Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.
ECoG
EEG
biomarkers
biotypes
depression
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
07
2021
accepted:
02
09
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Major depressive disorder is a common and disabling disorder with high rates of treatment resistance. Evidence suggests it is characterized by distributed network dysfunction that may be variable across patients, challenging the identification of quantitative biological substrates. We carried out this study to determine whether application of a novel computational approach to a large sample of high spatiotemporal resolution direct neural recordings in humans could unlock the functional organization and coordinated activity patterns of depression networks. This group level analysis of depression networks from heterogenous intracranial recordings was possible due to application of a correlational model-based method for inferring whole-brain neural activity. We then applied a network framework to discover brain dynamics across this model that could classify depression. We found a highly distributed pattern of neural activity and connectivity across cortical and subcortical structures that was present in the majority of depressed subjects. Furthermore, we found that this depression signature consisted of two subnetworks across individuals. The first was characterized by left temporal lobe hypoconnectivity and pathological beta activity. The second was characterized by a hypoactive, but hyperconnected left frontal cortex. These findings have applications toward personalization of therapy.
Identifiants
pubmed: 34744662
doi: 10.3389/fnhum.2021.746499
pmc: PMC8566975
doi:
Types de publication
Journal Article
Langues
eng
Pagination
746499Informations de copyright
Copyright © 2021 Scangos, Khambhati, Daly, Owen, Manning, Ambrose, Austin, Dawes, Krystal and Chang.
Déclaration de conflit d'intérêts
AKr consults for Eisai, Evecxia, Ferring, Galderma, Harmony Biosciences, Idorsia, Jazz, Janssen, Merck, Neurocrine, Pernix, Sage, and Takeda. EC has patents related to brain stimulation for neuropsychiatric conditions, brain mapping, and speech neuroprosthesis and also given talks related to epilepsy treatment for Neuropace and Cyberonics/Livanova. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
PLoS One. 2011;6(9):e25423
pubmed: 21980454
Epilepsy Behav. 2005 Aug;7(1):37-50
pubmed: 15975853
Ann N Y Acad Sci. 2010 Mar;1191:133-55
pubmed: 20392279
Depress Anxiety. 2001;13(1):32-7
pubmed: 11233458
BMJ. 2019 Apr 9;365:l1476
pubmed: 30967483
Front Syst Neurosci. 2010 Sep 20;4:
pubmed: 20941370
J Abnorm Psychol. 2000 Nov;109(4):797-802
pubmed: 11196007
Eur Neuropsychopharmacol. 2018 Jan;28(1):109-117
pubmed: 29153927
Biol Psychiatry. 2009 Feb 15;65(4):267-75
pubmed: 18842257
Epilepsy Behav. 2003 Dec;4 Suppl 4:S26-30
pubmed: 14654425
Arch Gen Psychiatry. 2005 Apr;62(4):387-96
pubmed: 15809406
J Abnorm Psychol. 1991 Nov;100(4):535-45
pubmed: 1757667
J Affect Disord. 2010 Apr;122(1-2):76-85
pubmed: 19589603
Physiol Behav. 2016 Nov 1;166:22-31
pubmed: 27195458
J Neurosci. 2012 Jun 27;32(26):8871-8
pubmed: 22745488
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep;74(3 Pt 2):036104
pubmed: 17025705
Nat Rev Neurol. 2011 Jan;7(1):31-40
pubmed: 21135885
Psychiatry Clin Neurosci. 2009 Dec;63(6):754-61
pubmed: 20021629
Biol Psychiatry. 2010 Jan 15;67(2):161-7
pubmed: 19811772
Brain. 2016 Dec;139(Pt 12):3296-3309
pubmed: 27742666
J Stat Mech. 2005 Feb 1;2005(P02001):nihpa35573
pubmed: 18159217
Hum Brain Mapp. 2017 May;38(5):2482-2494
pubmed: 28176413
Psychol Med. 2015 Mar;45(4):693-704
pubmed: 25010396
Psychophysiology. 1993 Jan;30(1):82-9
pubmed: 8416065
Front Neuroinform. 2017 Oct 31;11:62
pubmed: 29163118
JAMA. 1999 Nov 10;282(18):1737-44
pubmed: 10568646
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:1419-22
pubmed: 22254584
Cereb Cortex. 2018 Apr 1;28(4):1383-1395
pubmed: 29300840
J Neurosci. 2013 Mar 13;33(11):5000-5
pubmed: 23486970
Am J Obstet Gynecol. 2000 Sep;183(3):759-69
pubmed: 10992206
PLoS One. 2014 May 07;9(5):e96505
pubmed: 24806295
Epilepsia. 2015 Nov;56(11):1660-8
pubmed: 26391203
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11020-5
pubmed: 20534464
Proc IEEE Inst Electr Electron Eng. 2018 May;106(5):846-867
pubmed: 30559531
Biol Psychiatry. 2003 Aug 1;54(3):388-98
pubmed: 12893113
Nat Commun. 2018 Jan 24;9(1):346
pubmed: 29367627
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jan;2(1):66-75
pubmed: 28944305
Biol Psychiatry. 2011 Feb 15;69(4):301-8
pubmed: 21145043
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Sep;3(9):731-741
pubmed: 29571586
Mol Neurobiol. 2014 Dec;50(3):1111-23
pubmed: 24705817
Neuron. 2013 Feb 6;77(3):586-95
pubmed: 23395382
J ECT. 2019 Jun;35(2):95-102
pubmed: 30531398
Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6798-807
pubmed: 26598686
Epilepsia. 2006;47 Suppl 2:28-33
pubmed: 17105456
Ther Adv Neurol Disord. 2009 Sep;2(5):337-44
pubmed: 21180624
J Neurosci Methods. 2010 Aug 15;191(1):101-9
pubmed: 20595035
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
J Psychiatr Res. 2012 Nov;46(11):1483-91
pubmed: 22939462
J Abnorm Psychol. 1990 Feb;99(1):22-31
pubmed: 2307762
Nat Neurosci. 2017 Feb 23;20(3):353-364
pubmed: 28230844
Science. 2002 Aug 30;297(5586):1551-5
pubmed: 12202830
Neurosci Lett. 2012 Apr 11;514(1):86-90
pubmed: 22395089
Front Syst Neurosci. 2010 Oct 08;4:147
pubmed: 21031030
Am J Psychiatry. 2001 Jun;158(6):899-905
pubmed: 11384897
Biol Psychiatry. 2007 Sep 1;62(5):429-37
pubmed: 17210143
IEEE Trans Med Imaging. 2009 Apr;28(4):508-22
pubmed: 19273000
J Affect Disord. 2012 Jun;139(1):56-65
pubmed: 22425432
Cereb Cortex. 2016 Jul;26(7):3285-96
pubmed: 27102654
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
JAMA Psychiatry. 2018 Feb 1;75(2):201-209
pubmed: 29197929
PLoS One. 2012;7(8):e41282
pubmed: 22916105
Mol Psychiatry. 2018 Apr;23(4):843-849
pubmed: 28397839
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Electroencephalogr Clin Neurophysiol. 1994 Dec;91(6):442-55
pubmed: 7529683
Cell. 2018 Nov 29;175(6):1688-1700.e14
pubmed: 30415834
Basic Clin Neurosci. 2018 Jul-Aug;9(4):227-240
pubmed: 30519381
Cereb Cortex. 2020 Sep 3;30(10):5333-5345
pubmed: 32495832
Biol Psychiatry. 2012 Apr 1;71(7):611-7
pubmed: 22177602
Front Hum Neurosci. 2019 Jan 09;12:521
pubmed: 30687041
Neuroreport. 1997 Mar 3;8(4):1057-61
pubmed: 9141092
Biol Psychiatry. 2014 Oct 1;76(7):567-74
pubmed: 24690111
Hum Brain Mapp. 2013 Sep;34(9):2154-77
pubmed: 22438275
Epilepsia. 2012 Jun;53(6):1095-103
pubmed: 22578079
Nat Neurosci. 2015 Nov;18(11):1664-71
pubmed: 26457551
Neuropsychopharmacology. 2009 Mar;34(4):932-43
pubmed: 18536699
Biol Psychol. 2010 Oct;85(2):350-4
pubmed: 20708650
Neuroimage. 2011 May 1;56(1):235-45
pubmed: 21238595
Science. 2010 Jan 15;327(5963):348-51
pubmed: 20075256
Nat Biomed Eng. 2019 Nov;3(11):902-916
pubmed: 31133741
Adv Neurol. 2006;97:367-74
pubmed: 16383147
Am J Psychiatry. 2019 Jan 1;176(1):82
pubmed: 30848947
Psychophysiology. 1992 Sep;29(5):576-92
pubmed: 1410187
Epilepsia. 2000;41 Suppl 2:S31-41
pubmed: 10885738
Ann Fam Med. 2010 Jul-Aug;8(4):348-53
pubmed: 20644190
Epilepsia. 2009 May;50(5):1051-8
pubmed: 19183219
J Neurosci Methods. 2012 Jan 30;203(2):386-97
pubmed: 22001222
Nat Biotechnol. 2018 Nov;36(10):954-961
pubmed: 30199076
Nat Neurosci. 2015 May;18(5):744-51
pubmed: 25849989
Chaos. 2013 Mar;23(1):013142
pubmed: 23556979
Biol Psychiatry. 2002 Feb 15;51(4):342-4
pubmed: 11958786
Trends Cogn Sci. 2013 Dec;17(12):683-96
pubmed: 24231140
Mol Psychiatry. 2014 Nov;19(11):1186-92
pubmed: 24514569
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Mar;83(3 Pt 2):036103
pubmed: 21517554
Biol Psychiatry. 2011 Aug 15;70(4):334-42
pubmed: 21791259
Epilepsy Curr. 2005 Sep-Oct;5(5):176-81
pubmed: 16175217
J Affect Disord. 2013 Apr 25;146(3):401-6
pubmed: 23116810
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12893-7
pubmed: 21737744
Brain. 2012 May;135(Pt 5):1498-507
pubmed: 22418737
Neurobiol Dis. 2012 Dec;48(3):329-38
pubmed: 22820143
Neuroimage. 2017 Jan 15;145(Pt B):137-165
pubmed: 27012503
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573
Neuroimage. 2013 Oct 15;80:360-78
pubmed: 23707587
J Neuropsychiatry Clin Neurosci. 2020 Spring;32(2):185-190
pubmed: 31394989
Sci Rep. 2018 Feb 6;8(1):2507
pubmed: 29410486