Risk for Colorectal Cancer in Patients with Serially Positive Fecal Immunochemistry Test in an Annual Screening Program.
cancer screening
colonic neoplasms
colonoscopy
colorectal neoplasms
occult blood
Journal
Journal of the anus, rectum and colon
ISSN: 2432-3853
Titre abrégé: J Anus Rectum Colon
Pays: Japan
ID NLM: 101718055
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
11
2020
accepted:
11
05
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
There are patients who do not undergo colonoscopy even if the fecal immunochemistry test (FIT) results are positive and even with repeated positive test results the following year. We aimed to investigate colorectal cancer (CRC) risk in examinees with positive FIT results in our annual screening program. We analyzed patients who underwent initial colonoscopy from April 2010 to March 2017 because of positive FIT results using an endoscopy database in our hospital. We investigated the difference in the risk of advanced colorectal neoplasia as a surrogate marker of CRC between those who had an initial positive test and those who had repeated positive tests. A total of 748 patients were included in this analysis. The advanced neoplasia detection rates were 7.6% (50/656) and 18.5% (17/92) for the initial and repeated positive test groups, respectively. Subgroup analysis of those with repeated positive tests revealed that the detection rates in examinees with positive tests 1-2 and >2 years ago were 16.7% (6/36) and 19.6% (11/56), respectively. The odds ratios for advanced neoplasia detection in patients with positive tests 1-2 and >2 years ago compared with those in the initial positive test group were 2.72 (95% confidence interval [CI], 1.04-7.10) and 3.09 (95% CI, 1.47-6.48), respectively. The risk of CRC appears more than doubled in patients with a repeated positive FIT result. Prompt colonoscopy is recommended for FIT-positive cases.
Identifiants
pubmed: 34746498
doi: 10.23922/jarc.2020-094
pmc: PMC8553357
doi:
Types de publication
Journal Article
Langues
eng
Pagination
340-345Informations de copyright
Copyright © 2021 by The Japan Society of Coloproctology.
Déclaration de conflit d'intérêts
Conflicts of Interest There are no conflicts of interest.
Références
Lancet. 1996 Nov 30;348(9040):1467-71
pubmed: 8942774
JAMA. 2003 Dec 10;290(22):2959-67
pubmed: 14665657
Int J Colorectal Dis. 2020 May;35(5):933-939
pubmed: 32034490
Dig Liver Dis. 2020 Aug;52(8):808-815
pubmed: 32425733
Clin Gastroenterol Hepatol. 2016 Oct;14(10):1445-1451.e8
pubmed: 27211498
Gut. 2011 Sep;60(9):1236-41
pubmed: 21402615
Gastroenterology. 2004 Jun;126(7):1674-80
pubmed: 15188160
N Engl J Med. 1993 May 13;328(19):1365-71
pubmed: 8474513
N Engl J Med. 2000 Nov 30;343(22):1603-7
pubmed: 11096167
Lancet Oncol. 2020 Jul;21(7):e338
pubmed: 32615111
Lancet. 1996 Nov 30;348(9040):1472-7
pubmed: 8942775
J Gastroenterol. 2018 Oct;53(10):1109-1119
pubmed: 29359244
Endoscopy. 2020 Oct;52(10):871-876
pubmed: 32356282
J Gastroenterol Hepatol. 2018 Jan;33(1):187-194
pubmed: 28561279
JAMA. 2017 Apr 25;317(16):1631-1641
pubmed: 28444278
Cancer. 2015 Sep 15;121(18):3221-9
pubmed: 25995082
Clin Gastroenterol Hepatol. 2019 Jun;17(7):1332-1340.e3
pubmed: 30391435
JGH Open. 2020 Apr 16;4(5):898-902
pubmed: 33102761
Lancet Gastroenterol Hepatol. 2021 Apr;6(4):304-314
pubmed: 33548185
Am J Gastroenterol. 2018 Dec;113(12):1788-1800
pubmed: 30315282