MicroRNAs in Helminth Parasites: A Systematic Review.

Animals Helminths / genetics MicroRNAs / genetics Parasites / genetics RNA, Helminth / genetics
MicroRNA cestode helminth nematode parasites trematode

Journal

Current molecular medicine
ISSN: 1875-5666
Titre abrégé: Curr Mol Med
Pays: Netherlands
ID NLM: 101093076

Informations de publication

Date de publication:
2022
Historique:
received: 27 01 2021
revised: 05 05 2021
accepted: 10 06 2021
pubmed: 10 11 2021
medline: 18 6 2022
entrez: 9 11 2021
Statut: ppublish

Résumé

MicroRNAs (miRNAs) are about 22-nucleotide, small, noncoding RNAs that control gene expression post-transcriptionally. Helminth parasites usually express a unique repertoire of genes, including miRNAs, across different developmental stages with subtle regulatory mechanisms. There is a necessity to investigate the involvement of miRNAs in the development of parasites, host-parasite interaction, immune evasion and their abilities to govern infection in hosts. MiRNAs present in helminth parasites have been summarized in the current systematic review (SR). Electronic databases, including PubMed, Scopus, ProQuest, Embase, and Google Scholar search engine, were searched to identify helminth miRNA studies published from February 1993 till December 2019. Only the published articles in English were included in the study. A total of 1769 articles were preliminarily recorded. Following the strict inclusion and exclusion criteria, 105 studies were included in this SR. Most of these studies focused on the identification of miRNAs in helminth parasites and/or probing of differentially expressed host miRNA profiles in specific relevant tissues, while 12 studies aimed to detect parasite-derived miRNAs in host circulating system and 15 studies characterized extracellular vesicles (EV)-derived miRNAs secreted by parasites. In the current SR, information regarding all miRNAs expressed in helminth parasites has been comprehensively provided and the utility of helminth parasitesderived miRNAs in diagnosis and control of parasitic infections has been discussed. Furthermore, functional studies on helminth-derived miRNAs have also been presented.

Sections du résumé

BACKGROUND
MicroRNAs (miRNAs) are about 22-nucleotide, small, noncoding RNAs that control gene expression post-transcriptionally. Helminth parasites usually express a unique repertoire of genes, including miRNAs, across different developmental stages with subtle regulatory mechanisms.
OBJECTIVE
There is a necessity to investigate the involvement of miRNAs in the development of parasites, host-parasite interaction, immune evasion and their abilities to govern infection in hosts. MiRNAs present in helminth parasites have been summarized in the current systematic review (SR).
METHODS
Electronic databases, including PubMed, Scopus, ProQuest, Embase, and Google Scholar search engine, were searched to identify helminth miRNA studies published from February 1993 till December 2019. Only the published articles in English were included in the study.
RESULTS
A total of 1769 articles were preliminarily recorded. Following the strict inclusion and exclusion criteria, 105 studies were included in this SR. Most of these studies focused on the identification of miRNAs in helminth parasites and/or probing of differentially expressed host miRNA profiles in specific relevant tissues, while 12 studies aimed to detect parasite-derived miRNAs in host circulating system and 15 studies characterized extracellular vesicles (EV)-derived miRNAs secreted by parasites.
CONCLUSION
In the current SR, information regarding all miRNAs expressed in helminth parasites has been comprehensively provided and the utility of helminth parasitesderived miRNAs in diagnosis and control of parasitic infections has been discussed. Furthermore, functional studies on helminth-derived miRNAs have also been presented.

Identifiants

DOI: 10.2174/1566524021666211108114009 PMID: 34749620
pubmed: 34749620
pii: CMM-EPUB-118751
doi: 10.2174/1566524021666211108114009
doi:

Substances chimiques

MicroRNAs 0
RNA, Helminth 0

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

779-808

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Zahra Alizadeh (Z)

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Mahmoud Mahami-Oskouei (M)

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Adel Spotin (A)

Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Ehsan Ahmadpour (E)

Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Pengfei Cai (P)

Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.

Siamak Sandoghchian Shotorbani (S)

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Fariba Pashazadeh (F)

Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Iranian EMB Centre: A Joanna Briggs Institute Affiliated Group, Iran.

Fereshteh Ansari (F)

Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Iranian EMB Centre: A Joanna Briggs Institute Affiliated Group, Iran.

Hamed Mohammadi (H)

Non-Communicable Diseases Research Center, Alborz University of Medical Science, Karaj, Iran.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › MicroRNAs in Helminth Parasites: A Systematic Review.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › MicroRNAs in Helminth Parasites: A Systematic Review.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › MicroRNAs in Helminth Parasites: A Systematic Review.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Parasites › MicroRNAs in Helminth Parasites: A Systematic Review.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN des helminthes › MicroRNAs in Helminth Parasites: A Systematic Review.