Genome-scale actions of master regulators directing skeletal development.
Chondrocytes
Osteoblasts
Runx2
Sox9
Sp7
Transcription
Journal
The Japanese dental science review
ISSN: 1882-7616
Titre abrégé: Jpn Dent Sci Rev
Pays: Netherlands
ID NLM: 101481371
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
22
06
2021
revised:
14
09
2021
accepted:
10
10
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
ppublish
Résumé
The mammalian skeleton develops through two distinct modes of ossification: intramembranous ossification and endochondral ossification. During the process of skeletal development, SRY-box containing gene 9 (Sox9), runt-related transcription factor 2 (Runx2), and Sp7 work as master transcription factors (TFs) or transcriptional regulators, underlying cell fate specification of the two distinct populations: bone-forming osteoblasts and cartilage-forming chondrocytes. In the past two decades, core transcriptional circuits underlying skeletal development have been identified mainly through mouse genetics and biochemical approaches. Recently emerging next-generation sequencer (NGS)-based studies have provided genome-scale views on the gene regulatory landscape programmed by the master TFs/transcriptional regulators. With particular focus on Sox9, Runx2, and Sp7, this review aims to discuss the gene regulatory landscape in skeletal development, which has been identified by genome-scale data, and provide future perspectives in this field.
Identifiants
pubmed: 34745394
doi: 10.1016/j.jdsr.2021.10.001
pii: S1882-7616(21)00028-4
pmc: PMC8556520
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
217-223Informations de copyright
© 2021 The Author.
Références
J Bone Miner Res. 2002 Jun;17(6):1008-14
pubmed: 12054155
Nat Genet. 1997 Jul;16(3):307-10
pubmed: 9207800
Nucleic Acids Res. 2015 Sep 30;43(17):8183-203
pubmed: 26150426
J Bone Miner Res. 2011 Apr;26(4):777-91
pubmed: 20939017
Cell Res. 2021 Jul;31(7):742-757
pubmed: 33473154
PLoS Genet. 2011 Nov;7(11):e1002356
pubmed: 22072985
Dev Cell. 2012 Mar 13;22(3):597-609
pubmed: 22421045
J Cell Biol. 2010 Dec 27;191(7):1271-83
pubmed: 21173110
Dev Cell. 2001 Aug;1(2):277-90
pubmed: 11702786
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13030-5
pubmed: 9789035
Cell. 1997 May 30;89(5):765-71
pubmed: 9182764
Cell. 1997 May 30;89(5):747-54
pubmed: 9182762
Genome Res. 2012 Sep;22(9):1798-812
pubmed: 22955990
Nat Genet. 2002 Dec;32(4):639-44
pubmed: 12434156
Science. 2005 Aug 12;309(5737):1074-8
pubmed: 16099986
Science. 2006 May 26;312(5777):1223-7
pubmed: 16728642
Mol Cell Biol. 1995 Apr;15(4):1858-69
pubmed: 7891679
J Biol Chem. 2016 Aug 19;291(34):17829-47
pubmed: 27402842
J Biol Chem. 2014 Sep 26;289(39):27105-27117
pubmed: 25122769
Ann Rheum Dis. 2019 Jan;78(1):100-110
pubmed: 30026257
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4936-42
pubmed: 15788537
Bone. 2018 May;110:66-75
pubmed: 29382611
Nat Genet. 1999 May;22(1):85-9
pubmed: 10319868
Stem Cells. 2014 Oct;32(10):2780-93
pubmed: 24898411
Genes Dev. 2004 May 1;18(9):1072-87
pubmed: 15132997
Eur J Cancer. 2005 Nov;41(16):2438-48
pubmed: 16209919
J Mol Histol. 2017 Aug;48(4):321-327
pubmed: 28687932
Nat Commun. 2021 Jan 13;12(1):362
pubmed: 33441552
Dev Cell. 2018 Sep 24;46(6):794-806.e6
pubmed: 30146478
J Clin Invest. 2001 Feb;107(3):295-304
pubmed: 11160153
Connect Tissue Res. 2014 Aug;55 Suppl 1:83-7
pubmed: 25158187
Genes Dev. 2002 Nov 1;16(21):2813-28
pubmed: 12414734
Nucleic Acids Res. 2015 Jan;43(Database issue):D117-22
pubmed: 25378322
Cell Rep. 2015 Jul 14;12(2):229-43
pubmed: 26146088
Dev Cell. 2016 May 9;37(3):238-53
pubmed: 27134141
Dev Biol. 2008 Apr 15;316(2):458-70
pubmed: 18280462
Genome Biol. 2014 Mar 21;15(3):R52
pubmed: 24655370
J Bone Miner Res. 2015 Apr;30(4):742-6
pubmed: 25349111
Cell. 2013 Apr 11;153(2):307-19
pubmed: 23582322
Cell. 2006 Jun 2;125(5):971-86
pubmed: 16751105
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8650-5
pubmed: 11438701
Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):
pubmed: 33597301
PLoS One. 2009;4(2):e4543
pubmed: 19229324
Development. 2011 Apr;138(8):1507-19
pubmed: 21367821
Nucleic Acids Res. 2012 Sep;40(16):7844-57
pubmed: 22684502
Oncogene. 2004 May 24;23(24):4315-29
pubmed: 15156188
Science. 1969 Jul 25;165(3891):349-57
pubmed: 5789433
Dev Cell. 2010 Aug 17;19(2):329-44
pubmed: 20708594
Int J Biochem Cell Biol. 2010 Mar;42(3):429-32
pubmed: 19647094
Cell. 1994 Dec 16;79(6):1111-20
pubmed: 8001137
Arch Histol Cytol. 2008 Sep;71(2):131-46
pubmed: 18974605
Cell. 1998 Jun 12;93(6):985-96
pubmed: 9635428
Hum Mol Genet. 2003 Jun 15;12(12):1439-47
pubmed: 12783851
Nat Commun. 2016 Apr 01;7:11149
pubmed: 27033977
Cell. 2002 Jan 11;108(1):17-29
pubmed: 11792318
Nat Genet. 2002 Dec;32(4):633-8
pubmed: 12434152
Cell. 1997 May 30;89(5):773-9
pubmed: 9182765
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3545-50
pubmed: 26969725
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9360-5
pubmed: 12878728
J Dent Res. 2009 Oct;88(10):904-9
pubmed: 19783797
J Bone Miner Res. 2012 May;27(5):1080-92
pubmed: 22246569
Nature. 2015 May 21;521(7552):366-70
pubmed: 25799994
Development. 2016 Aug 15;143(16):3012-23
pubmed: 27471255
J Biol Chem. 2012 Sep 28;287(40):33179-90
pubmed: 22869368
Connect Tissue Res. 2017 Jan;58(1):2-14
pubmed: 27128146
Mech Dev. 2002 Dec;119 Suppl 1:S107-10
pubmed: 14516670
Development. 2018 Jul 18;145(14):
pubmed: 30021842
Cell. 1997 May 30;89(5):755-64
pubmed: 9182763
Dev Cell. 2004 Mar;6(3):423-35
pubmed: 15030764
Development. 1999 Jul;126(13):2911-20
pubmed: 10357935
Nucleic Acids Res. 2013 Jan;41(Database issue):D165-70
pubmed: 23180794
J Bone Miner Metab. 2011 Jul;29(4):390-5
pubmed: 21594584
Genes Dev. 2014 Dec 15;28(24):2679-92
pubmed: 25512556
JBMR Plus. 2018 Mar;2(2):81-91
pubmed: 30035248
PLoS One. 2014 Sep 17;9(9):e107577
pubmed: 25229425
Mol Cell Biol. 2004 Oct;24(20):9248-61
pubmed: 15456894
Hum Mol Genet. 2003 Jul 15;12(14):1755-65
pubmed: 12837698
Genes Dev. 2012 May 1;26(9):908-13
pubmed: 22499593
Genes Dev. 2003 Aug 15;17(16):1979-91
pubmed: 12923053
Bone. 2014 Apr;61:132-7
pubmed: 24444803
Nature. 1994 Dec 8;372(6506):525-30
pubmed: 7990924
Arthritis Rheum. 2004 Nov;50(11):3561-73
pubmed: 15529345
Am J Hum Genet. 2010 Jul 9;87(1):110-4
pubmed: 20579626
BMC Genomics. 2019 May 22;20(1):401
pubmed: 31117954
Elife. 2021 Jan 27;10:
pubmed: 33501917
Mol Biol Cell. 2008 Dec;19(12):5373-86
pubmed: 18843047
Genes Dev. 2004 Apr 15;18(8):952-63
pubmed: 15107406
J Biol Chem. 2014 Jun 6;289(23):16016-31
pubmed: 24764292