Inhibition of hydroxylated polychlorinated biphenyls (OH-PCBs) on sulfotransferases (SULTs).

Chromatography, Liquid Humans Hydroxylation Polychlorinated Biphenyls / toxicity Sulfates Sulfotransferases / metabolism
Human sulfotransferases (SULTs) Hydroxylated polychlorinated biphenyls (OH-PCBs) In vitro-in vivo extrapolation (IVIVE) Inhibition

Journal

Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476

Informations de publication

Date de publication:
15 Dec 2021
Historique:
received: 01 04 2021
revised: 17 09 2021
accepted: 19 09 2021
entrez: 6 11 2021
pubmed: 7 11 2021
medline: 10 11 2021
Statut: ppublish

Résumé

Polychlorinated biphenyls (PCBs) have been demonstrated as a kind of the persistent organic pollutants (POPs) that could exert complicated influences towards metabolism in human bodies. Since hydroxylated polychlorinated biphenyls (OH-PCBs) are important metabolites of PCBs, our study focuses on investigating the potential inhibitory capability of OH-PCBs on four human sulfotransferase (SULT) isoforms. P-nitrophenol (PNP) was utilized as nonselective probe substrate for this study, and recombinant SULT isoforms were utilized as the enzyme resources. Ultra-performance liquid chromatography (UPLC)-UV detecting system was used to analyze PNP and its metabolite PNP-sulfate. As result, 100 μM of most tested OH-PCBs significantly inhibited the activity of four SULT isoforms. Concentration-dependent inhibition of OH-PCBs towards SULTs was found, and half inhibition concentration values (IC

Identifiants

DOI: 10.1016/j.envpol.2021.118214 PMID: 34740292
pubmed: 34740292
pii: S0269-7491(21)01796-6
doi: 10.1016/j.envpol.2021.118214
pii:
doi:

Substances chimiques

Sulfates 0
Polychlorinated Biphenyls DFC2HB4I0K
Sulfotransferases EC 2.8.2.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

118214

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Ruo-Yong Jia (RY)

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.

Zhi-Peng Zhang (ZP)

Department of Surgery, Peking University Third Hospital, Beijing, China.

Guo-Qiang Qin (GQ)

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.

Wei Zhang (W)

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.

Kun Yang (K)

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.

Yong-Zhe Liu (YZ)

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.

Changtao Jiang (C)

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, China.

Zhong-Ze Fang (ZZ)

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; National Demonstration Center for Experimental Preventive Medicine Education, Tianjin Medical University, Tianjin, 300070, China; Tianjin Center for International Collaborative Research in Environment, Nutrition and Public Health, Tianjin, China. Electronic address: fangzhongze@tmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Inhibition of hydroxylated polychlorinated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibition of hydroxylated polychlorinated...
questionsmedicales.fr › Métabolisme › Hydroxylation › Inhibition of hydroxylated polychlorinated...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Polychlorobiphényles › Inhibition of hydroxylated polychlorinated...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfates › Inhibition of hydroxylated polychlorinated...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Sulfur group transferases › Sulfotransferases › Inhibition of hydroxylated polychlorinated...