The association of cytomegalovirus infection and cytomegalovirus serostatus with invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients: a systematic review and meta-analysis.
Allogeneic stem cell transplantation
Bone marrow transplantation
CMV
CMV serostatus
Cytomegalovirus
Invasive fungal infection
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
17
07
2021
revised:
20
09
2021
accepted:
17
10
2021
pubmed:
10
11
2021
medline:
16
3
2022
entrez:
9
11
2021
Statut:
ppublish
Résumé
In allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients, the inter-relationship between post-transplant cytomegalovirus (CMV) and subsequent invasive fungal infections (IFIs) is conflicting and the association of CMV serostatus with IFIs has not been evaluated. To determine the relationship between CMV infection/serostatus and IFIs in allo-HSCT populations. A systematic literature search was conducted from existence until 11 July 2021 using Medline, Embase and ISI Web of Science databases. Cross-sectional, prospective cohort, retrospective cohort and case-control studies that reported allo-HSCT recipients with CMV and without CMV who developed or did not develop IFIs after CMV infection. Allo-HSCT recipients. Not applicable. A systematic search, screening, data extracting and assessing study quality were independently conducted by two reviewers. The Newcastle-Ottawa scale was used to assess risk of bias. data were analysed using the pooled effect estimates of a random-effects model. A total of 18 and 12 studies were included for systematic review and meta-analysis, respectively. Post-transplant CMV infection significantly increased the risk of IFIs with a pooled hazard ratio (pHR) of 2.58 (1.78, 3.74), I Post-transplant CMV infection and high-risk CMV serostatus increased the risk of IFIs, but low-risk CMV serostatus decreased risk of IFIs among allo-HSCT recipients. Further studies are needed to identify at-risk allo-HSCT recipients as well as to focus on fungal diagnostics and prophylaxis to prevent this fungal-after-viral phenomenon.
Sections du résumé
BACKGROUND
BACKGROUND
In allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients, the inter-relationship between post-transplant cytomegalovirus (CMV) and subsequent invasive fungal infections (IFIs) is conflicting and the association of CMV serostatus with IFIs has not been evaluated.
OBJECTIVES
OBJECTIVE
To determine the relationship between CMV infection/serostatus and IFIs in allo-HSCT populations.
DATA SOURCES
METHODS
A systematic literature search was conducted from existence until 11 July 2021 using Medline, Embase and ISI Web of Science databases.
STUDY ELIGIBILITY CRITERIA
METHODS
Cross-sectional, prospective cohort, retrospective cohort and case-control studies that reported allo-HSCT recipients with CMV and without CMV who developed or did not develop IFIs after CMV infection.
PARTICIPANTS
METHODS
Allo-HSCT recipients.
INTERVENTIONS
METHODS
Not applicable.
METHODS
METHODS
A systematic search, screening, data extracting and assessing study quality were independently conducted by two reviewers. The Newcastle-Ottawa scale was used to assess risk of bias. data were analysed using the pooled effect estimates of a random-effects model.
RESULTS
RESULTS
A total of 18 and 12 studies were included for systematic review and meta-analysis, respectively. Post-transplant CMV infection significantly increased the risk of IFIs with a pooled hazard ratio (pHR) of 2.58 (1.78, 3.74), I
CONCLUSIONS
CONCLUSIONS
Post-transplant CMV infection and high-risk CMV serostatus increased the risk of IFIs, but low-risk CMV serostatus decreased risk of IFIs among allo-HSCT recipients. Further studies are needed to identify at-risk allo-HSCT recipients as well as to focus on fungal diagnostics and prophylaxis to prevent this fungal-after-viral phenomenon.
Identifiants
pubmed: 34752926
pii: S1198-743X(21)00607-8
doi: 10.1016/j.cmi.2021.10.008
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
332-344Informations de copyright
Copyright © 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.