Treatment of Delirium During Critical Illness.
delirium
intensive care
mechanical ventilation
treatment
Journal
Annual review of medicine
ISSN: 1545-326X
Titre abrégé: Annu Rev Med
Pays: United States
ID NLM: 2985151R
Informations de publication
Date de publication:
27 01 2022
27 01 2022
Historique:
pubmed:
10
11
2021
medline:
22
3
2022
entrez:
9
11
2021
Statut:
ppublish
Résumé
Delirium, an acute disturbance in mental status due to another medical condition, is common and morbid in the intensive care unit. Despite its clear association with multiple common risk factors and important outcomes, including mortality and long-term cognitive impairment, both the ultimate causes of and ideal treatments for delirium remain unclear. Studies suggest that neuroinflammation, hypoxia, alterations in energy metabolism, and imbalances in multiple neurotransmitter pathways contribute to delirium, but commonly used treatments (e.g., antipsychotic medications) target only one or a few of these potential mechanisms and are not supported by evidence of efficacy. At this time, the optimal treatment for delirium during critical illness remains avoidance of risk factors, though ongoing trials may expand on the promise shown by agents such as melatonin and dexmedetomidine.
Identifiants
pubmed: 34752706
doi: 10.1146/annurev-med-042220-013015
pmc: PMC9400521
mid: NIHMS1831012
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
407-421Subventions
Organisme : NHLBI NIH HHS
ID : F32 HL158058
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007563
Pays : United States
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