Prevalence of sudden cardiac death in dogs with atrial fibrillation.
Holter analysis
cardiology
echocardiography
ventricular arrhythmia
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
12
10
2021
received:
22
01
2021
accepted:
13
10
2021
pubmed:
10
11
2021
medline:
24
12
2021
entrez:
9
11
2021
Statut:
ppublish
Résumé
Atrial fibrillation (AF) is associated with increased risk of sudden cardiac death (SCD) in humans, independent of secondary risk factors such as thrombogenic disorders. In dogs, SCD is described in a number of heart diseases, but an association between AF and SCD is unreported. (a) A higher proportion of dogs with AF will experience SCD, and (b) SCD will be associated with complex ventricular arrhythmias. One-hundred forty-two dogs with AF, and 127 dogs without AF. Retrospective, multicenter, case-control study. Dogs included in the AF group were compared to a control group of dogs in sinus rhythm, matched for echocardiographic diagnosis. Descriptive statistics were used to identify proportions of each group suffering SCD, compared using chi-squared testing. Risk factors for SCD in dogs with AF were evaluated at the univariable and multivariable level using binary logistic regression. Significance was P < .05. A significantly higher proportion of dogs with AF suffered SCD than dogs in the control group (14.8% vs 5.5%; P = .01). Younger age at diagnosis, larger left atrial size, and a history of syncope all were independent predictors of SCD in dogs with AF (χ Atrial fibrillation was associated with a higher prevalence of SCD in dogs. A history of syncope may be a useful predictor of SCD risk.
Sections du résumé
BACKGROUND
BACKGROUND
Atrial fibrillation (AF) is associated with increased risk of sudden cardiac death (SCD) in humans, independent of secondary risk factors such as thrombogenic disorders. In dogs, SCD is described in a number of heart diseases, but an association between AF and SCD is unreported.
HYPOTHESIS
OBJECTIVE
(a) A higher proportion of dogs with AF will experience SCD, and (b) SCD will be associated with complex ventricular arrhythmias.
ANIMALS
METHODS
One-hundred forty-two dogs with AF, and 127 dogs without AF.
METHODS
METHODS
Retrospective, multicenter, case-control study. Dogs included in the AF group were compared to a control group of dogs in sinus rhythm, matched for echocardiographic diagnosis. Descriptive statistics were used to identify proportions of each group suffering SCD, compared using chi-squared testing. Risk factors for SCD in dogs with AF were evaluated at the univariable and multivariable level using binary logistic regression. Significance was P < .05.
RESULTS
RESULTS
A significantly higher proportion of dogs with AF suffered SCD than dogs in the control group (14.8% vs 5.5%; P = .01). Younger age at diagnosis, larger left atrial size, and a history of syncope all were independent predictors of SCD in dogs with AF (χ
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Atrial fibrillation was associated with a higher prevalence of SCD in dogs. A history of syncope may be a useful predictor of SCD risk.
Identifiants
pubmed: 34750853
doi: 10.1111/jvim.16297
pmc: PMC8692199
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2588-2595Subventions
Organisme : The Langford Trust
Informations de copyright
© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Références
Vet J. 2020 Sep;263:105523
pubmed: 32928492
Am J Cardiol. 2019 Jan 1;123(1):69-74
pubmed: 30539748
Cochrane Database Syst Rev. 2019 Sep 04;9:CD005049
pubmed: 31483500
Circulation. 1998 Sep 8;98(10):946-52
pubmed: 9737513
Lancet. 2009 Jan 10;373(9658):155-66
pubmed: 19135613
Circulation. 2013 Nov 12;128(20):2192-201
pubmed: 24016454
J Vet Intern Med. 2008 Jan-Feb;22(1):114-9
pubmed: 18289297
J Vet Cardiol. 2021 Dec;38:18-30
pubmed: 34710652
J Vet Intern Med. 2021 Nov;35(6):2588-2595
pubmed: 34750853
J Vet Cardiol. 2015 Dec;17 Suppl 1:S318-28
pubmed: 26776589
J Am Heart Assoc. 2016 Jul 08;5(7):
pubmed: 27402235
J Vet Cardiol. 2017 Oct;19(5):455-461
pubmed: 28939249
J Vet Cardiol. 2019 Aug;24:48-57
pubmed: 31405554
J Vet Cardiol. 2005 Nov;7(2):75-83
pubmed: 19083323
Circ Arrhythm Electrophysiol. 2015 Feb;8(1):49-58
pubmed: 25414270
Nat Rev Cardiol. 2016 Jan;13(1):36-47
pubmed: 26194552
J Vet Cardiol. 2015 Dec;17 Suppl 1:S329-40
pubmed: 26776590
Stroke. 2016 Mar;47(3):895-900
pubmed: 26786114
BMJ. 2016 Sep 06;354:i4482
pubmed: 27599725
J Vet Intern Med. 2016 Jan-Feb;30(1):51-7
pubmed: 26681398
J Vet Intern Med. 2016 Mar-Apr;30(2):553-9
pubmed: 26936799
J Am Coll Cardiol. 2002 Jul 17;40(2):335-40
pubmed: 12106941
Rev Esp Cardiol. 2006 Dec;59(12):1328
pubmed: 17194428
Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1033-9
pubmed: 25236735
J Vet Intern Med. 2018 Jan;32(1):86-92
pubmed: 29205499
J Vet Intern Med. 2009 May-Jun;23(3):499-508
pubmed: 19645836
Am Heart J. 2004 May;147(5):837-40
pubmed: 15131539
J Vet Intern Med. 2020 Sep;34(5):1787-1793
pubmed: 32767718
J Vet Cardiol. 2005 Nov;7(2):121-9
pubmed: 19083327
J Vet Cardiol. 2005 Nov;7(2):85-96
pubmed: 19083324
Vet J. 2020 Oct;264:105535
pubmed: 33012438
Am J Ther. 2004 Jan-Feb;11(1):33-43
pubmed: 14704594
Circ Res. 2020 Jul 3;127(2):301-309
pubmed: 32833581
Circulation. 2003 Apr 29;107(16):2096-101
pubmed: 12695299
J Am Coll Cardiol. 1992 Sep;20(3):527-32
pubmed: 1512329
J Vet Intern Med. 2020 Nov;34(6):2223-2231
pubmed: 33031593
Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H725-31
pubmed: 23812387