Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer's Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside.

Maccioni RB, González A, Andrade V, Cortés N, Tapia JP, Guzmán-Martínez L (2018) Alzheimer s disease in the perspective of neuroimmunology. Open Neurol J 12:50

pubmed: 30069256 pmcid: 6040210

Tang Y, Lutz MW, Xing Y (2019) A systems-based model of Alzheimer’s disease. Alzheimers Dement 15(1):168–171

pubmed: 30102884

Zilberzwige-Tal S, Gazit E (2018) Go with the flow—microfluidics approaches for amyloid research. Chem Asian J 13(22):3437–3447

pubmed: 30117682

Gomez-Ramos A, Podlesniy P, Soriano E, Avila J (2015) Distinct X-chromosome SNVs from some sporadic AD samples. Sci Rep 5(1):1–11

Nacmias B, Piaceri I, Bagnoli S, Tedde A, Piacentini S, Sorbi S (2014) Genetics of Alzheimer’s disease and frontotemporal dementia. Curr Mol Med 14(8):993–1000

pubmed: 25323872

Katzman R (1986) Alzheimer’s disease. N Engl J Med 314(15):964–973

pubmed: 2870433

Smith MA (1998) Alzheimer disease. Int Rev Neurobiol 42:1–54

pubmed: 9476170

Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci 82(12):4245–4249

pubmed: 3159021 pmcid: 397973

Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM (1986) Microtubule associated protein tau A component of Alzheimer paired helical filaments. J Biol Chem 261(13):6084–6089

pubmed: 3084478

Tamagno E, Parola M, Bardini P, Piccini A, Borghi R, Guglielmotto M, ... Tabaton M (2005) β‐siteAPP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways. J Neurochem 92(3): 628-636

Sáez-Orellana F, Godoy PA, Bastidas CY, Silva-Grecchi T, Guzmán L, Aguayo LG, Fuentealba J (2016) ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of β-amyloid peptide in hippocampal neurons. Neuropharmacology 100:116–123

pubmed: 25896766

Godyń J, Jończyk J, Panek D, Malawska B (2016) Therapeutic strategies for Alzheimer’s disease in clinical trials. Pharmacological Reports: PR 68(1):127–138

pubmed: 26721364

Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol Sci 12:383–388

pubmed: 1763432

Lee VMY, Trojanowski JQ (1992) The disordered neuronal cytoskeleton in Alzheimer’s disease. Curr Opin Neurobiol 2(5):653–656

pubmed: 1422122

Clark CM, Xie S, Chittams J, Ewbank D, Peskind E, Galasko D, ... Trojanowski JQ (2003) Cerebrospinal fluid tau and β-amyloid: How well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Arch Neurol 60(12): 1696-1702

Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT (2011) Are tangles as toxic as they look? J Mol Neurosci 45(3):438–444

pubmed: 21638071 pmcid: 3173560

Davis DR, Anderton BH, Brion J-P, Reynolds CH, Hanger DP (1997) Oxidative stress induces dephosphorylation of τ in rat brain primary neuronal cultures. J Neurochem 68(4):1590–1597

pubmed: 9084430

Galas MC, Dourlen P, Bégard S, Ando K, Blum D, Hamdane M, Buée L (2006) The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons: implication in a pathological mechanism related to Alzheimer disease. J Biol Chem 281(28):19296–19304

pubmed: 16675464

Zambrano CA, Egaña JT, Núñez MT, Maccioni RB, González-Billault C (2004) Oxidative stress promotes τ dephosphorylation in neuronal cells: the roles of cdk5 and PP1. Free Radical Biol Med 36(11):1393–1402

De Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, ... Davies P (2006) Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging, 27(3), 394-401

Fagan AM, Holtzman DM (2010) Cerebrospinal fluid biomarkers of Alzheimer’s disease. Biomark Med 4(1):51–63

pubmed: 20361010

Garcia ML, Cleveland DW (2001) Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Curr Opin Cell Biol 13(1):41–48

pubmed: 11163132

Gómez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer’s disease. Ann Neurol 41(1):17–24

pubmed: 9005861

Ranjan B, Chong KH, Zheng J (2018) Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease. BMC Syst Biol 12(1):10

pubmed: 29671396 pmcid: 5907315

Yang L, Wang Z, Wang B, Justice NJ, Zheng H (2009) Amyloid precursor protein regulates Cav1. 2 L-type calcium channel levels and function to influence GABAergic short-term plasticity. J Neurosci 29(50):15660–15668

pubmed: 20016080 pmcid: 2833283

Wang YY, Zheng W, Ng CH, Ungvari GS, Wei W, Xiang YT (2017) Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer’s disease. Int J Geriatr Psychiatry 32(1):50–57

pubmed: 27645169

Wang Y, Shi Y, Wei H (2017) Calcium dysregulation in Alzheimer’s disease: a target for new drug development. Journal of Alzheimer’s Disease & Parkinsonism 7(5)

Sciacca MF, Monaco I, La Rosa C, Milardi D (2018) The active role of Ca2+ ions in Aβ-mediated membrane damage. Chem Commun 54(29):3629–3631

Goldstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR (2000) The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol 2(3):156–162

pubmed: 10707086

Samad N, Ishaq S, Bano S, Manzoor N (2017) Calcium regulation in Alzheimer’s disease: mechanistic understanding. J Coll Physicians Surg Pak 27(9):566–571

pubmed: 29017674

Santos RX, Correia SC, Wang X, Perry G, Smith MA, Moreira PI, Zhu X (2010) A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer’s disease. J Alzheimers Dis 20(s2):S401–S412

pubmed: 20463393 pmcid: 2923835

Mancuso M, Coppedè F, Murri L, Siciliano G (2007) Mitochondrial cascade hypothesis of Alzheimer’s disease: myth or reality? Antioxid Redox Signal 9(10):1631–1646

pubmed: 17887917

Cui K, Luo X, Xu K, Ven Murthy MR (2004) Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Prog Neuropsychopharmacol Biol Psychiatry 28(5):771–799

pubmed: 15363603

Teleanu RI, Chircov C, Grumezescu AM, Volceanov A, Teleanu DM (2019) Antioxidant therapies for neuroprotection-a review. J Clin Med 8(10):1659

pmcid: 6832623

Yokota A (1993) Relationship between polyunsaturated fatty acid (PUFA) and learning ability in the brain of rat fetus and newborn. Nihon Sanka Fujinka Gakkai Zasshi 45(1):15–22

pubmed: 8436838

Yamamoto N, Okaniwa Y, Mori S, Nomura M, Okuyama H (1991) Effects of a high-linoleate and a high-α-linolenate diet on the learning ability of aged rats evidence against an autoxidation-related lipid peroxide theory of aging. J Gerontol 46(1):B17–B22

pubmed: 1670780

Pagani L, Eckert A (2011) Amyloid-Beta interaction with mitochondria. Int J Alzheimers Dis 2011

Sanei M, Saberi-Demneh A (2019) Effect of curcumin on memory impairment: A systematic review. Phytomedicine 52:98–106

pubmed: 30599917

Ono K, Hasegawa K, Naiki H, Yamada M (2004) Curcumin has potent anti-amyloidogenic effects for Alzheimer’s β-amyloid fibrils in vitro. J Neurosci Res 75(6):742–750

pubmed: 14994335

Reddy ACP, Lokesh BR (1992) Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem 111(1):117–124

pubmed: 1588934

Baum L, Lam CWK, Cheung SKK, Kwok T, Lui V, Tsoh J, ... Mok V (2008) Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol 28(1): 110-113

Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM (2012) Oral curcumin for Alzheimer’s disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimer’s Res Ther 4(5):43

Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA (2016) Omega-3 fatty acid status enhances the prevention of cognitive decline by B vitamins in mild cognitive impairment. Journal of Alzheimer’s Disease: JAD 50(2):547–557

pubmed: 26757190

Benfeito S, Oliveira C, Fernandes C, Cagide F, Teixeira J, Amorim R, ... Borges F (2019) Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction. Eur J Med Chem 167: 525-545

Grimm MO, Mett J, Hartmann T (2016) The impact of vitamin E and other fat-soluble vitamins on Alzheimer’s disease. Int J Mol Sci 17(11)

La Fata G, Weber P, Mohajeri MH (2014) Effects of vitamin E on cognitive performance during ageing and in Alzheimer’s disease. Nutrients 6:5453–5472

pubmed: 25460513 pmcid: 4276978

La Fata G, Weber P, Mohajeri MH (2014) Effects of vitamin E on cognitive performance during ageing and in Alzheimer’s disease. Nutrients 6(12):5453–5472

pubmed: 25460513 pmcid: 4276978

Mazzanti G, Di Giacomo S (2016) Curcumin and resveratrol in the management of cognitive disorders: what is the clinical evidence? Molecules 21(9):1243

pmcid: 6273006

Sawda C, Moussa C, Turner RS (2017) Resveratrol for Alzheimer’s disease. Ann N Y Acad Sci 1403(1):142–149

pubmed: 28815614 pmcid: 5664214

Beal MF (2005) Mitochondria take center stage in aging and neurodegeneration. Ann Neurol 58(4):495–505

pubmed: 16178023

Di Mauro S, Schon EA (2003) Mitochondrial respiratory-chain diseases. N Engl J Med 348(26):2656–2668

Koopman WJ, Distelmaier F, Smeitink JA, Willems PH (2013) OXPHOS mutations and neurodegeneration. EMBO J 32(1):9–29

pubmed: 23149385

Noji H, Yoshida M (2001) The rotary machine in the cell, ATP synthase. J Biol Chem 276(3):1665–1668

pubmed: 11080505

Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408(6809):239–247

pubmed: 11089981

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44–84

pubmed: 16978905

Zhu X, Perry G, Smith MA, Wang X (2013) Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease. J Alzheimers Dis 33(s1):S253–S262

pubmed: 22531428 pmcid: 4097015

Ávila F, Schmeda-Hirschmann G, Silva E (2017) The major chromophore arising from glucose degradation and oxidative stress occurrence during lens proteins glycation induced by glucose. Molecules (Basel, Switzerland) 23(1):6. https://doi.org/10.3390/molecules23010006

doi: 10.3390/molecules23010006

Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120(4):483–495

pubmed: 15734681

Van Houten B, Woshner V, Santos JH (2006) Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair 5(2):145–152

pubmed: 15878696

Crouch PJ, Harding SME, White AR, Camakaris J, Bush AI, Masters CL (2008) Mechanisms of Aβ mediated neurodegeneration in Alzheimer’s disease. Int J Biochem Cell Biol 40(2):181–198

pubmed: 17804276

Morris G, Walder K, Puri BK, Berk M, Maes M (2016) The deleterious effects of oxidative and nitrosative stress on palmitoylation, membrane lipid rafts and lipid-based cellular signalling: new drug targets in neuroimmune disorders. Mol Neurobiol 53(7):4638–4658

pubmed: 26310971

Boom A, Authelet M, Dedecker R, Frédérick C, Van Heurck R, Daubie V, ... Brion JP (2009) Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells. Biochim Biophys Acta Mol Cell Res 1793(6), 1058–1067

Sayre LM, Perry G, Atwood CS, Smith MA (2000) The role of metals in neurodegenerative diseases. Cell Mol Biol (Noisy-le-Grand) 46(4):731–741

Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, Smith MA (2000) In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer’s disease: a central role for bound transition metals. J Neurochem 74(1):270–279

pubmed: 10617129

Mondragón-Rodríguez S, Perry G, Zhu X, Moreira PI, Acevedo-Aquino MC, Williams S (2013) Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer’s disease. Oxidative Medicine and Cellular Longevity, 2013

De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL (2007) Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem 282(15):11590–11601

pubmed: 17308309

Ferreira ST, Vieira MN, De Felice FG (2007) Soluble protein oligomers as emerging toxins in Alzheimer’s and other amyloid diseases. Int Union Biochem Mol Biol Life 59(4–5):332–345

Mattson MP, Chan SL (2003) Neuronal and glial calcium signaling in Alzheimer’s disease. Cell Calcium 34(4–5):385–397

pubmed: 12909083

Rai S, Kamat PK, Nath C, Shukla R (2013) A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. J Neuroimmunol 254(1–2):1–9

pubmed: 23021418

Kelly BL, Ferreira A (2006) β-amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons. J Biol Chem 281(38):28079–28089

pubmed: 16864575

Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ (2011) Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci 31(18):6627–6638

pubmed: 21543591 pmcid: 3100898

Briston T, Roberts M, Lewis S, Powney B, Staddon JM, Szabadkai G, Duchen MR (2017) Mitochondrial permeability transition pore: Sensitivity to opening and mechanistic dependence on substrate availability. Sci Rep 7(1):1–13

Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ (2000) Reactive oxygen species (Ros-Induced) Ros release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 192(7):1001–1014

pubmed: 11015441 pmcid: 2193314

Ichas F, Jouaville LS, Mazat JP (1997) Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89(7):1145–1153

pubmed: 9215636

Petronilli V, Miotto G, Canton M, Brini M, Colonna R, Bernardi P, Di Lisa F (1999) Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 76(2):725–734

pubmed: 9929477 pmcid: 1300077

Duchen MR (2000) Mitochondria and Ca

pubmed: 11115373

Gerschman R, Gilbert DL, Nye SW, Dwyer P, Fenn WO (1954) Oxygen poisoning and x-irradiation: a mechanism in common. Science 119(3097):623–626

pubmed: 13156638

Harman E (1956) Protein oxidation in aging and age-related diseases. Gerontology 11:298–300

Mattson MP, Lovell MA, Furukawa K, Markesbery WR (1995) Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem 65(4):1740–1751

pubmed: 7561872

Münch G, Lüth HJ, Wong A, Arendt T, Hirsch E, Ravid RA, Riederer P (2000) Crosslinking of α-synuclein by advanced glycation endproducts—an early pathophysiological step in Lewy body formation? J Chem Neuroanat 20(3–4):253–257

pubmed: 11207423

Floyd RA, Hensley K (2002) Oxidative stress in brain aging: implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23(5):795–807

pubmed: 12392783

Kirkinezos IG, Bacman SR, Hernandez D, Oca-Cossio J, Arias LJ, Perez-Pinzon MA, ... Moraes CT (2005) Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice. J Neurosci 25(1): 164-172

Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787–795

pubmed: 17051205

Mattiazzi M, D’Aurelio M, Gajewski CD, Martushova K, Kiaei M, Beal MF, Manfredi G (2002) Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J Biol Chem 277(33):29626–29633

pubmed: 12050154

Baloyannis SJ (2006) Mitochondrial alterations in Alzheimer’s disease. J Alzheimers Dis 9(2):119–126

pubmed: 16873959

Exner N, Lutz AK, Haass C, Winklhofer KF (2012) Mitochondrial dysfunction in Parkinson’s disease: Molecular mechanisms and pathophysiological consequences. EMBO J 31(14):3038–3062

pubmed: 22735187 pmcid: 3400019

Harman D (1972) The biologic clock: The mitochondria? J Am Geriatr Soc 20(4):145–147

pubmed: 5016631

Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, ... Shimohama S (2001) Mitochondrial abnormalities in Alzheimer’s disease. J Neurosci 21(9), 3017-3023

Schon EA, Przedborski S (2011) Mitochondria: the next (neurode) generation. Neuron 70(6):1033–1053

pubmed: 21689593 pmcid: 3407575

Christen Y (2000) Oxidative stress and Alzheimer disease. Am J Clin Nutr 71(2):621S-629S

pubmed: 10681270

Baloyannis SJ, Costa V, Michmizos D (2004) Mitochondrial alterations Alzheimer’s disease. Am J Alzheimers Dis Other Demen 19(2):89–93

pubmed: 15106389

García-Matas S, de Vera N, Aznar AO, Marimon JM, Adell A, Planas AM, ... Sanfeliu C (2010) In vitro and in vivo activation of astrocytes by amyloid-β is potentiated by pro-oxidant agents. J Alzheimers Dis 20(1), 229-245

Ichimura H, Parthasarathi K, Quadri S, Issekutz AC, Bhattacharya J (2003) Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries. J Clin Investig 111(5):691–699

pubmed: 12618523 pmcid: 151903

Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, ... Goldstein LS (2009) Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis 36(1), 11–25

Szabados T, Dul C, Majtényi K, Hargitai J, Pénzes Z, Urbanics R (2004) A chronic Alzheimer’s model evoked by mitochondrial poison sodium azide for pharmacological investigations. Behav Brain Res 154(1):31–40

pubmed: 15302108

Xiong K, Cai H, Luo XG, Struble RG, Clough RW, Yan XX (2007) Mitochondrial respiratory inhibition and oxidative stress elevate β-secretase (BACE1) proteins and activity in vivo in the rat retina. Exp Brain Res 181(3):435–446

pubmed: 17429617

Wahlster L, Arimon M, Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O (2013) Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease. Acta Neuropathol 125(2):187–199

pubmed: 23138650

Ito S, Ohtsuki S, Kamiie J, Nezu Y, Terasaki T (2007) Cerebral clearance of human amyloid-β peptide (1–40) across the blood–brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes. J Neurochem 103(6):2482–2490

pubmed: 17908238

Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, ... Zlokovic BV (2007). Clearance of amyloid-β by circulating lipoprotein receptors. Nat Med, 13(9): 1029-1031

Owen JB, Sultana R, Aluise CD, Erickson MA, Price TO, Bu G, …& Butterfield, D. A. (2010) Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. Free Radical Biol Med 49(11):1798–1803

Jeynes B, Provias J (2008) Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis. Curr Alzheimer Res 5(5):432–437

pubmed: 18855584

Bozyczko-Coyne D, O’Kane TM, Wu ZL, Dobrzanski P, Murthy S, Vaught JL, Scott RW (2001) CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ-induced cortical neuron apoptosis. J Neurochem 77(3):849–863

pubmed: 11331414

Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, ... Greenberg ME (2001) β-Amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci 21(19), 7551-7560

Wei W, Wang X, Kusiak JW (2002) Signaling events in amyloid β-peptide-induced neuronal death and insulin-like growth factor I protection. J Biol Chem 277(20):17649–17656

pubmed: 11882652

Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, ... Perry G (2005) Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology and Medicine 38(6), 746-754

Violet M, Delattre L, Tardivel M, Sultan A, Chauderlier A, Caillierez R, ... Galas MC (2014) A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions. Front Cell Neurosci 8:84

Santa-María I, Hernández F, Martín CP, Avila J, Moreno FJ (2004) Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers. Biochemistry 43(10):2888–2897

pubmed: 15005624

Su JH, Deng G, Cotman CW (1997) Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer’s disease brain. Brain Res 774(1–2):193–199

pubmed: 9452208

Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, ... Smith MA (2001) Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60(8): 759-767

Ferreira IL, Ferreiro E, Schmidt J, Cardoso JM, Pereira CM, Carvalho AL, Oliveira CR, Rego AC (2015) Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release. Neurobiol Aging 36(2):680–692

pubmed: 25442114

Hermann D, Mezler M, Müller MK, Wicke K, Gross G, Draguhn A, ... Nimmrich V (2013) Synthetic Aβ oligomers (Aβ1–42 globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers. Eur J Pharmacol 702(1-3): 44-55

Ueda K, Shinohara S, Yagami T, Asakura K, Kawasaki K (1997) Amyloid β protein potentiates Ca2+ influx through L-type voltage-sensitive Ca

pubmed: 8978734

Woods NK, Padmanabhan J (2012) Neuronal calcium signaling and Alzheimer’s disease. Calcium signaling 1193–1217

Yagami T, Ueda K, Sakaeda T, Itoh N, Sakaguchi G, Okamura N, ... Fujimoto M (2004) Protective effects of a selective L-type voltage-sensitive calcium channel blocker, S-312-d, on neuronal cell death. Biochem Pharmacol 67(6), 1153-1165

Butterfield DA, Lange MLB, Sultana R (2010) Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer’s disease. Biochim Biophys Acta Mol Cell Biol L 1801(8):924–929

Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X (2014) Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease. Biochim Biophys Acta Mol Basis Dis 1842(8):1240–1247

Butterfield DA, Lauderback CM (2002) Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress. Free Radical Biol Med 32(11):1050–1060

Butterfield DA (2014) The 2013 SFRBM discovery award: selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment. Free Radical Biol Med 74:157–174

Butterfield DA, Di Domenico F (1842) Barone E (2014) Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain. Biochim Biophys Acta Mol Basis Dis 9:1693–1706

Hensley K, Hall N, Subramaniam R, Cole P, Harris M, Aksenov M, ... Butterfield DA (1995) Brain regional correspondence between Alzheimer’s disease histopathology and biomarkers of protein oxidation. J Neurochem 65(5): 2146-2156

Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P (2015) High membrane protein oxidation in the human cerebral cortex. Redox Biol 4:200–207

pubmed: 25600696

Gow AJ, Duran D, Malcolm S, Ischiropoulos H (1996) Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation. FEBS Lett 385(1–2):63–66

pubmed: 8641468

Markesbery WR, Lovell MA (1998) Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer’s disease. Neurobiol Aging 19(1):33–36

pubmed: 9562500

Hardas SS, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA (2013) Oxidative modification of lipoic acid by HNE in Alzheimer disease brain. Redox Biol 1(1):80–85

pubmed: 24024140 pmcid: 3757677

Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer’s disease. J Neurochem 68(5):2092–2097

pubmed: 9109537

Gabbita SP, Lovell MA, Markesbery WR (1998) Increased nuclear DNA oxidation in the brain in Alzheimer’s disease. J Neurochem 71(5):2034–2040

pubmed: 9798928

Mecocci P, MacGarvey U, Beal MF (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease. Ann Neurol 36(5):747–751

pubmed: 7979220

Lovell MA, Soman S, Bradley MA (2011) Oxidatively modified nucleic acids in preclinical Alzheimer’s disease (PCAD) brain. Mech Ageing Dev 132(8–9):443–448

pubmed: 21878349 pmcid: 3188850

Coppedè F, Migliore L (2015) DNA damage in neurodegenerative diseases. Mutat Res 776:84–97. https://doi.org/10.1016/j.mrfmmm.2014.11.010

doi: 10.1016/j.mrfmmm.2014.11.010 pubmed: 26255941

Shan X, Lin CLG (2006) Quantification of oxidized RNAs in Alzheimer’s disease. Neurobiol Aging 27(5):657–662

pubmed: 15979765

Tramutola A, Lanzillotta C, Perluigi M, Butterfield DA (2017) Oxidative stress, protein modification and Alzheimer disease. Brain Res Bull 133:88–96

pubmed: 27316747

Aluise CD, Robinson RA, Cai J, Pierce WM, Markesbery WR, Butterfield DA (2011) Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer’s disease: insights into memory loss in MCI. J Alzheimers Dis 23(2):257–269

pubmed: 20930294

Reed T, Perluigi M, Sultana R, Pierce WM, Klein JB, Turner DM, ... Butterfield DA (2008) Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer’s disease. Neurobiol Dis 30(1):107-120

Schagger H, Ohm TG (1995) Human diseases with defects in oxidative phosphorylation: 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide gel electrophoresis. Eur J Biochem 227(3):916–921

pubmed: 7867655

Terni B, Boada J, Portero-Otin M, Pamplona R, Ferrer I (2010) Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer’s disease pathology. Brain Pathol 20(1):222–233

pubmed: 19298596

Cha MY, Cho HJ, Kim C, Jung YO, Kang MJ, Murray ME, ... Mook-Jung I (2015) Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer’s disease. Hum Mol Genet 24(22): 6492-6504

Chen Z, Zhong C (2013) Decoding Alzheimer’s disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies. Prog Neurobiol 108:21–43

pubmed: 23850509

Lauderback CM, Kanski J, Hackett JM, Maeda N, Kindy MS, Butterfield DA (2002) Apolipoprotein E modulates Alzheimer’s Aβ (1–42)-induced oxidative damage to synaptosomes in an allele-specific manner. Brain Res 924(1):90–97

pubmed: 11743999

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, ... Zlokovic BV (2008) apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain. J Clin Investig 118(12): 4002-4013

Ma J, Yee A, Brewer HB, Das S, Potter H (1994) Amyloid-associated proteins α 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 372(6501):92–94

pubmed: 7969426

Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y (2005) Lipid-and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Natl Acad Sci 102(51):18694–18699

pubmed: 16344479 pmcid: 1311737

Veinbergs I, Everson A, Sagara Y, Masliah E (2002) Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J Neurosci Res 67(3):379–387

pubmed: 11813243

Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang JIPING, Zhang JH (2010) Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience 169(1):402–414

pubmed: 20423721

Chen Y, Durakoglugil MS, Xian X, Herz J (2010) ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci 107(26):12011–12016

pubmed: 20547867 pmcid: 2900641

Hamanaka H, Katoh-Fukui Y, Suzuki K, Kobayashi M, Suzuki R, Motegi Y, …& Fujita, S. C. (2000) Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. Hum Mol Genet 9(3):353–361

pubmed: 10655544

Di Domenico F, Pupo G, Giraldo E, Badìa MC, Monllor P, Lloret A, ... Perluigi M (2016) Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients. Free Radic Biol Med 91: 1-9

Kharrazi H, Vaisi-Raygani A, Rahimi Z, Tavilani H, Aminian M, Pourmotabbed T (2008) Association between enzymatic and non-enzymatic antioxidant defense mechanism with apolipoprotein E genotypes in Alzheimer disease. Clin Biochem 41(12):932–936

pubmed: 18505684

Ramassamy C, Krzywkowski P, Averill D, Lussier-Cacan S, Theroux L, Christen Y, ... Poirier J (2001) Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain. Mol Brain Res 86(1-2): 76-83

Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Sahara N, …& Shoji, S. (2000) Apolipoprotein E allele–dependent antioxidant activity in brains with Alzheimer’s disease. Neurology 54(12):2319–2321

pubmed: 10881261

Mirza A, King A, Troakes C, Exley C (2017) Aluminium in brain tissue in familial Alzheimer’s disease. J Trace Elem Med Biol 40:30–36

pubmed: 28159219

Mustafa Rizvi SH, Parveen A, Verma AK, Ahmad I, Arshad M, Mahdi AA (2014) Aluminium induced endoplasmic reticulum stress mediated cell death in SH-SY5Y neuroblastoma cell line is independent of p53. PloS One 9(5):e98409

pubmed: 24878590 pmcid: 4039480

Al-Olayan EM, El-Khadragy MF, Abdel Moneim AE (2015) The protective properties of melatonin against aluminium-induced neuronal injury. Int J Exp Pathol 96(3):196–202

pubmed: 25891353 pmcid: 4545431

Hosseini-Sharifabad A, Rabbani M, Seyed-Yousefi Y, Safavi M (2020) Magnesium increases the protective effect of citicoline on aluminum chloride-induced cognitive impairment. Clin Psychopharmacol Neurosci 18(2):241–248

pubmed: 32329305 pmcid: 7242111

Prema A, Thenmozhi AJ, Manivasagam T, Essa MM, Akbar MD, Akbar M (2016) Fenugreek seed powder nullified aluminium chloride induced memory loss, biochemical changes, Aβ burden and apoptosis via regulating Akt/GSK3β signaling pathway. PloS One 11(11):e0165955

pubmed: 27893738 pmcid: 5125597

Moreira-Silva D, Vizin R, Martins T, Ferreira TL, Almeida MC, Carrettiero DC (2019) Intracerebral injection of streptozotocin to model Alzheimer disease in rats. Bio-protocol 9(20):e3397

pubmed: 33654898 pmcid: 7853929

Alluri R, Ambati SR, Routhu K, Kopalli SR, Koppula S (2020) Phosphoinositide 3-kinase inhibitor AS605240 ameliorates streptozotocin-induced Alzheimer’s disease like sporadic dementia in experimental rats. EXCLI J 19:71–85

pubmed: 32038117 pmcid: 7003642

Kamat PK (2015) Streptozotocin induced Alzheimer’s disease like changes and the underlying neural degeneration and regeneration mechanism. Neural Regen Res 10(7):1050–1052

pubmed: 26330820 pmcid: 4541228

Retinasamy T, Shaikh MF, Kumari Y, Abidin S, Othman I (2020) Orthosiphon stamineus standardized extract reverses streptozotocin-induced Alzheimer’s disease-like condition in a rat model. Biomedicines 8(5):104

pmcid: 7277846

Correia SC, Santos RX, Santos MS, Casadesus G, Lamanna JC, Perry G, Smith MA, Moreira PI (2013) Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer’s disease. Curr Alzheimer Res 10(4):406–419

pubmed: 23061885

Ward RJ, Zucca FA, Duyn JH, Crichton RR, Zecca L (2014) The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol 13(10):1045–1060

pubmed: 25231526 pmcid: 5672917

Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, ... Perry G (2004) Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J Alzheimers Dis 6(2): 165-169

Castellani RJ, Moreira PI, Perry G, Zhu X (2012) The role of iron as a mediator of oxidative stress in Alzheimer disease. BioFactors 38:133–138

pubmed: 22447715

Lipinski B, Sajdel-Sulkowska EM (2006) New insight into Alzheimer disease: demonstration of fibrin (ogen)-serum albumin insoluble deposits in brain tissue. Alzheimer Dis Assoc Disord 20(4):323–326

pubmed: 17132984

Lipinski B, Pretorius E (2012) Novel pathway of iron-induced blood coagulation: implications for diabetes mellitus and its complications. Polskie Archiwum Medycyny Wewnetrznej 122(3):115–122

pubmed: 22460041

Cao JY, Dixon SJ (2016) Mechanisms of ferroptosis. Cell Mol Life Sci 73(11):2195–2209

pubmed: 27048822 pmcid: 4887533

Fanzani A, Poli M (2017) Iron, oxidative damage and ferroptosis in rhabdomyosarcoma. Int J Mol Sci 18(8):1718

pmcid: 5578108

Masaldan S, Bush AI, Devos D, Rolland AS, Moreau C (2019) Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration. Free Radical Biol Med 133:221–233

Nikseresht S, Bush AI, Ayton S (2019) Treating Alzheimer’s disease by targeting iron. Br J Pharmacol 176(18):3622–3635

pubmed: 30632143 pmcid: 6715619

Weiland A, Wang Y, Wu W, Lan X, Han X, Li Q, Wang J (2019) Ferroptosis and its role in diverse brain diseases. Mol Neurobiol 56(7):4880–4893

pubmed: 30406908

Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI (2004) Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer’s Aβ peptides. J Biol Inorg Chem 9(8):954–960

pubmed: 15578276

Liu B, Moloney A, Meehan S, Morris K, Thomas SE, Serpell LC, …& Crowther, D. C. (2011) Iron promotes the toxicity of amyloid β peptide by impeding its ordered aggregation. J Biol Chem 286(6):4248–4256

pubmed: 21147772

Mantyh PW, Ghilardi JR, Rogers S, DeMaster E, Allen CJ, Stimson ER, Maggio JE (1993) Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide. J Neurochem 61:1171–1174

pubmed: 8360682

Schubert D, Chevion M (1995) The role of iron in beta amyloid toxicity. Biochem Biophys Res Commun 216(2):702–707

pubmed: 7488167

Everett J, Collingwood JF, Tjendana-Tjhin V, Brooks J, Lermyte F, Plascencia-Villa G, ... Telling ND (2018) Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer’s disease subjects. Nanoscale 10(25), 11782-11796

Liu JL, Fan YG, Yang ZS, Wang ZY, Guo C (2018) Iron and Alzheimer’s disease: from pathogenesis to therapeutic implications. Front Neurosci 12:632

pubmed: 30250423 pmcid: 6139360

Derry PJ, Hegde ML, Jackson GR, Kayed R, Tour JM, Tsai AL, Kent TA (2020) Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective. Prog Neurobiol 184:101716

pubmed: 31604111

de Lima PDL, Yamada ES, da Costa ET, do O Pessoa C, Rabenhorst SHB, de Oliveira Bahia M, Cardoso PC, Santos RA, de Arruda Cardoso Smith M, Burbano RR (2005) Genotoxic effects of rotenone on cultured lymphocytes. Genetics and Molecular Research : GMR 4(4):822–831

pubmed: 16475130

Niedzielska E, Smaga I, Gawlik M, Moniczewski A, Stankowicz P, Pera J, Filip M (2016) Oxidative stress in neurodegenerative diseases. Mol Neurobiol 53(6):4094–4125

pubmed: 26198567

Jiang T, Sun Q, Chen S (2016) Oxidative stress: a major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease. Prog Neurobiol 147:1–19

pubmed: 27769868

Pisoschi AM, Pop A (2015) The role of antioxidants in the chemistry of oxidative stress: a review. Eur J Med Chem 97:55–74

pubmed: 25942353

Poljsak B, Šuput D (2013) an, Milisav I (2013). ROS and antioxidants: Achieving the balance between when to use the synthetic antioxidants. Oxidative Medicine and Cellular Longevity, 956792

Al-Oud SS (2003) Heavy metal contents in tea and herb leaves. Pakistan Journal of Biological Sciences (Pakistan) 6:208–212

El-Sayed IH, Lotfy M, El-Khawaga OA, Nasif WA, El-Shahat M (2006) Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice. Toxicol Ind Health 22(4):157–163

pubmed: 16786837

Lopes GK, Schulman HM, Hermes-Lima M (1999) Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. Biochim Biophys Acta Gen Subj 1472(1–2):142–152

Leopoldini M, Russo N, Toscano M (2011) The molecular basis of working mechanism of natural polyphenolic antioxidants. Food Chem 125(2):288–306

Marković Z (2016) Study of the mechanisms of antioxidative action of different antioxidants. J Serb Soc Comput Mech 10(1):135–150

Golden TR, Patel M (2009) Catalytic antioxidants and neurodegeneration. Antioxid Redox Signal 11(3):555–570

pubmed: 18754709 pmcid: 2933572

Amato A, Terzo S, Mulè F (2019) Natural compounds as beneficial antioxidant agents in neurodegenerative disorders: a focus on Alzheimer’s disease. Antioxidants (Basel, Switzerland) 8(12):608. https://doi.org/10.3390/antiox8120608

doi: 10.3390/antiox8120608

Forman HJ, Zhang H, Rinna A (2009) Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med 30(1–2):1–12

pubmed: 18796312

Lu SC (2013) Glutathione synthesis. Biochim Biophys Acta Gen Subj 1830(5):3143–3153

Ansari MA, Scheff SW (2010) Oxidative stress in the progression of Alzheimer disease in the frontal cortex. J Neuropathol Exp Neurol 69(2):155–167

pubmed: 20084018

Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, …& Zilmer, M. (2001) The cerebrocortical areas in normal brain aging and in Alzheimer’s disease: noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochem Res 26(4):353–361

pubmed: 11495345

Mandal PK, Saharan S, Tripathi M, Murari G (2015) Brain glutathione levels–a novel biomarker for mild cognitive impairment and Alzheimer’s disease. Biol Psychiat 78(10):702–710

pubmed: 26003861

Docampo R, Moreno SNJ (2017) 17-biochemistry of trypanosoma cruzi. In: Telleria J, Tibayrenc M (eds) American Trypanosomiasis Chagas Disease, 2nd edn. Elsevier; London, p 371–400

Nabi S (2014) Endogenous antioxidants. In: Toxic effects of mercury. Springer, New Delhi, p 117–120

Undeland I (2016). Oxidative stability of seafood. In: Oxidative stability and shelf life of foods containing oils and fats (pp. 391–460). AOCS Press

Asakura H, Kitahora T (2018) Antioxidants and polyphenols in inflammatory bowel disease: ulcerative colitis and Crohn disease. In: Polyphenols: prevention and treatment of human disease (pp. 279–292). Academic Press

Homma T, Fujii J (2019) Chapter 5-oxidative stress and dysfunction of the intracellular proteolytic machinery: A pathological hallmark of nonalcoholic fatty liver disease. In: Watson RR, Preedy VR (eds) Dietary Interventions in Liver Disease. Academic Press, Boston, pp 59–70

Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C (2010) Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer’s disease. Neurosci Lett 469(1):6–10

pubmed: 19914330

Sultana R, Piroddi M, Galli F, Butterfield DA (2008) Protein levels and activity of some antioxidant enzymes in hippocampus of subjects with amnestic mild cognitive impairment. Neurochem Res 33(12):2540–2546

pubmed: 18320305

Thimraj TA, George L, Asrafuzzaman S, Upadhyay S, Ganguly K (2018) Chapter 7-oxidative signaling in chronic obstructive airway diseases. In: Chatterjee S, Jungraithmayr W, Bagchi D (eds) Immunity and Inflammation in Health and Disease. Academic Press, Boston, pp 79–98

Matés JM, Pérez-Gómez C, De Castro IN (1999) Antioxidant enzymes and human diseases. Clin Biochem 32(8):595–603

pubmed: 10638941

Sofic E, Salkovic-Petrisic M, Tahirovic I, Sapcanin A, Mandel S, Youdim M, Riederer P (2015) Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30. J Neural Transm 122(4):559–564

pubmed: 25252744

Gsell W, Conrad R, Hickethier M, Sofic E, Frölich L, Wichart I, Jellinger K, Moll G, Ransmayr G, Beckmann H (1995) Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type. J Neurochem 64(3):1216–1223

pubmed: 7861154

Behl C (1994) Davis JB, Lesley R, and Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817–827

pubmed: 8004671

Habib LK, Lee MT, Yang J (2010) Inhibitors of catalase-amyloid interactions protect cells from β-amyloid-induced oxidative stress and toxicity. J Biol Chem 285(50):38933–38943

pubmed: 20923778 pmcid: 2998107

Hane F, Tran G, Attwood SJ, Leonenko Z (2013) Cu 2+ affects amyloid-β (1–42) aggregation by increasing peptide-peptide binding forces. PloS One 8(3):e59005

pubmed: 23536847 pmcid: 3594192

Gabbita SP, Aksenov MY, Lovell MA, Markesbery WR (1999) Decrease in peptide methionine sulfoxide reductase in Alzheimer’s disease brain. J Neurochem 73(4):1660–1666

pubmed: 10501213

Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, ... Jordan-Sciutto KL (2007) Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol 66(1): 75-85

Chen K, Gunter K, Maines MD (2000) Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J Neurochem 75(1):304–313

pubmed: 10854275

Giordano G, White CC, Mohar I, Kavanagh TJ, Costa LG (2007) Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells. Toxicol Sci 100(2):433–444

pubmed: 17804861

Lim JH, Kim KM, Kim SW, Hwang O, Choi HJ (2008) Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage. Pharmacol Res 57(5):325–331

pubmed: 18455424

Satoh T, Okamoto SI, Cui J, Watanabe Y, Furuta K, Suzuki M, ... Lipton SA (2006) Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers. Proc Natl Acad Sci 103(3), 768-773

Tanito M, Agbaga MP, Anderson RE (2007) Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. Free Radical Biol Med 42(12):1838–1850

Ishii T, Itoh K, Ruiz E, Leake DS, Unoki H, Yamamoto M, Mann GE (2004) Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res 94(5):609–616

pubmed: 14752028

Saddawi-Konefka R, Seelige R, Gross ET, Levy E, Searles SC, Washington Jr A, ... Bui JD (2016) Nrf2 induces IL-17D to mediate tumor and virus surveillance. Cell Rep 16(9): 2348-2358

Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Can Res 62(18):5196–5203

Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, ... Yamamoto M (2016) Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun 7(1): 1-14

Quinti L, Naidu SD, Träger U, Chen X, Kegel-Gleason K, Llères D, ... Kazantsev AG (2017) KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients. Proc Natl Acad Sci 114(23): E4676-E4685

Zhao G, Yao-Yue C, Qin GW, Guo LH (2012) Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons. Neurobiol Aging 33(1):176–186

pubmed: 20382451

Dragicevic N, Smith A, Lin X, Yuan F, Copes N, Delic V, ... Bradshaw PC (2011) Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer’s amyloid-induced mitochondrial dysfunction. J Alzheimers Dis 26(3), 507-521

Zhu LN, Mei X, Zhang ZG, Xie YP, Lang F (2019) Curcumin intervention for cognitive function in different types of people: a systematic review and meta-analysis. Phytother Res 33(3):524–533

pubmed: 30575152

Thota RN, Rosato JI, Dias CB, Burrows TL, Martins RN, Garg ML (2020) Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3β and islet amyloid polypeptide in adults with high risk of type 2 diabetes and Alzheimer’s disease. Nutrients 12(4):1032

pmcid: 7230780

Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, ... Frautschy SA (2008) Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease. J Pharmacol Exp Ther 326(1), 196-208

Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, …& Cole, G. M. (2009) β-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci 29(28):9078–9089

pubmed: 19605645 pmcid: 3849615

Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG (2004) Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci 101(22):8491–8496

pubmed: 15152078 pmcid: 420421

Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, ... Frautschy SA (2005) Prevention of Alzheimer’s disease: omega-3 fatty acid and phenolic antioxidantinterventions. Neurobiol Aging 26(1): 133-136

Green P, Glozman S, Yavin E (2001) Ethyl docosahexaenoate-associated decrease in fetal brain lipid peroxide production is mediated by activation of prostanoid and nitric oxide pathways. Biochem Biophys Acta 1531(1–2):156–164

pubmed: 11278180

Yavin E, Brand A, Green P (2002) Docosahexaenoic acid abundance in the brain: a biodevice to combat oxidative stress. Nutr Neurosci 5(3):149–157

pubmed: 12041873

Hossain MS, Hashimoto M, Gamoh S, Masumura S (1999) Antioxidative effects of docosahexaenoic acid in the cerebrum versus cerebellum and brainstem of aged hypercholesterolemic rats. J Neurochem 72(3):1133–1138

pubmed: 10037485

Grimm MO, Kuchenbecker J, Grösgen S, Burg VK, Hundsdörfer B, Rothhaar TL, Friess P, de Wilde MC, Broersen LM, Penke B, Péter M, Vígh L, Grimm HS, Hartmann T (2011) Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms. J Biol Chem 286(16):14028–14039

pubmed: 21324907 pmcid: 3077603

Hashimoto M, Hossain S (2011) Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer’s disease. J Pharmacol Sci 116(2):150–162

pubmed: 21606627

Cole GM, Ma QL, Frautschy SA (2009) Omega-3 fatty acids and dementia. Prostaglandins Leukot Essent Fatty Acids 81(2–3):213–221

pubmed: 19523795 pmcid: 4019002

Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM (2007) Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci 27(16):4385–4395

pubmed: 17442823 pmcid: 6672302

Lim SY, Suzuki H (2000) Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. J Nutr 130(6):1629–1632

pubmed: 10827221

Minami M, Kimura S, Endo T, Hamaue N, Hirafuji M, Togashi H, …& Okuyama, H. (1997) Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. Pharmacol Biochem Behav 58(4):1123–1129

pubmed: 9408223

Külzow N, Witte AV, Kerti L, Grittner U, Schuchardt JP, Hahn A, Flöel A (2016) Impact of omega-3 fatty acid supplementation on memory functions in healthy older adults. J Alzheimers Dis 51(3):713–725

pubmed: 26890759

Freund-Levi Y, Eriksdotter-Jönhagen M, Cederholm T, Basun H, Faxén-Irving G, Garlind A, Vedin I, Vessby B, Wahlund LO, Palmblad J (2006) Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 63(10):1402–1408

pubmed: 17030655

Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, Wahlund LO, Schultzberg M, Basun H, Cederholm T, Palmblad J (2015) Plasma fatty acid profiles in relation to cognition and gender in Alzheimer’s disease patients during oral omega-3 fatty acid supplementation: the omega D study. J Alzheimers Dis 48(3):805–812

pubmed: 26402079

Shinto L, Quinn J, Montine T, Dodge HH, Woodward W, Baldauf-Wagner S, Waichunas D, Bumgarner L, Bourdette D, Silbert L, Kaye J (2014) A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer’s disease. J Alzheimers Dis 38(1):111–120

pubmed: 24077434

Irving GF, Freund-Levi Y, Eriksdotter-Jönhagen M, Basun H, Brismar K, Hjorth E, Palmblad J, Vessby B, Vedin I, Wahlund LO, Cederholm T (2009) Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer’s disease: the omega-3 Alzheimer’s disease study. J Am Geriatr Soc 57(1):11–17

pubmed: 19054188

Freund Levi Y, Vedin I, Cederholm T, Basun H, Faxén Irving G, Eriksdotter M, Hjorth E, Schultzberg M, Vessby B, Wahlund LO, Salem N Jr, Palmblad J (2014) Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer’s disease: the OmegAD study. J Intern Med 275(4):428–436

pubmed: 24410954

Hooijmans CR, Pasker-de Jong PC, de Vries RB, Ritskes-Hoitinga M (2012) The effects of long-term omega-3 fatty acid supplementation on cognition and Alzheimer’s pathology in animal models of Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis 28(1):191–209

pubmed: 22002791

Vedin I, Cederholm T, Freund-Levi Y, Basun H, Hjorth E, Irving GF, Eriksdotter-Jönhagen M, Schultzberg M, Wahlund LO, Palmblad J (2010) Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study. J Lipid Res 51(5):1179–1185

pubmed: 19965584 pmcid: 2853444

Phillips MA, Childs CE, Calder PC, Rogers PJ (2015) No effect of omega-3 fatty acid supplementation on cognition and mood in individuals with cognitive impairment and probable Alzheimer’s disease: a randomised controlled trial. Int J Mol Sci 16(10):24600–24613

pubmed: 26501267 pmcid: 4632767

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD (2015) Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr 102(1):215–221

pubmed: 25877495

Guan JZ, Guan W-P, Maeda T, Makino N (2011) Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer’s disease. Gerontology 58:62–69

pubmed: 21912072

Kaneai N, Arai M, Takatsu H, Fukui K, Urano S (2012) Vitamin E inhibits oxidative stress-induced denaturation of nerve terminal proteins involved in neurotransmission. J Alzheimers Dis 28(1):183–189

pubmed: 21971407

Wang X, Quinn PJ (1999) Vitamin E and its function in membranes. Prog Lipid Res 38(4):309–336

pubmed: 10793887

Dong S, Huang X, Zhen J, Van Halm-Lutterodt N, Wang J, Zhou C, Yuan L (2018) Dietary vitamin E status dictates oxidative stress outcomes by modulating effects of fish oil supplementation in Alzheimer disease model APP swe/PS1 dE9 mice. Mol Neurobiol 55(12):9204–9219

pubmed: 29656360

Li FJ, Shen L, Ji HF (2012) Dietary intakes of vitamin E, vitamin C, and β-carotene and risk of Alzheimer’s disease: a meta-analysis. J Alzheimers Dis 31(2):253–258

pubmed: 22543848

Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, Love S, Schellenberg GD, McCarten JR, Malphurs J, Prieto S, Chen P, Loreck DJ, Trapp G, Bakshi RS, Mintzer JE, Heidebrink JL, Vidal-Cardona A, Arroyo LM, Cruz AR, … Guarino PD (2014) Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA 311(1), 33–44

Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The Alzheimer’s Disease Cooperative Study. N Engl J Med 336(17):1216–1222

pubmed: 9110909

Lloret A, Badía MC, Mora NJ, Pallardó FV, Alonso MD, Viña J (2009) Vitamin E paradox in Alzheimer’s disease: it does not prevent loss of cognition and may even be detrimental. J Alzheimers Dis 17(1):143–149

pubmed: 19494439

McCleery J, Abraham RP, Denton DA, Rutjes AW, Chong LY, Al-Assaf AS, Griffith DJ, Rafeeq S, Yaman H, Malik MA, Di Nisio M, Martínez G, Vernooij RW, Tabet N (2018) Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment. Cochrane Database Syst Rev 11(11):CD011905

pubmed: 30383288

Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL, Alzheimer’s Disease Cooperative Study Group (2009) Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology 72(24):2115–2121

pubmed: 19528519 pmcid: 2697965

Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ, Alzheimer’s Disease Cooperative Study Group (2005) Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352(23):2379–2388

pubmed: 15829527

Thomas A, Iacono D, Bonanni L, D’Andreamatteo G, Onofrj M (2001) Donepezil, rivastigmine, and vitamin E in Alzheimer disease: a combined P300 event-related potentials/neuropsychologic evaluation over 6 months. Clin Neuropharmacol 24(1):31–42

pubmed: 11290880

Brigelius-Flohé R (2009) Vitamin E: the shrew waiting to be tamed. Free Radical Biol Med 46(5):543–554

Yatin SM, Varadarajan S, Butterfield DA (2000) Vitamin E prevents Alzheimer’s amyloid ß-Peptide (1–42)-induced neuronal protein oxidation and reactive oxygen species production. Journal of Alzheimer’s Disease 2(2):123–131

pubmed: 12214102

Devore EE, Grodstein F, van Rooij FJ, Hofman A, Stampfer MJ, Witteman JC, Breteler MM (2010) Dietary antioxidants and long-term risk of dementia. Arch Neurol 67(7):819–825

pubmed: 20625087 pmcid: 2923546

Giraldo E, Lloret A, Fuchsberger T, Viña J (2014) Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: protective role of vitamin E. Redox Biol 2:873–877

pubmed: 25061569 pmcid: 4099506

Montiel T, Quiroz-Baez R, Massieu L, Arias C (2006) Role of oxidative stress on β-amyloid neurotoxicity elicited during impairment of energy metabolism in the hippocampus: protection by antioxidants. Exp Neurol 200(2):496–508

pubmed: 16626708

Bittner DM (2009) Combination therapy of acetylcholinesterase inhibitor and vitamin E in Alzheimer disease. J Clin Psychopharmacol 29(5):511–513

pubmed: 19745661

Kim HS, Lee BM (2001) Protective effects of antioxidant supplementation on plasma lipid peroxidation in smokers. J Toxicol Environ Health A 63(8):583–598

pubmed: 11549118

Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, De Jager C, ... Smith AD (2008) Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology 71(11): 826-832.

Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT, Scherr PA (2005) Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr 81(2):508–514

pubmed: 15699242

Ahmed HH (2012) Modulatory effects of vitamin E, acetyl-l-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer’s disease in rat model. Exp Toxicol Pathol 64(6):549–556

pubmed: 21183322

Arlt S, Müller-Thomsen T, Beisiegel U, Kontush A (2012) Effect of one-year vitamin C-and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer’s disease. Neurochem Res 37(12):2706–2714

pubmed: 22878647

Pavlik VN, Doody RS, Rountree SD, Darby EJ (2009) Vitamin E use is associated with improved survival in an Alzheimer’s disease cohort. Dement Geriatr Cogn Disord 28(6):536–540

pubmed: 20016184 pmcid: 2866579

Rivière S, Birlouez-Aragon I, Nourhashémi F, Vellas B (1998) Low plasma vitamin C in Alzheimer patients despite an adequate diet. Int J Geriatr Psychiatry 13(11):749–754

pubmed: 9850871

Richardson JS (1993) Free radicals in the genesis of Alzheimer’s disease a. Ann N Y Acad Sci 695(1):73–76

pubmed: 8239316

Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, ... Relkin NR (2000) Intraneuronal Aβ42 accumulation in human brain. Am J Pathol 156(1): 15-20

Markesbery WR, Carney JM (1999) Oxidative alterations in Alzheimer’s disease. Brain Pathol 9(1):133–146

pubmed: 9989456

Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38(3):357–366

pubmed: 7668820

Connor JR, Menzies SL, St. Martin SM, Mufson EJ (1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer’s diseased brains. J Neurosci Res 31(1):75–83

pubmed: 1613823

Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) β-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380(6570):168–171

pubmed: 8600393

Quinn J, Suh J, Moore MM, Kaye J, Frei B (2003) Antioxidants in Alzheimer’s disease-vitamin C delivery to a demanding brain. J Alzheimers Dis 5(4):309–313

pubmed: 14624026

Frei B, Stocker R, Ames BN (1988) Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci 85(24):9748–9752

pubmed: 3200852 pmcid: 282858

Gale CR, Martyn CN, Cooper C (1996) Cognitive impairment and mortality in a cohort of elderly people. BMJ 312(7031):608–611

pubmed: 8595334 pmcid: 2350374

Lindeman RD, Romero LJ, Koehler KM, Liang HC, LaRue A, Baumgartner RN, Garry PJ (2000) Serum vitamin B12, C and folate concentrations in the New Mexico elder health survey: correlations with cognitive and affective functions. J Am Coll Nutr 19(1):68–76

pubmed: 10682878

Perrig WJ, Perrig P, Stähelin HB (1997) The relation between antioxidants and memory performance in the old and very old. J Am Geriatr Soc 45(6):718–724

pubmed: 9180666

Perkins AJ, Hendrie HC, Callahan CM, Gao S, Unverzagt FW, Xu Y, ... Hui SL (1999) Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey. Am J Epidemiol 150(1), 37-44

Schmidt R, Hayn M, Reinhart B, Roob G, Schmidt H, Schumacher M, ... Launer LJ (1998) Plasma antioxidants and cognitive performance in middle‐aged and older adults: results of the Austrian stroke prevention study. J Am Geriatr Soc 46(11):1407-1410

Whalley LJ, Fox HC, Lemmon HA, Duthie SJ, Collins AR, Peace H, ... Deary IJ (2003) Dietary supplement use in old age: associations with childhood IQ, current cognition and health. Int J Geriatr Psychiatry 18(9): 769-776

Rinaldi P, Polidori MC, Metastasio A, Mariani E, Mattioli P, Cherubini A, ... Mecocci P (2003) Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease. Neurobiol Aging 24(7): 915-919

Sato R, Helzlsouer KJ, Comstock GW, Hoffman SC (2006) A cross-sectional study of vitamin C and cognitive function in older adults: the differential effects of gender. J Nutr Health Aging 10(1):37

pubmed: 16453056

Rinaldi CA, Bucknall CA, Gill JS (2002) Beneficial effects of biventricular pacing in a patient with hypertrophic cardiomyopathy and intraventricular conduction delay. Heart (British Cardiac Society), 87(6), e6. https://doi.org/10.1136/heart.87.6.e6

Chandra S (2001) Studies of cell division (mitosis and cytokinesis) by dynamic secondary ion mass spectrometry ion microscopy: LLC-PK1 epithelial cells as a model for subcellular isotopic imaging. J Microsc 204(Pt 2):150–165. https://doi.org/10.1046/j.1365-2818.2001.00944.x

doi: 10.1046/j.1365-2818.2001.00944.x pubmed: 11737547

Travica N, Ried K, Sali A, Scholey A, Hudson I, Pipingas A (2017) Vitamin C status and cognitive function: a systematic review. Nutrients 9(9):960

pmcid: 5622720

Kontush A, Mann U, Arlt S, Ujeyl A, Lührs C, Müller-Thomsen T, Beisiegel U (2001) Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer’s disease. Free Radical Biol Med 31(3):345–354

Boothby LA, Doering PL (2005) Vitamin C and vitamin E for Alzheimer’s disease. Ann Pharmacother 39(12):2073–2080

pubmed: 16227450

Loef M, Schrauzer GN, Walach H (2011) Selenium and Alzheimer’s disease: a systematic review. J Alzheimers Dis 26(1):81–104

pubmed: 21593562

Pinton S, Brüning CA, Oliveira CES, Prigol M, Nogueira CW (2013) Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer’s type model in rats. J Nutr Biochem 24(1):311–317

pubmed: 22959057

Savarino L, Granchi D, Ciapetti G, Cenni E, Ravaglia G, Forti P, ... Mattioli R (2001) Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians. Exp Gerontol 36(2):327-339

Akbaraly TN, Hininger-Favier I, Carriere I, Arnaud J, Gourlet V, Roussel AM, Berr C (2007) Plasma selenium over time and cognitive decline in the elderly. Epidemiology 52–58

Cardoso BR, Ong TP, Jacob-Filho W, Jaluul O, Freitas MIDÁ, Cozzolino SMF (2010) Nutritional status of selenium in Alzheimer’s disease patients. Br J Nutr 103(6):803–806

pubmed: 19948078

Ishrat T, Parveen K, Khan MM, Khuwaja G, Khan MB, Yousuf S, ... Islam F (2009) Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type. Brain Res 1281L: 117-127

Song G, Zhang Z, Wen L, Chen C, Shi Q, Zhang Y, ... Liu Q (2014) Selenomethionine ameliorates cognitive decline, reduces tau hyperphosphorylation, and reverses synaptic deficit in the triple transgenic mouse model of Alzheimer’s disease. J Alzheimers Dis 41(1): 85-99

Tolonen M, Halme M, Sarna S (1985) Vitamin E and selenium supplementation in geriatric patients. Biol Trace Elem Res 7(3):161–168

pubmed: 24259118

Lovell MA, Xiong S, Lyubartseva G, Markesbery WR (2009) Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice. Free Radical Biol Med 46(11):1527–1533

Van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, Ittner LM (2010) Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer’s disease models. Proc Natl Acad Sci 107(31):13888–13893

pubmed: 20643941 pmcid: 2922247

Bucana CD, Nadakavukaren MJ, Frehn JL (1974) Novel features of hamster pinealocyte ultrastructure. Tissue Cell 6(1):85–93. https://doi.org/10.1016/0040-8166(74)90024-x

doi: 10.1016/0040-8166(74)90024-x pubmed: 4831830

Buendia I, Navarro E, Michalska P, Gameiro I, Egea J, Abril S, ... León R (2015) New melatonin–cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection. Future Med Chem 7(15): 1961-1969

Calvo J, Boya J (1984) Ultrastructure of the pineal gland in the adult rat. J Anat 138(Pt 3):405

pubmed: 6735903 pmcid: 1164325

Hardeland R (2005) Atioxidative protection by melatonin. Endocrine 27(2):119–130

pubmed: 16217125

Liu RY, Zhou JN, van Heerikhuize J, Hofman MA, Swaab DF (1999) Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer’s disease, and apolipoprotein E-ε4/4 genotype. J Clin Endocrinol Metab 84(1):323–327

pubmed: 9920102

Lin L, Huang QX, Yang SS, Chu J, Wang JZ, Tian Q (2013) Melatonin in Alzheimer’s disease. Int J Mol Sci 14(7):14575–14593

pubmed: 23857055 pmcid: 3742260

Abdel Moneim AE, Ortiz F, Leonardo-Mendonça RC, Vergano-Villodres R, Guerrero-Martínez JA, López LC, Acuña-Castroviejo D, Escames G (2015) Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats. Acta Trop 143:58–65

pubmed: 25542296

Feng Y, Wang X (2012) Antioxidant therapies for Alzheimer’s disease. Oxidative Medicine and Cellular Longevity 2012

Cardinali DP, Furio AM, Brusco LI (2010) Clinical aspects of melatonin intervention in Alzheimer’s disease progression. Curr Neuropharmacol 8(3):218–227

pubmed: 21358972 pmcid: 3001215

Jean-Louis G, von Gizycki H, Zizi F (1998) Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 25(3):177–183

pubmed: 9745987

Simpkins JW, Perez E, Wang X, Yang S, Wen Y, Singh M (2009) The potential for estrogens in preventing Alzheimer’s disease and vascular dementia. Ther Adv Neurol Disord 2(1):31–49

pubmed: 19890493 pmcid: 2771945

Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H (2002) Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem 277(14):12128–12136

pubmed: 11823458

Li R, Shen Y, Yang LB, Lue LF, Finch C, Rogers J (2000) Estrogen enhances uptake of amyloid β-protein by microglia derived from the human cortex. J Neurochem 75(4):1447–1454

pubmed: 10987824

Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE (1994) Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J Biol Chem 269(18):13065–13068

pubmed: 8175728

Benvenuti S, Luciani P, Vannelli GB, Gelmini S, Franceschi E, Serio M, Peri A (2005) Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer’s disease indicator-1, a recently discovered antiapoptotic gene, in human neuroblast long-term cell cultures. J Clin Endocrinol Metab 90(3):1775–1782

pubmed: 15585566

Asthana S, Craft S, Baker LD, Raskind MA, Birnbaum RS, Lofgreen CP, … Plymate SR (1999) Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer’s disease: results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology 24(6): 657-678

Forsmark-Andrée P, Lee CP, Dallner G, Ernster L (1997) Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radical Biol Med 22(3):391–400

Crane FL (2001) Biochemical functions of coenzyme Q10. J Am Coll Nutr 20(6):591–598

pubmed: 11771674

Ernster L, Dallner G (1995) Biochemical, physiological and medical aspects of ubiquinone function. Biochimica etBiophysica Acta 1271(1):195–204

Sharma SK, El ReFaey H, Ebadi M (2006) Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson’s disease and the neuroprotective role of coenzyme Q10. Brain Res Bull 70(1):22–32

pubmed: 16750479

Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, ... Beal MF (2011) Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer’s disease. J Alzheimers Dis 27(1), 211-223

Yang X, Yang Y, Li G, Wang J, Yang ES (2008) Coenzyme Q10 attenuates β-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. J Mol Neurosci 34(2):165–171

pubmed: 18181031

Horecky J, Gvozdjáková A, Kucharská J, Obrenovich ME, Palacios HH, Li Y, ... Aliev G (2011) Effects of coenzyme Q and creatine supplementation on brain energy metabolism in rats exposed to chronic cerebral hypoperfusion. Curr Alzheimer Res 8(8): 868-875

Tsvetkova D, Obreshkova D, Zheleva-Dimitrova D, Saso L (2013) Antioxidant activity of galantamine and some of its derivatives. Curr Med Chem 20(36):4595–4608

pubmed: 23834167

Wen C, Huang C, Yang M, Fan C, Li Q, Zhao J, ... Lu D (2020) The secretion from bone marrow Mesenchymal stem cells pretreated with Berberine rescues neurons with oxidative damage through activation of the Keap1-Nrf2-HO-1 signaling pathway. Neurotoxicity Research, 38(1): 59-73

Yang R, Wang Q, Li F, Li J, Liu X (2015) Edaravone injection ameliorates cognitive deficits in rat model of Alzheimer’s disease. Neurol Sci 36(11):2067–2072

pubmed: 26163224

Jiao SS, Yao XQ, Liu YH, Wang QH, Zeng F, Lu JJ, Liu J, Zhu C, Shen LL, Liu CH, Wang YR, Zeng GH, Parikh A, Chen J, Liang CR, Xiang Y, Bu XL, Deng J, Li J, Xu J, … Wang YJ (2015) Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits. Proc Natl Acad Sci USA 112(16): 5225-5230

Singh S, Gautam U, Manvi FV (2020) Protective impact of edaravone against ZnO NPs-induced oxidative stress in the human neuroblastoma SH-SY5Y cell line. Cell Mol Neurobiol, 1–22

Zeng KW, Wang XM, Ko H, Kwon HC, Cha JW, Yang HO (2011) Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/BclXL-regulated mitochondrial apoptotic pathway. Eur J Pharmacol 672(1–3):45–55

pubmed: 21978835

Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, ... Ohta S (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13(6): 688-694

Yoshii Y, Inoue T, Uemura Y, Iwasaki Y, Yada T, Nakabeppu Y, Noda M (2017) Complexity of stomach–brain interaction induced by molecular hydrogen in Parkinson’s disease model mice. Neurochem Res 42(9):2658–2665

pubmed: 28462451

Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, ... Fukuda K (2008) Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury. Biochem Biophys Res Commun 373(1): 30-35

Abraini JH, Gardette-Chauffour MC, Martinez E, Rostain JC, Lemaire C (1994) Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol 76(3):1113–1118

pubmed: 8005852

Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Kaneko K, ... Imaoka T (2012) A basic study on molecular hydrogen (H 2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H 2 level. Med Gas Res 2(1):1-7

Ara J, Fadriquela A, Ahmed MF, Bajgai J, Sajo MEJ, Lee SP, ... Lee KJ (2018) Hydrogen water drinking exerts antifatigue effects in chronic forced swimming mice via antioxidative and anti-inflammatory activities. BioMed Research International 2018

Jin L, Yu SQ, Zhang X, Ge Q, Zhang XL, Wang Y, Qin ML (2018) Clinical study of hydrogen-rich saline in the treatment of moderate to severe allergic rhinitis. Lin Chuang er bi yan hou tou Jing wai ke za zhi= Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery 32(7): 493-496

Koyama Y, Taura K, Hatano E, Tanabe K, Yamamoto G, Nakamura K, ... Uemoto S (2014) Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res 44(6):663-677

Ohta S (2014) Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther 144(1):1–11

pubmed: 24769081

Lin CL, Huang WN, Li HH, Huang CN, Hsieh S, Lai C, Lu FJ (2015) Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chem Biol Interact 240:12–21

pubmed: 26271894

Iuchi K, Imoto A, Kamimura N, Nishimaki K, Ichimiya H, Yokota T, Ohta S (2016) Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep 6:18971

pubmed: 26739257 pmcid: 4704061

Hou C, Peng Y, Qin C, Fan F, Liu J, Long J (2018) Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance. Free Radical Res 52(11–12):1311–1322

Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, ... Leibowitz G (2016) Autophagy is a major regulator of beta cell insulin homeostasis. Diabetologia 59(7):1480-1491

Liu X, Chen Z, Mao N, Xie Y (2012) The protective of hydrogen on stress-induced gastric ulceration. Int Immunopharmacol 13(2):197–203

pubmed: 22543062

Zhai Y, Zhou X, Dai Q, Fan Y, Huang X (2015) Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol 98(2):268–276

pubmed: 25746665

Fukuda M, Takatori A, Nakamura Y, Suganami A, Hoshino T, Tamura Y, Nakagawara A (2016) Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior. Neurochem Int 97:42–48

pubmed: 27166149

Cui Y, Zhang H, Ji M, Jia M, Chen H, Yang J, Duan M (2014) Hydrogen-rich saline attenuates neuronal ischemia–reperfusion injury by protecting mitochondrial function in rats. J Surg Res 192(2):564–572

pubmed: 24969549

Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, ... Toyokuni S (2014) Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia–reperfusion. Free Radic Biol Med 69: 324-330

Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S (2009) Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 34(2):501–508

pubmed: 18563058

Li J, Wang C, Zhang JH, Cai JM, Cao YP, Sun XJ (2010) Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res 1328:152–161

pubmed: 20171955

Wang C, Li J, Liu Q, Yang R, Zhang JH, Cao YP, Sun XJ (2011) Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neurosci Lett 491(2):127–132

pubmed: 21238541

Hollands C, Tobin MK, Hsu M, Musaraca K, Yu TS, Mishra R, ... Lazarov O (2017) Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition. Mol Neurodegener 12(1):1-13

Radad K, Moldzio R, Al-Shraim M, Kranner B, Krewenka C, Rausch WD (2017) Recent advances on the role of neurogenesis in the adult brain: therapeutic potential in Parkinson’s and Alzheimer’s diseases. CNS Neurol Disord Drug Targets 16(7):740–748

pubmed: 28641510

Gu Y, Huang CS, Inoue T, Yamashita T, Ishida T, Kang KM, Nakao A (2010) Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. J Clin Biochem Nutr 46(3):269–276

pubmed: 20490324 pmcid: 2872234

Nishimaki K, Asada T, Ohsawa I, Nakajima E, Ikejima C, Yokota T, Kamimura N, Ohta S (2018) Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Curr Alzheimer Res 15(5):482–492

pubmed: 29110615 pmcid: 5872374

Sim M, Kim CS, Shon WJ, Lee YK, Choi EY, Shin DM (2020) Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: A randomized, double-blind, controlled trial. Sci Rep 10(1):1–10

Butler M, Nelson VA, Davila H, Ratner E, Fink HA, Hemmy LS, McCarten JR, Barclay TR, Brasure M, Kane RL (2018) Over-the-counter supplement interventions to prevent cognitive decline, mild cognitive impairment, and clinical alzheimer-type dementia: a systematic review. Ann Intern Med 168(1):52–62

pubmed: 29255909

Mullan K, Cardwell CR, McGuinness B, Woodside JV, McKay GJ (2018) Plasma antioxidant status in patients with Alzheimer’s disease and cognitively intact elderly: a meta-analysis of case-control studies. J Alzheimers Dis 62(1):305–317

pubmed: 29439339

Cornelli U (2010) Treatment of Alzheimer’s disease with a cholinesterase inhibitor combined with antioxidants. Neurodegener Dis 7(1–3):193–202

pubmed: 20224285

Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB (2010) A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging 14(3):224–230

pubmed: 20191258

Remington R, Bechtel C, Larsen D, Samar A, Doshanjh L, Fishman P, Luo Y, Smyers K, Page R, Morrell C, Shea TB (2015) A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer’s disease. J Alzheimers Dis 45(2):395–405

pubmed: 25589719

Remington R, Bechtel C, Larsen D, Samar A, Page R, Morrell C, Shea TB (2016) Maintenance of cognitive performance and mood for individuals with Alzheimer’s disease following consumption of a nutraceutical formulation: a one-year, open-label study. J Alzheimers Dis 51(4):991–995

pubmed: 26967219

Chew EY, Clemons TE, Agrón E, Launer LJ, Grodstein F, Bernstein PS, age-related eye disease study 2 (AREDS2) research group (2015) Effect of omega-3 fatty acids, lutein/zeaxanthin, or other nutrient supplementation on cognitive function: the areds2 randomized clinical trial. JAMA 314(8):791–801

pubmed: 26305649 pmcid: 5369607

Kryscio RJ, Abner EL, Caban-Holt A, Lovell M, Goodman P, Darke AK, Yee M, Crowley J, Schmitt FA (2017) Association of antioxidant supplement use and dementia in the prevention of Alzheimer’s disease by vitamin E and selenium trial (PREADViSE). JAMA Neurol 74(5):567–573

pubmed: 28319243 pmcid: 5506489

Schrag M, Mueller C, Zabel M, Crofton A, Kirsch WM, Ghribi O, Squitti R, Perry G (2013) Oxidative stress in blood in Alzheimer’s disease and mild cognitive impairment: a meta-analysis. Neurobiol Dis 59:100–110

pubmed: 23867235

Ahmed T, Javed S, Javed S, Tariq A, Šamec D, Tejada S, ... Nabavi SM (2017) Resveratrol and Alzheimer’s disease: mechanistic insights. Mol Neurobiol 54(4): 2622-2635

Adair JC, Knoefel JE, Morgan N (2001) Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease. Neurology 57(8):1515–1517

pubmed: 11673605

Di Domenico F, Barone E, Perluigi M, Butterfield DA (2015) Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants. Expert Rev Neurother 15(1):19–40

pubmed: 25243342

Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM (2002) Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 287(24):3223–3229

pubmed: 12076218

Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, ... Scherr PA (2002) Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287(24): 3230-3237

Hsu CH, Cheng AL (2007) Clinical studies with curcumin. In: The molecular targets and therapeutic uses of curcumin in health and disease, 471–480

Misonou H, Morishima-Kawashima M, Ihara Y (2000) Oxidative stress induces intracellular accumulation of amyloid β-protein (Aβ) in human neuroblastoma cells. Biochemistry 39(23):6951–6959

pubmed: 10841777

Paola D, Domenicotti C, Nitti M, Vitali A, Borghi R, Cottalasso D, ... Pronzato MA (2000) Oxidative stress induces increase in intracellular amyloid β-protein production and selective activation of βI and βII PKCs in NT2 cells. Biochem Biophys Res Commun 268(2): 642-646

Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N (2008) Hydrogen peroxide promotes Aβ production through JNK-dependent activation of γ-secretase. J Biol Chem 283(25):17721–17730

pubmed: 18436531 pmcid: 2427353

Persson T, Popescu BO, Cedazo-Minguez A (2014) Oxidative stress in Alzheimer’s disease: why did antioxidant therapy fail? Oxid Med Cell Longev 2014:427318

pubmed: 24669288 pmcid: 3941783

Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, ... Aisen P (2012) Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol 69(7):836-841

Berr C, Richard MJ, Gourlet V, Garrel C, Favier A (2004) Enzymatic antioxidant balance and cognitive decline in aging—the EVA study. Eur J Epidemiol 19(2):133–138

pubmed: 15074569

Torres LL, Quaglio NB, de Souza GT, Garcia RT, Dati LMM, Moreira WL, ... Marcourakis T (2011) Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 26(1):59-68

Terada A, Yoshida M, Seko Y, Kobayashi T, Yoshida K, Nakada M, …& Rikihisa, T. (1999) Active oxygen species generation and cellular damage by additives of parenteral preparations: selenium and sulfhydryl compounds. Nutrition 15(9):651–655

pubmed: 10467607

Kwong LK, Kamzalov S, Rebrin I, Bayne ACV, Jana CK, Morris P, …& Sohal, R. S. (2002) Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radical Biol Med 33(5):627–638

Thal LJ, Grundman M, Berg J, Ernstrom K, Margolin R, Pfeiffer E, ... Thomas RG (2003) Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease. Neurology 61(11):1498-1502

Sung S, Yao Y, Uryu K, Yang H, Lee VMY, Trojanowski JQ, Praticò D (2004) Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer’s disease. FASEB J 18(2):323–325

pubmed: 14656990

Avila J (2010) Common mechanisms in neurodegeneration. Nat Med 16(12):1372–1372

pubmed: 21135842

Butterfield SM, Lashuel HA (2010) Amyloidogenic protein–membrane interactions: mechanistic insight from model systems. Angew Chem Int Ed 49(33):5628–5654

Di Domenico F, Barone E, Perluigi M, Butterfield DA (2017) The triangle of death in Alzheimer’s disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox proteomics. Antioxid Redox Signal 26(8):364–387

pubmed: 27626216

Fillenbaum GG, Kuchibhatla MN, Hanlon JT, Artz MB, Pieper CF, Schmader KE, Dysken MW, Gray SL (2005) Dementia and Alzheimer’s disease in community-dwelling elders taking vitamin C and/or vitamin E. Ann Pharmacother 39(12):2009–2014

pubmed: 16227448

Goedert M, Hasegawa M, Jakes R, Lawler S, Cuenda A, Cohen P (1997) Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases. FEBS Lett 409(1):57–62

pubmed: 9199504

González-Muñoz GC, Arce MP, Pérez C, Romero A, Villarroya M, López MG, ... Rodríguez-Franco MI (2014) Dibenzo [1, 4, 5] thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases. Eur J Med Chem 81: 350-358

Isaac MGEKN, Quinn R, Tabet N (2008) Vitamin E for Alzheimer’s disease and mild cognitive impairment. Cochrane Database of Systematic Reviews, (3)

Rafieipour F, Hadipour E, Emami SA, Asili J, Tayarani-Najaran Z (2019) Safranal protects against beta-amyloid peptide-induced cell toxicity in PC12 cells via MAPK and PI3 K pathways. Metab Brain Dis 34(1):165–172

pubmed: 30402809

Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH (2000) Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3β. J Neurochem 74(4):1587–1595

pubmed: 10737616

Reynolds CH, Nebreda AR, Gibb GM, Utton MA, Anderton BH (1997) Reactivating kinase/p38 phosphorylates τ protein in vitro. J Neurochem 69(1):191–198

pubmed: 9202310

Richardson TIL, Ball L, Rosenfeld T (2002) Will an orange a day keep the doctor away? Postgrad Med J 78(919):292–294

pubmed: 12151575 pmcid: 1742354

Schweizer U, Streckfuß F, Pelt P, Carlson BA, Hatfield DL, Köhrle J, Schomburg L (2005) Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply. Biochem J 386(2):221–226

pubmed: 15638810 pmcid: 1134785

Tahirbegi IB, Pardo WA, Alvira M, Mir M, Samitier J (2016) Amyloid Aβ 42, a promoter of magnetite nanoparticle formation in Alzheimer’s disease. Nanotechnology 27(46):465102

pubmed: 27734811

Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270(5240):1326–1331

pubmed: 7481820

Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer's Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside.

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Vaibhav Walia (V)

Deepak Kaushik (D)

Vineet Mittal (V)

Kuldeep Kumar (K)

Ravinder Verma (R)

Jatin Parashar (J)

Rokeya Akter (R)

Md Habibur Rahman (MH)

Saurabh Bhatia (S)

Ahmed Al-Harrasi (A)

Chenmala Karthika (C)

Tanima Bhattacharya (T)

Hitesh Chopra (H)

Ghulam Md Ashraf (GM)

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