Therapeutic vaccination strategies against EBOV by rVSV-EBOV-GP: the role of innate immunity.
Journal
Current opinion in virology
ISSN: 1879-6265
Titre abrégé: Curr Opin Virol
Pays: Netherlands
ID NLM: 101560941
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
24
06
2021
revised:
14
10
2021
accepted:
19
10
2021
pubmed:
9
11
2021
medline:
3
2
2022
entrez:
8
11
2021
Statut:
ppublish
Résumé
Zaire Ebola virus (EBOV) is a member of the Filoviridae family. Infection with EBOV causes Ebola virus disease (EVD) characterized by excessive inflammation, lymphocyte death, coagulopathy, and multi-organ failure. In 2019, the FDA-approved the first anti-EBOV vaccine, rVSV-EBOV-GP (Ervebo® by Merck). This live-recombinant vaccine confers both prophylactic and therapeutic protection to nonhuman primates and humans. While mechanisms conferring prophylactic protection are well-investigated, those underlying protection conferred shortly before and after exposure to EBOV remain poorly understood. In this review, we review data from in vitro and in vivo studies analyzing early immune responses to rVSV-EBOV-GP and discuss the role of innate immune activation in therapeutic protection.
Identifiants
pubmed: 34749265
pii: S1879-6257(21)00129-2
doi: 10.1016/j.coviro.2021.10.007
pmc: PMC8884032
mid: NIHMS1780005
pii:
doi:
Substances chimiques
Ebola Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-189Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI143301
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
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