Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile.
Anthelmintic resistance
Drug resistance
Nematodes
P-glycoprotein
Toxocariasis
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
20
04
2021
revised:
18
10
2021
accepted:
18
10
2021
pubmed:
10
11
2021
medline:
7
1
2022
entrez:
9
11
2021
Statut:
ppublish
Résumé
P-glycoproteins from the ATP-binding cassette transporter family are responsible for drug evasion by bacterial pathogens and neoplastic cells. More recently, these multidrug resistance transporters have been investigated for contributions to drug resistance in nematode parasites. In this study, we cloned and characterized the P-glycoprotein Tca-Pgp-11.1 from Toxocara canis, the canine intestinal ascarid. Large numbers of Tca-Pgp-11 transcripts were observed in the intestine of adult male and female worms. Heterologous expression studies confirmed sensitivity to known P-glycoprotein inhibitors. Interestingly, the competitive inhibitor verapamil had lower IC
Identifiants
pubmed: 34753107
pii: S2211-3207(21)00051-8
doi: 10.1016/j.ijpddr.2021.10.002
pmc: PMC8586496
pii:
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B
0
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Anthelmintics
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-203Subventions
Organisme : NIAID NIH HHS
ID : R21 AI144493
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.