An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients.
Biological sciences
Neuroscience
Omics
Systems biology
Systems neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
received:
02
03
2021
revised:
29
06
2021
accepted:
30
09
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Neurodegenerative diseases are challenging for systems biology because of the lack of reliable animal models or patient samples at early disease stages. Induced pluripotent stem cells (iPSCs) could address these challenges. We investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with ALS carrying hexanucleotide expansions in
Identifiants
pubmed: 34746695
doi: 10.1016/j.isci.2021.103221
pii: S2589-0042(21)01189-5
pmc: PMC8554488
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103221Subventions
Organisme : NINDS NIH HHS
ID : K08 NS104273
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM087237
Pays : United States
Investigateurs
Hemali Phatnani
(H)
Justin Kwan
(J)
Dhruv Sareen
(D)
James R Broach
(JR)
Zachary Simmons
(Z)
Ximena Arcila-Londono
(X)
Edward B Lee
(EB)
Vivianna M Van Deerlin
(VM)
Neil A Shneider
(NA)
Ernest Fraenkel
(E)
Lyle W Ostrow
(LW)
Frank Baas
(F)
Noah Zaitlen
(N)
James D Berry
(JD)
Andrea Malaspina
(A)
Pietro Fratta
(P)
Gregory A Cox
(GA)
Leslie M Thompson
(LM)
Steve Finkbeiner
(S)
Efthimios Dardiotis
(E)
Timothy M Miller
(TM)
Siddharthan Chandran
(S)
Suvankar Pal
(S)
Eran Hornstein
(E)
Daniel J MacGowan
(DJ)
Terry Heiman-Patterson
(T)
Molly G Hammell
(MG)
Nikolaos A Patsopoulos
(NA)
Oleg Butovsky
(O)
Joshua Dubnau
(J)
Avindra Nath
(A)
Robert Bowser
(R)
Matt Harms
(M)
Mary Poss
(M)
Jennifer Phillips-Cremins
(J)
John Crary
(J)
Nazem Atassi
(N)
Dale J Lange
(DJ)
Darius J Adams
(DJ)
Leonidas Stefanis
(L)
Marc Gotkine
(M)
Robert H Baloh
(RH)
Suma Babu
(S)
Towfique Raj
(T)
Sabrina Paganoni
(S)
Ophir Shalem
(O)
Colin Smith
(C)
Bin Zhang
(B)
Brent Harris
(B)
Iris Broce
(I)
Vivian Drory
(V)
John Ravits
(J)
Corey McMillan
(C)
Vilas Menon
(V)
Lani Wu
(L)
Steven Altschuler
(S)
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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