Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis.

Animals Granuloma / immunology Host-Pathogen Interactions Humans Inflammation / immunology Lung / pathology Macrophages / immunology Molecular Targeted Therapy Mycobacterium tuberculosis / physiology Neutrophils / immunology Tuberculosis / immunology
granuloma host-directed drug therapy inflammation lung pathology tuberculosis

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 30 06 2021
accepted: 01 10 2021
entrez: 8 11 2021
pubmed: 9 11 2021
medline: 29 12 2021
Statut: epublish

Résumé

Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the world threatens national TB control programs. This requires an understanding of host-pathogen interactions and finding novel treatments including host-directed therapies (HDTs) is of utter importance to tackle the TB epidemic.

Identifiants

DOI: 10.3389/fimmu.2021.733853 PMID: 34745105 PMC: PMC8563828
pubmed: 34745105
doi: 10.3389/fimmu.2021.733853
pmc: PMC8563828
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

733853

Subventions

Organisme : Medical Research Council
ID : MR/P028071/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI160501
Pays : United States
Organisme : Wellcome Trust
ID : 203135Z/16/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2021 Guler, Ozturk, Sabeel, Motaung, Parihar, Thienemann and Brombacher.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Reto Guler (R)

International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.
Department of Pathology, University of Cape Town, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Mumin Ozturk (M)

International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.
Department of Pathology, University of Cape Town, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Solima Sabeel (S)

International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.
Department of Pathology, University of Cape Town, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Bongani Motaung (B)

International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.
Department of Pathology, University of Cape Town, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Suraj P Parihar (SP)

International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.
Department of Pathology, University of Cape Town, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Friedrich Thienemann (F)

General Medicine & Global Health, Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Department of Internal Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Frank Brombacher (F)

International Centre for Genetic Engineering and Biotechnology, Cape Town Component, Cape Town, South Africa.
Department of Pathology, University of Cape Town, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Granulome › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Appareil respiratoire › Poumon › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Targeting Molecular Inflammatory Pathways in...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Targeting Molecular Inflammatory Pathways in...