Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins.
biochemical screening
coronavirus
drug repositioning
protein structure
virtual screening
Journal
Biophysics and physicobiology
ISSN: 2189-4779
Titre abrégé: Biophys Physicobiol
Pays: Japan
ID NLM: 101675089
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
08
2021
accepted:
30
09
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
More than one and half years have passed, as of August 2021, since the COVID-19 caused by the novel coronavirus named SARS-CoV-2 emerged in 2019. While the recent success of vaccine developments likely reduces the severe cases, there is still a strong requirement of safety and effective therapeutic drugs for overcoming the unprecedented situation. Here we review the recent progress and the status of the drug discovery against COVID-19 with emphasizing a structure-based perspective. Structural data regarding the SARS-CoV-2 proteome has been rapidly accumulated in the Protein Data Bank, and up to 68% of the total amino acid residues encoded in the genome were covered by the structural data. Despite a global effort of
Identifiants
pubmed: 34745807
doi: 10.2142/biophysico.bppb-v18.025
pii: JST.JSTAGE/biophysico/bppb-v18.025
pmc: PMC8550875
doi:
Types de publication
Journal Article
Langues
eng
Pagination
226-240Informations de copyright
2021 THE BIOPHYSICAL SOCIETY OF JAPAN.
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