Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS.
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
05
2021
revised:
06
10
2021
accepted:
12
10
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
27
1
2022
Statut:
epublish
Résumé
The main dose-limiting side effect of cisplatin is nephrotoxicity. The utilization of cisplatin is an issue of balancing tumour toxicity versus platinum-induced nephrotoxicity. In this study, we focused on intraorgan distribution of common essential trace elements zinc, copper, and iron in healthy mouse kidneys and distribution of platinum after cisplatin treatment. Renal distribution in 12 nontreated Nu-Nu mice (males) was assessed by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Furthermore, 9 Nu-Nu mice were treated with cisplatin. The order of elements concentration in kidneys was as follows: Fe > Zn > Cu. All three metals showed the higher concentrations at the cortex and medulla (28.60, 3.35, and 93.83
Identifiants
pubmed: 34746306
doi: 10.1155/2021/6800294
pmc: PMC8564192
doi:
Substances chimiques
Platinum
49DFR088MY
Copper
789U1901C5
Iron
E1UOL152H7
Zinc
J41CSQ7QDS
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6800294Informations de copyright
Copyright © 2021 Petr Stepka et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
Références
Metallomics. 2015 Aug;7(8):1256-64
pubmed: 25856224
Metallomics. 2013 Oct;5(10):1440-7
pubmed: 23934158
Clin J Am Soc Nephrol. 2009 Jul;4(7):1275-83
pubmed: 19520747
Semin Nephrol. 2003 Sep;23(5):460-4
pubmed: 13680535
J Pharmacol Exp Ther. 1980 Jun;213(3):551-6
pubmed: 7193726
Nephrol Dial Transplant. 1997 Dec;12(12):2478-80
pubmed: 9430835
Urology. 2006 Jun;67(6):1341-7
pubmed: 16765200
J Nutr. 2006 Jan;136(1):21-6
pubmed: 16365053
Clin Chem. 1972 Jan;18(1):67-72
pubmed: 5007535
Sci Rep. 2017 Mar 16;7:44804
pubmed: 28300186
Anticancer Res. 2014 Jan;34(1):547-50
pubmed: 24403515
Am J Physiol Renal Physiol. 2009 Mar;296(3):F505-11
pubmed: 19144690
Chem Sci. 2016 May 1;7(5):3052-3061
pubmed: 29997796
Eur J Pharmacol. 2014 Oct 5;740:364-78
pubmed: 25058905
Anal Chim Acta. 2016 Sep 28;938:106-13
pubmed: 27619092
FEBS Lett. 1999 Nov 19;461(3):339-42
pubmed: 10567723
Metallomics. 2015 Feb;7(2):267-76
pubmed: 25561341
J Nutr. 1999 Jul;129(7):1251-60
pubmed: 10395584
Nephron Physiol. 2005;99(4):p105-10
pubmed: 15722646
Kidney Int. 2007 Jul;72(1):53-62
pubmed: 17410096
Metallomics. 2014 Sep;6(9):1616-25
pubmed: 24823867
Kidney Int. 1984 May;25(5):753-8
pubmed: 6540826
Nat Commun. 2017 Nov 21;8(1):1654
pubmed: 29162831
Sci Rep. 2017 Jan 10;7:40169
pubmed: 28071735
J Biomed Sci. 2019 Mar 13;26(1):25
pubmed: 30866950
Electrophoresis. 2019 Sep;40(18-19):2329-2335
pubmed: 31087392
Drug Resist Updat. 2011 Feb;14(1):22-34
pubmed: 21251871