Aberrant Phase Separation of FUS Leads to Lysosome Sequestering and Acidification.
ALS
FUS
lyso-pHluorin
lysosomes
optodroplets
phase separation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
05
2021
accepted:
17
09
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to the death of upper and lower motor neurons. While most cases of ALS are sporadic, some of the familial forms of the disease are caused by mutations in the gene encoding for the RNA-binding protein FUS. Under physiological conditions, FUS readily phase separates into liquid-like droplets
Identifiants
pubmed: 34746121
doi: 10.3389/fcell.2021.716919
pmc: PMC8569517
doi:
Types de publication
Journal Article
Langues
eng
Pagination
716919Informations de copyright
Copyright © 2021 Trnka, Hoffmann, Wang, Sansevrino, Rankovic, Rost, Schmitz, Schmidt and Milovanovic.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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