Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin.

Immune modulating therapies and vaccines are in high demand, not least to the recent global spread of SARS-CoV2. To achieve efficient activation of the immune system, professional antigen presenting cells have proven to be key coordinators of such responses. Especially targeted approaches, actively directing antigens to specialized dendritic cells, promise to be more effective and accompanied by reduced payload due to less off-target effects. Although antibody and glycan-based targeting of receptors on dendritic cells have been employed, these are often expensive and time-consuming to manufacture or lack sufficient specificity. Thus, we applied a small-molecule ligand that specifically binds Langerin, a hallmark receptor on Langerhans cells, conjugated to a model protein antigen.

Informations de copyright

Copyright © 2021 Rentzsch, Wawrzinek, Zelle-Rieser, Strandt, Bellmann, Fuchsberger, Schulze, Busmann, Rademacher, Sigl, Del Frari, Stoitzner and Rademacher.

Déclaration de conflit d'intérêts

The authors declare the following competing financial interest(s): RW, JS, and CR declare the filing of a patent covering the use of Langerin targeting ligands. RW and CR are shareholders of Cutanos GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.