Cannabidiol-Mediated Green Synthesis, Characterization, and Cytotoxicity of Metal Nanoparticles in Human Keratinocyte Cells.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
02 Nov 2021
02 Nov 2021
Historique:
received:
10
08
2021
accepted:
24
09
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
This study investigated a unique one-pot microwave-assisted green synthesis method of gold (Au) and silver (Ag) nanoparticles (NPs) using cannabidiol (CBD) as a capping and reducing agent. Furthermore, Au and Ag NPs were also chemically synthesized using poly(vinyl pyrrolidone), which functioned as reference materials when comparing the size, shape, and cytotoxicity of NPs. Synthesis parameters such as reaction time, temperature, and precursor molar ratio were optimized to control the size and shape of the biosynthesized NPs. Various characterization techniques such as transmission electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction were used to confirm the formation and properties of Au and Ag NPs. Both biosynthesized metal NPs were spherical and monodispersed, with average particle sizes of 8.4 nm (Au-CBD) and 4.8 nm (Ag-CBD). This study also explored the potential cytotoxicity of CBD-capped NPs in human keratinocyte cells, which was observed to be of minimal concern. The novel synthesis approach presented in this study is free from harsh chemical reagents; therefore, these NPs can be used in a wide array of applications, including the pharmaceutical and biomedical fields.
Identifiants
pubmed: 34746597
doi: 10.1021/acsomega.1c04303
pmc: PMC8567371
doi:
Types de publication
Journal Article
Langues
eng
Pagination
29078-29090Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Cancer Lett. 2015 Feb 1;357(1):8-42
pubmed: 25444899
Int J Nanomedicine. 2017 Dec 13;12:8813-8830
pubmed: 29263670
Pharmacol Ther. 2017 Jul;175:133-150
pubmed: 28232276
Nanomedicine. 2015 Jul;11(5):1265-75
pubmed: 25804413
Chem Rev. 2011 Jun 8;111(6):3828-57
pubmed: 21648956
Res Pharm Sci. 2014 Nov-Dec;9(6):385-406
pubmed: 26339255
Int J Nanomedicine. 2018 Jun 21;13:3571-3591
pubmed: 29950836
Artif Cells Nanomed Biotechnol. 2018;46(sup3):S336-S343
pubmed: 30043657
Crit Rev Ther Drug Carrier Syst. 1992;9(1):39-90
pubmed: 1544174
Clin Pharmacol Ther. 2015 Jun;97(6):575-86
pubmed: 25777363
ACS Nano. 2010 Dec 28;4(12):7481-91
pubmed: 21082814
Nat Mater. 2008 Jun;7(6):442-53
pubmed: 18497851
J Nanobiotechnology. 2012 May 01;10:17
pubmed: 22548753
Sci Rep. 2017 Jun 23;7(1):4131
pubmed: 28646143
Dalton Trans. 2015 Nov 7;44(41):17883-905
pubmed: 26434727
Molecules. 2018 Dec 28;24(1):
pubmed: 30597856
Biointerphases. 2007 Dec;2(4):MR17-71
pubmed: 20419892
Acta Dermatovenerol Croat. 2007;15(2):80-3
pubmed: 17631786
Chem Commun (Camb). 2013 May 11;49(38):3991-3
pubmed: 23552222
Expert Opin Drug Deliv. 2009 Nov;6(11):1175-94
pubmed: 19743894
ChemMedChem. 2007 Jan;2(1):129-36
pubmed: 17075952
Biomolecules. 2020 Feb 03;10(2):
pubmed: 32028623
Saudi Pharm J. 2016 Jul;24(4):473-84
pubmed: 27330378
J Food Drug Anal. 2018 Apr;26(2):649-656
pubmed: 29567234
Chem Soc Rev. 2006 Jul;35(7):583-92
pubmed: 16791330
J Pharmacol Exp Ther. 2006 Sep;318(3):1375-87
pubmed: 16728591
J Oncol. 2020 Jul 13;2020:5194780
pubmed: 32765604
Sci Rep. 2017 Mar 28;7:45292
pubmed: 28349970
Expert Opin Biol Ther. 2003 Jul;3(4):655-63
pubmed: 12831370
J Clin Invest. 2014 Sep;124(9):3713-24
pubmed: 25061872
Nanomaterials (Basel). 2018 Jan 21;8(1):
pubmed: 29361727
Pharmaceutics. 2015 Oct 22;7(4):438-70
pubmed: 26506371
Expert Opin Drug Deliv. 2017 Jan;14(1):109-122
pubmed: 27348356
Anal Chim Acta. 2011 Nov 7;706(1):8-24
pubmed: 21995909
Nanoscale Res Lett. 2011 Jun 22;6:434
pubmed: 21711498
Pediatr Dermatol. 2018 Jul;35(4):e224-e227
pubmed: 29786144
Indian Dermatol Online J. 2013 Oct;4(4):267-72
pubmed: 24350003
Redox Biol. 2020 Jan;28:101321
pubmed: 31518892
Molecules. 2016 Dec 15;21(12):
pubmed: 27983701
Nanoscale Res Lett. 2014 Nov 23;9(1):627
pubmed: 25489281
Nanoscale Res Lett. 2012 Feb 22;7(1):151
pubmed: 22356679
Small. 2007 Jun;3(6):1023-31
pubmed: 17455182
Hum Exp Toxicol. 2015 Dec;34(12):1318-21
pubmed: 26614822
Sci Rep. 2016 Feb 02;6:20414
pubmed: 26829907
Chem Biol Interact. 2018 Nov 1;295:38-51
pubmed: 28641964