Risk Factors of Anencephaly: A Case-Control Study in Dessie Town, North East Ethiopia.
anencephaly
khat chewing
neural tube defects
ultrasound
Journal
Pediatric health, medicine and therapeutics
ISSN: 1179-9927
Titre abrégé: Pediatric Health Med Ther
Pays: New Zealand
ID NLM: 101655856
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
08
2021
accepted:
16
10
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Anencephaly is a form of neural tube defect, which develops when the cranial neuropore is unable to close. It is one of the fatal anomalies of the neural tube. Although most of the causes of anencephaly are unknown, multiple risk factors are associated with this defect. Therefore, this study aimed to investigate the incidence and associated risk factors of anencephaly in Dessie town, in the north eastern region of Ethiopia. An institution-based unmatched case-control study was conducted. Sociodemographic characteristics of pregnant women were collected with a structured questionnaire and clinical data were recorded during an ultrasound examination. Data were entered into Epi Info 7 and analyzed by SPSS version 20. Binary logistic regression was applied to detect the associations between risk factors and the occurrence of anencephaly. The incidence of anencephaly was 3.3/1000 pregnancies. The multivariate logistic regression model indicated that maternal age between 26 and 30 years and khat chewing during pregnancy were significantly associated with anencephaly (OR 0.13, 95% CI 0.02-0.97, It is suggested that exposure to risk factors such as khat chewing during pregnancy may predispose to the development of anencephaly.
Identifiants
pubmed: 34744469
doi: 10.2147/PHMT.S332561
pii: 332561
pmc: PMC8565987
doi:
Types de publication
Journal Article
Langues
eng
Pagination
499-506Informations de copyright
© 2021 Abebe et al.
Déclaration de conflit d'intérêts
All authors declare that they have no conflicts of interest.
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