A case of systemic sarcoidosis with mesangial proliferative glomerulonephritis showing predominant deposition of IgG in the mesangial region.
IgG
Mesangial proliferative glomerulonephritis
Systemic sarcoidosis
Journal
CEN case reports
ISSN: 2192-4449
Titre abrégé: CEN Case Rep
Pays: Japan
ID NLM: 101636244
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
06
10
2021
accepted:
01
11
2021
pubmed:
10
11
2021
medline:
6
5
2022
entrez:
9
11
2021
Statut:
ppublish
Résumé
A 37-year-old African-British man was referred to our hospital for detailed examination because of persistent fever, swelling and pain in both ankle joints, and blurred vision for two months. Inguinal lymph node biopsy showed a large number of epithelioid granulomas without necrosis. Granulomatous anterior uveitis, nephropathy, high serum angiotensin-converting enzyme activity, and high serum-soluble interleukin-2 receptor were observed, and the diagnosis of systemic sarcoidosis was made. His serum creatinine was 1.4 mg/dL and hematuria, leukocyturia, and urine protein were also seen. The renal biopsy finding was mesangial proliferative glomerulonephritis, with no findings of granuloma formation or tubular interstitial nephritis. Immunofluorescence staining showed deposition of IgG, C3, and C1q in the mesangial region. IgG3 was dominant in subclass staining. There was no monoclonality on kappa and lambda staining. Electron microscopy showed predominant deposition in the mesangial region with some subepithelial and endothelial deposition. His hematuria and leukocyturia disappeared with steroid therapy, suggesting sarcoidosis-related nephropathy. A case of systemic sarcoidosis with mesangial proliferative glomerulonephritis showing predominant deposition of IgG in the mesangial region is presented. No cases of such histological findings have been reported so far, and it is necessary to analyze further cases to clarify the pathogenic significance of the renal biopsy findings observed in this case.
Identifiants
pubmed: 34751926
doi: 10.1007/s13730-021-00660-4
pii: 10.1007/s13730-021-00660-4
pmc: PMC9061903
doi:
Substances chimiques
Immunoglobulin G
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
231-236Informations de copyright
© 2021. Japanese Society of Nephrology.
Références
Acta Med Scand. 1957 Dec 12;159(4):295-305
pubmed: 13508097
Turk J Pediatr. 2004 Oct-Dec;46(4):366-9
pubmed: 15641274
J Med Case Rep. 2015 Dec 14;9:282
pubmed: 26651490
Am J Kidney Dis. 2005 Mar;45(3):580-7
pubmed: 15754281
Mod Pathol. 2013 May;26(5):709-15
pubmed: 23196797
Mod Rheumatol. 2013 Jan;23(1):146-50
pubmed: 22350640
Klin Med (Mosk). 2005;83(6):83-6
pubmed: 16075654
Intern Med. 2021 Dec 15;60(24):3927-3935
pubmed: 34148959
Respir Med Case Rep. 2020 Aug 28;31:101202
pubmed: 32944498
Sarcoidosis Vasc Diffuse Lung Dis. 2003 Jun;20(2):126-32
pubmed: 12870722
Nefrologia. 2013;33(3):431-3
pubmed: 23712235
Isr Med Assoc J. 2014 Jun;16(6):390-2
pubmed: 25059006
Clin Exp Nephrol. 2006 Mar;10(1):68-73
pubmed: 16544180
Nephrol Dial Transplant. 2015 Jun;30(6):1047-50
pubmed: 25839741
Nephron. 2002 Feb;90(2):211-2
pubmed: 11818707
Iran J Kidney Dis. 2019 Sep;13(5):340-342
pubmed: 31705752
MedGenMed. 2005 Mar 30;7(1):7
pubmed: 16369312
Nephrol Dial Transplant. 1997 Jul;12(7):1474-7
pubmed: 9249790
Orphanet J Rare Dis. 2013 Apr 30;8:65
pubmed: 23631446
Sarcoidosis Vasc Diffuse Lung Dis. 2015 Jan 05;31(4):306-15
pubmed: 25591142
An Med Interna. 2002 Dec;19(12):632-4
pubmed: 12593032
Am J Kidney Dis. 2011 Jan;57(1):140-3
pubmed: 21087816
Am J Kidney Dis. 1994 Mar;23(3):358-64
pubmed: 8128936
Intern Med. 2019 Nov 15;58(22):3299-3304
pubmed: 31327832
Sarcoidosis Vasc Diffuse Lung Dis. 2003 Mar;20(1):69-73
pubmed: 12737283
Postgrad Med J. 1978 Aug;54(634):528-32
pubmed: 733683
Saudi J Kidney Dis Transpl. 2018 Jul-Aug;29(4):979-984
pubmed: 30152439
Nephrol Dial Transplant. 2013 Jul;28(7):1839-44
pubmed: 23223223
Nefrologia. 2007;27(1):83-4
pubmed: 17402886
Postgrad Med J. 1970 Aug;46(538):526-9
pubmed: 5481106