Early corneal and optic nerve changes in a paediatric population affected by obstructive sleep apnea syndrome.

Adult Child Humans Nerve Fibers Optic Nerve Prospective Studies Retinal Ganglion Cells Sleep Apnea, Obstructive / complications Tomography, Optical Coherence / methods
Keratoconus OSAS Obstructive sleep apnoea syndrome Paediatric ophthalmology RNFL Sleep respiratory disorders

Journal

International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 12 05 2021
accepted: 21 10 2021
pubmed: 6 11 2021
medline: 13 4 2022
entrez: 5 11 2021
Statut: ppublish

Résumé

The relation between OSAS and eye diseases is well known in adults, while very few and contradictory data can be found regarding paediatric ages. The aim of this study is to explore the early corneal, macular and optic nerve changes in paediatric patients with OSAS. Prospective study that enrolled children aged ≥ 4 years referred to the Paediatric Pneumology Clinic in Verona for suspected obstructive sleep apnoea syndrome (OSAS) and investigated with the overnight respiratory polygraphy. Patients with apnoea-hypopnea index (AHI) > 1 were classified as OSAS, while those with AHI < 1 were classified non-OSAS. All patients underwent comprehensive eye examination including slit lamp, refraction, intraocular pression (Goldman applanation tonometry), corneal tomography (corneal astigmatism, corneal keratometry at the apex, surface asymmetry index, central corneal thickness and thinnest corneal thickness) and optical coherence tomography (central macular thickness, macular volume and retinal nerve fibre layer). Seventy-two children were enrolled in the study. The overall prevalence of OSAS was 48.6%. Statistically significant differences were found between OSAS and non-OSAS group for corneal asymmetry (0.9 ± 0.5 and 0.6 ± 0.3, respectively; p = 0.02), thinnest corneal thickness (551.8 ± 33.9 and 563.7 ± 32.5; p = 0.04), average retinal nerve fibre layer (102.8 ± 10.5 µm and 98.1 ± 12.3 µm; p = 0.012) and in nasal quadrant (76.2 ± 15.4 µm and 66.5 ± 12.6 µm; p = 0.0002). A comprehensive eye examination with corneal and optic nerve imaging showed early corneal and optic nerve changes in children newly diagnosed with OSAS. These could be prelude of the known ocular manifestations associated with OSAS in adult patients.

Identifiants

DOI: 10.1007/s10792-021-02115-2 PMID: 34738205
pubmed: 34738205
doi: 10.1007/s10792-021-02115-2
pii: 10.1007/s10792-021-02115-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1281-1287

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature B.V.

Références

Kaditis AG, Alonso Alvarez ML, Boudewyns A, Alexopoulos EI, Ersu R, Joosten K et al (2016) Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management. Eur Respir J 47:69–94
doi: 10.1183/13993003.00385-2015
Cohen-Gogo S, Do NT, Levy D, Metreau J, Mornand P, Parisot P et al (2009) Sleep-disordered breathing in children. Arch Pediatr 16:123–131
doi: 10.1016/j.arcped.2008.11.016
Katz ES, D’Ambrosio CM (2008) Pathophysiology of pediatric obstructive sleep apnea. Proc Am Thorac Soc 5:253–262
doi: 10.1513/pats.200707-111MG
Shott SR (2011) Evaluation and management of pediatric obstructive sleep apnea beyond tonsillectomy and adenoidectomy. Curr Opin Otolaryngol Head Neck Surg 19:449–454
doi: 10.1097/MOO.0b013e32834c1728
Nandalike K, Shifteh K, Sin S, Strauss T, Stakofsky A, Gonik N et al (2013) Adenotonsillectomy in obese children with obstructive sleep apnea syndrome: magnetic resonance imaging findings and considerations. Sleep 36:841–847
doi: 10.5665/sleep.2708
Tagetti A, Bonafini S, Zaffanello M, Benetti MV, Vedove FD, Gasperi E et al (2017) Sleep disordered breathing is associated with blood pressure and carotid arterial stiffness in a sample of obese children. J Hypertens 35:125–131
doi: 10.1097/HJH.0000000000001123
Somers VK, Mark AL, Zavala DC, Abboud FM (1989) Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67:2101–2106
doi: 10.1152/jappl.1989.67.5.2101
McNab AA (2007) The eye and sleep apnea. Sleep Med Rev 11:269–276
doi: 10.1016/j.smrv.2007.03.006
Pedrotti E, Demasi CL, Bruni E, Bosello F, Di Sarro PP, Passilongo M et al (2017) Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLEEPY cohort study. BMJ Open 7:e016142
doi: 10.1136/bmjopen-2017-016142
Cinici E, Tatar A (2015) Thickness alterations of retinal nerve fiber layer in children with sleep-disordered breathing due to adenotonsillar hypertrophy. Int J Pediatr Otorhinolaryngol 79:1218–1223
doi: 10.1016/j.ijporl.2015.05.017
Simsek A, Bayraktar C, Dogan S, Uckrdes F, Reyhan AH, Sarikaya Y et al (2016) Retinal nerve fiber layer thickness alteration in apneic children. Optom Vis Sci 93:63–69
doi: 10.1097/OPX.0000000000000745
BMI Percentile Calculator for Child and Teen English Version. Available from https://www.cdc.gov/healthyweight/bmi/calculator.html . (accessed 17 Feb 2019).
Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK et al (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. deliberations of the sleep apnea definitions task force of the american academy of sleep medicine. J Clin Sleep Med 8:597–619
doi: 10.5664/jcsm.2172
Turk A, Ceylan OM, Arici C, Keskin S, Erdurman C, Durukan AH et al (2012) Evaluation of the nerve fiber layer and macula in the eyes of healthy children using spectral-domain optical coherence tomography. Am J Ophthalmol 153:552–559
doi: 10.1016/j.ajo.2011.08.026
Kirk V, Baughn J, D’Andrea L, Friedman N, Galion A, Garetz S et al (2017) American academy of sleep medicine position paper for the use of a home sleep apnea test for the diagnosis of OSA in children. J Clin Sleep Med 13(10):1199–1203
doi: 10.5664/jcsm.6772
Corral J, Sanchez-Quiroga MA, Carmona-Bernal C, Sánchez-Armengol Á, de la Torre AS, Durán-Cantolla J et al (2017) Conventional polysomnography is not necessary for the management of most patients with suspected obstructive sleep apnea non inferiority, randomized controlled trial. Am J Respir Crit Care Med 196(9):1181–1190
doi: 10.1164/rccm.201612-2497OC
Reddy SP, Bansal R, Vaddavalli PK (2013) Corneal topography and corneal thickness in children. J Pediatr Ophthalmol Strabismus 50:304–310
doi: 10.3928/01913913-20130806-02
Burns DM, Johnston FM, Frazer DG, Patterson C, Jackson AJ (2004) Keratoconus: an analysis of corneal asymmetry. Br J Ophthalmol 88:1252–1255. https://doi.org/10.1136/bjo.2003.033670
doi: 10.1136/bjo.2003.033670 pubmed: 15377544 pmcid: 1772341
Lee S, McArdle N, Sanfilippo PG, Yazar S, Eastwood PR, Hewitt AW, Li Q, Mackey DA (2019) Associations between optic disc measures and obstructive sleep apnea in young adults. Ophthalmology 126(10):1372–1384. https://doi.org/10.1016/j.ophtha.2019.04.041
doi: 10.1016/j.ophtha.2019.04.041 pubmed: 31196726
Huseyinoglu N, Ekinci M, Ozben S, Buyukuysal C, Kale MY, Sanivar HS (2014) Optic disc and retinal nerve fiber layer parameters as indicators of neurodegenerative brain changes in patients with obstructive sleep apnea syndrome. Sleep Breath 18(1):95–102. https://doi.org/10.1007/s11325-013-0854-z
doi: 10.1007/s11325-013-0854-z pubmed: 23636560
Dhillon S, Shapiro CM, Flanagan J (2007) Sleep-disordered breathing and effects on ocular health. Can J Ophthalmol 42:238–243
doi: 10.3129/can.j.ophthalmol.i07-029
Stein JD, Kim DS, Mundy KM, Talwar N, Nan B, Chervin RD, Musch DC (2011) The association between glaucomatous and other causes of optic neuropathy and sleep apnea. Am J Ophthalmol 152:989–998
doi: 10.1016/j.ajo.2011.04.030
Jaki Mekjavic P, Lenassi E, Eiken O, Mekjavic JB (2016) Effect of acute hypercapnia during 10-day hypoxic bed rest on posterior eye structures. J Appl Physiol 120:1241–1248
doi: 10.1152/japplphysiol.00930.2015
Wang JS, Xie HT, Jia Y, Zhang MC (2016) Retinal nerve fiber layer thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis. Int J Ophthalmol 9:1651–1656
pubmed: 27990371 pmcid: 5145096
Frisen L (1982) Swelling of the optic nerve head: a staging scheme. J Neurol Neurosurg Psychiatry 45:13–18
doi: 10.1136/jnnp.45.1.13

Auteurs

Erika Bonacci (E)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.

Adriano Fasolo (A)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.

Marco Zaffanello (M)

Pediatric Division, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Piazzale Stefani 1, 37126, Verona, VR, Italy.

Tommaso Merz (T)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.

Giacomo Brocoli (G)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.
Eye Clinic, Department of Sense Organs, Sapienza University of Rome, Pz.Le A Moro 5, 00185, Rome, RM, Italy.

Angelo Pietrobelli (A)

Pediatric Division, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Piazzale Stefani 1, 37126, Verona, VR, Italy.

Maria Clemente (M)

Pediatric Division, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Piazzale Stefani 1, 37126, Verona, VR, Italy.

Alessandra De Gregorio (A)

Ophthalmic Unit, San Bassiano Hospital, Via dei Lotti, 40, 36061, Bassano del Grappa, VI, Italy.

Rosa Longo (R)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.

Francesca Bosello (F)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy. francesca.bosello87@gmail.com.
ORCID: 0000-0003-0082-2197

Giorgio Marchini (G)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.

Emilio Pedrotti (E)

Eye Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Pz.Le LA Scuro 10, 37100, Verona, VR, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs crâniens › Nerf optique › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules ganglionnaires rétiniennes › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Early corneal and optic nerve changes in a...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › Early corneal and optic nerve changes in a...