SLC7A5 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21638Informations de copyright
© 2021. The Author(s).
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