IL-1beta promotes the age-associated decline of beta cell function.
Cell biology
Cellular physiology
Physiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 Nov 2021
19 Nov 2021
Historique:
received:
24
05
2021
revised:
03
09
2021
accepted:
07
10
2021
entrez:
8
11
2021
pubmed:
9
11
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreased in islets, whereas IL-1beta gene expression increased specifically in the CD45 + islet immune cell fraction. One-year-old mice with a whole-body knockout of IL-1beta had higher insulin secretion
Identifiants
pubmed: 34746709
doi: 10.1016/j.isci.2021.103250
pii: S2589-0042(21)01219-0
pmc: PMC8554531
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103250Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
M.Y.D. is listed as the inventor on a patent filed in 2003 for the use of an IL-1 receptor antagonist for the treatment of or prophylaxis for type 2 diabetes.
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