Efficacy and histopathological effects of self-assembling peptides RADA16 and IEIK13 in neurosurgical hemostasis.
Hemostasis
Histopathology
Nanohemostat
Neurosurgery
Self-assembling peptide
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
25
06
2021
revised:
13
09
2021
accepted:
25
10
2021
pubmed:
9
11
2021
medline:
8
4
2022
entrez:
8
11
2021
Statut:
ppublish
Résumé
There is a continued need for effective hemostatic agents that are safe for neurosurgical use. Self-assembling peptide hydrogels have been suggested as novel hemostatic agents. They offer some advantages for neurosurgical hemostasis (e.g., transparency), but their efficacy and safety for neurosurgery have not been established. In this paper, the efficacy and safety of two self-assembling peptides, RADA16 and IEIK13, are explored for hemostasis of oozing bleeding on the rat cerebral cortex (n = 56). Chronic safety was evaluated by neuropathological evaluation at one, four, and twelve weeks after craniotomy (n = 32). An inactive control and oxidized cellulose served as comparators. Mean time-to-hemostasis was significantly shorter for RADA16 and IEIK13 compared to controls, while safety evaluation yielded similar results. Histopathological response consisted primarily of macrophage infiltration at the lesion site in all groups. This study confirms the hemostatic potential and safety of RADA16 and IEIK13 for hemostasis in the rat brain.
Identifiants
pubmed: 34748959
pii: S1549-9634(21)00128-3
doi: 10.1016/j.nano.2021.102485
pii:
doi:
Substances chimiques
Hemostatics
0
Hydrogels
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102485Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.