Artemisinin Cocrystals for Bioavailability Enhancement. Part 2:

Animals Artemisinins / chemistry Biological Availability Crystallization Dose-Response Relationship, Drug Drug Liberation Female Mice Mice, Inbred BALB C Models, Biological
PBPK modeling artemisinin parasitaemia pharmaceutical cocrystal pharmacokinetics

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
06 12 2021
Historique:
pubmed: 9 11 2021
medline: 15 3 2022
entrez: 8 11 2021
Statut: ppublish

Résumé

We report the evaluation and prediction of the pharmacokinetic (PK) performance of artemisinin (ART) cocrystal formulations, that is, 1:1 artemisinin/orcinol (ART-ORC) and 2:1 artemisinin/resorcinol (ART

Identifiants

DOI: 10.1021/acs.molpharmaceut.1c00385 PMID: 34748332
pubmed: 34748332
doi: 10.1021/acs.molpharmaceut.1c00385
doi:

Substances chimiques

Artemisinins 0
artemisinin 9RMU91N5K2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4272-4289

Auteurs

Manreet Kaur (M)

Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, U.K.

Vanessa Yardley (V)

Department of Infection & Immunity, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.

Ke Wang (K)

Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, U.K.

Jinit Masania (J)

Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, U.K.

Randolph R J Arroo (RRJ)

Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, U.K.
ORCID: 0000-0002-0672-7927

David B Turner (DB)

Certara UK Limited, Simcyp Division, Sheffield S1 2BJ, U.K.

Mingzhong Li (M)

Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, U.K.
ORCID: 0000-0002-9532-9049

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Phénomènes chimiques › Cristallisation › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Artemisinin Cocrystals for Bioavailability...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Artemisinin Cocrystals for Bioavailability...