New Regions With Molecular Alterations in a Rare Case of Insulinomatosis: Case Report With Literature Review.
CEBPA
FOXL2
IRS2
copy number variation
insulinomatosis
neuroendocrine tumors
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
08
2021
accepted:
28
09
2021
entrez:
5
11
2021
pubmed:
6
11
2021
medline:
19
2
2022
Statut:
epublish
Résumé
Insulinomatosis is characterized by monohormonality of multiple macro-tumors and micro-tumors that arise synchronously and metachronously in all regions of the pancreas, and often recurring hypoglycemia. One of the main characteristics of insulinomatosis is the presence of insulin-expressing monohormonal endocrine cell clusters that are exclusively composed of proliferating insulin-positive cells, are less than 1 mm in size, and show solid islet-like structure. It is presumed that insulinomatosis affects the entire population of β-cells. With regards to molecular genetics, this phenomenon is not related to mutation in
Identifiants
pubmed: 34737724
doi: 10.3389/fendo.2021.760154
pmc: PMC8563021
doi:
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
760154Informations de copyright
Copyright © 2021 Anoshkin, Vasilyev, Karandasheva, Shugay, Kudryavtseva, Egorov, Gurevich, Mironova, Serikov, Kutsev and Strelnikov.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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