The Skeletal Cellular and Molecular Underpinning of the Murine Hindlimb Unloading Model.
bone loss
disuse osteopenia
hindlimb unloading
mechanotransduction
osteocyte
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
07
2021
accepted:
23
09
2021
entrez:
5
11
2021
pubmed:
6
11
2021
medline:
6
11
2021
Statut:
epublish
Résumé
Bone adaptation to spaceflight results in bone loss at weight bearing sites following the absence of the stimulus represented by ground force. The rodent hindlimb unloading model was designed to mimic the loss of mechanical loading experienced by astronauts in spaceflight to better understand the mechanisms causing this disuse-induced bone loss. The model has also been largely adopted to study disuse osteopenia and therefore to test drugs for its treatment. Loss of trabecular and cortical bone is observed in long bones of hindlimbs in tail-suspended rodents. Over the years, osteocytes have been shown to play a key role in sensing mechanical stress/stimulus
Identifiants
pubmed: 34737712
doi: 10.3389/fphys.2021.749464
pmc: PMC8562483
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
749464Informations de copyright
Copyright © 2021 Garg, Strigini, Peurière, Vico and Iandolo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
FASEB J. 2019 Sep;33(9):10140-10151
pubmed: 31238017
Bone. 1998 May;22(5 Suppl):83S-88S
pubmed: 9600759
Endocrinol Metab (Seoul). 2018 Sep;33(3):318-330
pubmed: 30112869
J Histochem Cytochem. 2003 Mar;51(3):373-83
pubmed: 12588965
Lancet. 2000 May 6;355(9215):1607-11
pubmed: 10821365
Adv Space Biol Med. 2005;10:7-40
pubmed: 16101103
Bone. 2013 Apr;53(2):515-9
pubmed: 23337040
Bone. 2018 Jul;112:1-9
pubmed: 29626544
Endocr Rev. 2012 Oct;33(5):747-83
pubmed: 22723594
Bonekey Osteovision. 2006 Oct;3(10):7-15
pubmed: 17415409
Calcif Tissue Int. 2000 Apr;66(4):298-306
pubmed: 10742449
Cell. 2014 Jul 3;158(1):157-70
pubmed: 24976009
Curr Osteoporos Rep. 2020 Oct;18(5):526-540
pubmed: 32712794
Am J Physiol Regul Integr Comp Physiol. 2015 Jun 15;308(12):R1070-9
pubmed: 25876655
J Bone Miner Res. 1999 Jan;14(1):39-46
pubmed: 9893064
J Bone Miner Res. 2012 Nov;27(11):2359-72
pubmed: 22714552
J Bone Miner Res. 2003 Mar;18(3):561-9
pubmed: 12619942
Calcif Tissue Int. 2018 Jul;103(1):24-34
pubmed: 29332162
Mol Med Rep. 2018 Aug;18(2):2506-2514
pubmed: 29956799
J Biol Chem. 2015 Jul 3;290(27):16744-58
pubmed: 25953900
Osteoporos Int. 2016 Oct;27(10):3091-101
pubmed: 27189604
PLoS One. 2013 Apr 18;8(4):e61372
pubmed: 23637819
Nature. 2012 Jan 11;481(7382):463-8
pubmed: 22237023
J Med Invest. 2001 Aug;48(3-4):147-56
pubmed: 11694954
PLoS One. 2016 Jul 13;11(7):e0158381
pubmed: 27410430
J Bone Miner Res. 2008 Jun;23(6):860-9
pubmed: 18269310
Bone. 2013 Jun;54(2):264-71
pubmed: 23238124
Nat Commun. 2020 Jan 15;11(1):282
pubmed: 31941964
PLoS One. 2014 Mar 24;9(3):e92664
pubmed: 24664102
Calcif Tissue Int. 2020 Aug;107(2):170-179
pubmed: 32451574
Nutrients. 2020 Jul 09;12(7):
pubmed: 32660008
Trends Endocrinol Metab. 2014 Nov;25(11):567-75
pubmed: 25034128
ScientificWorldJournal. 2014 Mar 11;2014:803083
pubmed: 24741361
J Bone Miner Res. 1998 Oct;13(10):1555-68
pubmed: 9783544
Aviakosm Ekolog Med. 1992 Sep-Dec;26(5-6):20-4
pubmed: 1307030
J Bone Miner Res. 2019 Oct;34(10):1964-1975
pubmed: 31173667
PLoS Genet. 2020 May 28;16(5):e1008361
pubmed: 32463812
J Biomech. 1994 Mar;27(3):339-60
pubmed: 8051194
J Bone Miner Metab. 2006;24(6):439-46
pubmed: 17072735
J Biomech. 1992 May;25(5):489-99
pubmed: 1592854
Cell. 2007 Aug 10;130(3):456-69
pubmed: 17693256
Cell Metab. 2016 Jun 14;23(6):1078-1092
pubmed: 27304508
Int J Biochem Cell Biol. 2015 Sep;66:59-68
pubmed: 26159930
Am J Hum Biol. 2011 Sep-Oct;23(5):577-85
pubmed: 21793093
Elife. 2019 Jul 10;8:
pubmed: 31290742
Elife. 2020 Mar 18;9:
pubmed: 32186512
Nat Rev Mol Cell Biol. 2017 Dec;18(12):758-770
pubmed: 28951564
Int J Mol Sci. 2020 Oct 12;21(20):
pubmed: 33053789
Bone. 1996 May;18(5):397-403
pubmed: 8739896
J Biol Chem. 2005 May 20;280(20):19883-7
pubmed: 15778503
Nature. 2011 Jun 08;474(7350):179-83
pubmed: 21654799
J Clin Invest. 2006 May;116(5):1202-9
pubmed: 16670761
Biotech Histochem. 2005 May-Aug;80(3-4):111-5
pubmed: 16298895
Hum Mol Genet. 2001 Mar 1;10(5):537-43
pubmed: 11181578
Biotechnol Bioeng. 2020 Jan;117(1):251-271
pubmed: 31531968
FASEB J. 2010 Aug;24(8):2859-68
pubmed: 20371630
J Bone Miner Res. 2011 Feb;26(2):277-85
pubmed: 20715178
ILAR J. 2006;47(4):364-9
pubmed: 16963816
Bone. 2010 Nov;47(5):872-81
pubmed: 20713195
Bone Res. 2020 Jun 8;8:23
pubmed: 32550039
FEBS Lett. 2014 Apr 17;588(8):1315-21
pubmed: 24486014
J Bone Miner Res. 2015 Feb;30(2):357-68
pubmed: 25112732
Sci Rep. 2020 Apr 16;10(1):6484
pubmed: 32300161
Elife. 2020 Aug 11;9:
pubmed: 32780016
Eur J Pharmacol. 2015 Jul 15;759:287-94
pubmed: 25814262
Organogenesis. 2008 Apr;4(2):68-75
pubmed: 19279717
FASEB J. 2020 Aug;34(8):10096-10106
pubmed: 32539174
J Exp Med. 2001 Feb 5;193(3):399-404
pubmed: 11157060
Am J Physiol Endocrinol Metab. 2012 Dec 1;303(11):E1354-62
pubmed: 23047986
Bone. 2017 Dec;105:26-34
pubmed: 28782619
Bone. 2013 Nov;57(1):76-83
pubmed: 23891909
Aviat Space Environ Med. 1987 Oct;58(10):996-1000
pubmed: 3675473
Metabolism. 2004 Nov;53(11):1417-23
pubmed: 15536595
Metabolites. 2016 Aug 03;6(3):
pubmed: 27527232
Sci Signal. 2017 Nov 21;10(506):
pubmed: 29162742
PLoS One. 2015 Nov 10;10(11):e0140775
pubmed: 26554834
Front Endocrinol (Lausanne). 2018 Jun 04;9:289
pubmed: 29915560
Front Physiol. 2017 Oct 13;8:799
pubmed: 29081752
Stem Cells. 2015 Oct;33(10):3065-76
pubmed: 26140478
PLoS One. 2014 Mar 21;9(3):e92427
pubmed: 24658423
Mol Cell Biol. 2010 Jan;30(1):206-19
pubmed: 19841066
J Appl Physiol (1985). 2010 Aug;109(2):350-7
pubmed: 20522735
Science. 2010 Oct 1;330(6000):55-60
pubmed: 20813920
Bone. 2010 Mar;46(3):577-83
pubmed: 19925896
Biomed Sci Instrum. 1990;26:87-94
pubmed: 2334784
Bone. 2020 Jun;135:115317
pubmed: 32169602
J Bone Miner Res. 2011 Feb;26(2):229-38
pubmed: 21254230
J Biol Chem. 2015 Jul 31;290(31):18934-42
pubmed: 26085098
Anat Rec. 1987 Sep;219(1):1-9
pubmed: 3688455
Calcif Tissue Int. 2004 May;74(5):469-75
pubmed: 14961209
Endocr Connect. 2019 Nov;8(11):1455-1467
pubmed: 31590144
PLoS One. 2015 Sep 22;10(9):e0138189
pubmed: 26393791
Bone. 2020 Jan;130:115108
pubmed: 31704341
Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H628-38
pubmed: 26747504
J Intern Med. 2015 Jun;277(6):630-49
pubmed: 25845559
Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12157-62
pubmed: 26374841
Curr Mol Biol Rep. 2017 Jun;3(2):122-132
pubmed: 29057206
J Biol Chem. 2008 Feb 29;283(9):5866-75
pubmed: 18089564
Sci Rep. 2019 Jun 27;9(1):9336
pubmed: 31249331
Cell Rep. 2020 Apr 14;31(2):107501
pubmed: 32294435
Calcif Tissue Int. 2014 Mar;94(3):327-37
pubmed: 24240478
PLoS One. 2017 Aug 14;12(8):e0182970
pubmed: 28806419
Sci Rep. 2017 Jun 6;7(1):2811
pubmed: 28588307
Bone. 2009 Apr;44(4):612-8
pubmed: 19168165
Elife. 2021 Mar 29;10:
pubmed: 33779549
Inflamm Regen. 2020 Feb 7;40:2
pubmed: 32047573
Mol Metab. 2012 Nov 08;2(1):5-9
pubmed: 24024125
J Bone Miner Res. 2013 Apr;28(4):865-74
pubmed: 23109229
Cell Metab. 2020 Oct 6;32(4):575-590.e7
pubmed: 32916104
J Bone Miner Res. 2016 Jul;31(7):1356-65
pubmed: 26852281
J Osteoporos. 2011;2011:293808
pubmed: 21876833
Endocrinology. 2016 Feb;157(2):508-21
pubmed: 26696121
Exp Cell Res. 2012 Oct 15;318(17):2237-44
pubmed: 22771842
J Appl Physiol (1985). 2005 Feb;98(2):690-6
pubmed: 15465888
J Bone Miner Res. 2010 Dec;25(12):2657-68
pubmed: 20578217
Colloids Surf B Biointerfaces. 2019 Oct 1;182:110332
pubmed: 31325776
Mol Metab. 2018 Jan;7:161-170
pubmed: 29122558
J Appl Physiol (1985). 2002 Apr;92(4):1367-77
pubmed: 11895999
J Bone Miner Res. 2012 Mar;27(3):499-505
pubmed: 22354849
J Musculoskelet Neuronal Interact. 2016 Sep 07;16(3):221-36
pubmed: 27609037
J Biol Chem. 2006 Oct 20;281(42):31720-8
pubmed: 16908522
J Appl Physiol (1985). 2016 May 15;120(10):1196-206
pubmed: 26869711
Nature. 2017 Mar 16;543(7645):385-390
pubmed: 28273060
J Appl Physiol (1985). 2018 Jun 1;124(6):1616-1628
pubmed: 29470148
J Bone Miner Metab. 2011 Jan;29(1):111-22
pubmed: 20589403
Aviat Space Environ Med. 1994 Dec;65(12):1091-6
pubmed: 7872909
J Exp Biol. 2000 Sep;203(Pt 18):2737-45
pubmed: 10952874
Bone. 2018 May;110:29-37
pubmed: 29414598
Sci Rep. 2017 Apr 12;7:46325
pubmed: 28402337
Front Physiol. 2019 Sep 13;10:1147
pubmed: 31572207
Nat Cell Biol. 2001 Jul;3(7):683-6
pubmed: 11433302
Am J Transl Res. 2019 Sep 15;11(9):5847-5857
pubmed: 31632553
Eur Cell Mater. 2012 Sep 24;24:278-91
pubmed: 23007912
J Cell Physiol. 2013 Nov;228(11):2210-21
pubmed: 23606520
J Bone Miner Res. 2009 Oct;24(10):1651-61
pubmed: 19419300
Comp Med. 2013 Oct;63(5):386-91
pubmed: 24210014
Calcif Tissue Int. 2015 Jan;96(1):65-72
pubmed: 25398598
Mol Cell Biol. 2002 Feb;22(4):1172-83
pubmed: 11809808
Drugs Aging. 2020 Nov;37(11):845-855
pubmed: 32909197
J Bone Miner Res. 2018 Jun;33(6):1141-1153
pubmed: 29444358
J Biol Chem. 2003 Oct 31;278(44):43146-56
pubmed: 12939279