NADPH-to-NADH conversion by mitochondrial transhydrogenase is indispensable for sustaining anaerobic metabolism in Euglena gracilis.
Euglena gracilis
anaerobic respiration
malic enzyme
transhydrogenase
wax ester fermentation
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
29
10
2021
received:
14
10
2021
accepted:
29
10
2021
pubmed:
6
11
2021
medline:
1
1
2022
entrez:
5
11
2021
Statut:
ppublish
Résumé
Euglena gracilis produces ATP in the anaerobic mitochondria with concomitant wax ester formation, and NADH is essential for ATP formation and fatty acid synthesis in the mitochondria. This study demonstrated that mitochondrial cofactor conversion by nicotinamide nucleotide transhydrogenase (NNT), converting NADPH/NAD
Identifiants
pubmed: 34738635
doi: 10.1002/1873-3468.14221
doi:
Substances chimiques
NAD
0U46U6E8UK
NADP
53-59-8
Malate Dehydrogenase
EC 1.1.1.37
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
EC 1.1.1.40
NADP Transhydrogenases
EC 1.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2922-2930Informations de copyright
© 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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