Plasmalogens and Chronic Inflammatory Diseases.

aging degenerative disorders inflammation metabolic disorders oxidative stress plasmalogen plasmalogen replacement therapy polyunsaturated fatty acids

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2021
Historique:
received: 25 06 2021
accepted: 14 09 2021
entrez: 8 11 2021
pubmed: 9 11 2021
medline: 9 11 2021
Statut: epublish

Résumé

It is becoming widely acknowledged that lipids play key roles in cellular function, regulating a variety of biological processes. Lately, a subclass of glycerophospholipids, namely plasmalogens, has received increased attention due to their association with several degenerative and metabolic disorders as well as aging. All these pathophysiological conditions involve chronic inflammatory processes, which have been linked with decreased levels of plasmalogens. Currently, there is a lack of full understanding of the molecular mechanisms governing the association of plasmalogens with inflammation. However, it has been shown that in inflammatory processes, plasmalogens could trigger either an anti- or pro-inflammation response. While the anti-inflammatory response seems to be linked to the entire plasmalogen molecule, its pro-inflammatory response seems to be associated with plasmalogen hydrolysis,

Identifiants

pubmed: 34744771
doi: 10.3389/fphys.2021.730829
pmc: PMC8566352
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

730829

Informations de copyright

Copyright © 2021 Bozelli, Azher and Epand.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

José Carlos Bozelli (JC)

Department of Biochemistry and Biomedical Sciences, Health Sciences Centre, McMaster University, Hamilton, ON, Canada.

Sayed Azher (S)

Department of Biochemistry and Biomedical Sciences, Health Sciences Centre, McMaster University, Hamilton, ON, Canada.

Richard M Epand (RM)

Department of Biochemistry and Biomedical Sciences, Health Sciences Centre, McMaster University, Hamilton, ON, Canada.

Classifications MeSH