Who are the placebo responders? A cross-sectional cohort study for psychological determinants.
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
received:
01
04
2021
accepted:
02
09
2021
pubmed:
7
11
2021
medline:
18
5
2022
entrez:
6
11
2021
Statut:
ppublish
Résumé
A number of studies have demonstrated substantial individual differences in placebo effects. We aimed to identify individual psychological factors that potentially predicted the magnitude of placebo hypoalgesia and individual responsiveness. The Research Domain Criteria framework and a classical conditioning with suggestions paradigm were adopted as experimental models to study placebo phenotypes in a cohort of 397 chronic pain participants with a primary diagnosis of temporomandibular disorder (TMD) and 397 healthy control (HC) participants. The magnitude of placebo hypoalgesia was operationalized as the average difference in pain ratings between the placebo and control conditions. The individual placebo responsiveness was identified as the status of placebo responders and nonresponders based on a permutation test. We observed significant placebo effects in both TMD and HC participants. A greater level of emotional distress was a significant predictor of smaller magnitude (slope b = -0.07) and slower extinction rate (slope b = 0.51) of placebo effects in both TMD and HC participants. Greater reward seeking was linked to greater postconditioning expectations (ie, reinforced expectations) in TMD (slope b = 0.16), but there was no such a prediction in HC participants. These findings highlight that negative valence systems might play a role in impairing placebo effects, with a larger impact in chronic pain participants than in healthy participants, suggesting that individuals reporting emotional distress and maladaptive cognitive appraisals of pain may benefit less from placebo effects.
Identifiants
pubmed: 34740998
doi: 10.1097/j.pain.0000000000002478
pii: 00006396-202206000-00013
pmc: PMC8907332
mid: NIHMS1739333
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1078-1090Subventions
Organisme : NCCIH NIH HHS
ID : R01 AT010333
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT011347
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025946
Pays : United States
Organisme : NIAAA NIH HHS
ID : R13 AA028424
Pays : United States
Informations de copyright
Copyright © 2021 International Association for the Study of Pain.
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