Severe Lactic Acidosis in a Critically Ill Child: Think About Thiamine! A Case Report.
critically ill child
lactic acidosis
thiamine deficiency
Journal
Journal of pediatric intensive care
ISSN: 2146-4618
Titre abrégé: J Pediatr Intensive Care
Pays: Germany
ID NLM: 101592756
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
17
02
2020
accepted:
14
05
2020
entrez:
8
11
2021
pubmed:
15
7
2020
medline:
15
7
2020
Statut:
epublish
Résumé
In this article, we presented a teenager, in maintenance chemotherapy for leukemia, who was admitted for digestive symptoms related to a parasitic infection and required nutritional support with parenteral nutrition. After 6 weeks, his condition worsened with refractory shock of presumed septic origin, necessitating extracorporeal membrane oxygenation. Despite hemodynamic stabilization, his lactic acidosis worsened until thiamine supplementation was started. Lactate normalized within 12 hours. Thiamine is an essential coenzyme in aerobic glycolysis, and deficiency leads to lactate accumulation through anaerobic glycolysis. Thiamine deficiency is uncommon in the pediatric population. However, it should be considered in patients at risk of nutritional deficiencies with lactic acidosis of unknown origin.
Identifiants
pubmed: 34745706
doi: 10.1055/s-0040-1713382
pii: 2000027
pmc: PMC8561793
doi:
Types de publication
Case Reports
Langues
eng
Pagination
307-310Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of Interest None declared.
Références
Clin Chem Lab Med. 2017 Oct 26;55(11):1652-1668
pubmed: 28432843
Crit Care Med. 2016 Feb;44(2):360-7
pubmed: 26771781
World J Pediatr. 2010 Nov;6(4):366-8
pubmed: 20127217
Am J Med Sci. 2018 Oct;356(4):382-390
pubmed: 30146080
J Crit Care. 2010 Dec;25(4):576-81
pubmed: 20646908
J Pediatr Hematol Oncol. 2003 Dec;25(12):965-8
pubmed: 14663281
Nutr Clin Pract. 2015 Feb;30(1):104-10
pubmed: 25516536
Nutr Clin Pract. 2012 Feb;27(1):41-50
pubmed: 22223666
Circ J. 2010 Sep;74(9):1983-5
pubmed: 20622473
Case Rep Crit Care. 2017;2017:5121032
pubmed: 29119026
Medicine (Baltimore). 2007 Jul;86(4):225-232
pubmed: 17632264
Cancer. 2001 Nov 1;92(9):2237-46
pubmed: 11745277
Pediatrics. 2005 Feb;115(2):e233-8
pubmed: 15687431
BMJ Case Rep. 2014 Jun 03;2014:
pubmed: 24895398
Am J Clin Nutr. 2011 Jan;93(1):57-61
pubmed: 21068344
Am J Emerg Med. 2017 Mar;35(3):521.e1-521.e2
pubmed: 27751597
Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):610-7
pubmed: 21912244
Nutr J. 2015 May 17;14:51
pubmed: 25982313
Pediatrics. 2015 Jan;135(1):e221-4
pubmed: 25548327
N Am J Med Sci. 2012 Oct;4(10):503-6
pubmed: 23112976
Postgrad Med J. 2001 Sep;77(911):582-5
pubmed: 11524517
Crit Care. 2011;15(6):457
pubmed: 22129138
Intensive Care Med. 2018 Nov;44(11):1940-1944
pubmed: 29520660
JPEN J Parenter Enteral Nutr. 2016 Aug;40(6):886-9
pubmed: 25591974
Nutrition. 2018 Apr;48:105-110
pubmed: 29469010