Proteomics in Thrombosis and Hemostasis.

Biomarkers Blood Platelets / metabolism Hemostasis Humans Proteome / metabolism Proteomics / methods Thrombosis

Journal

Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063

Informations de publication

Date de publication:
Jul 2022
Historique:
pubmed: 10 11 2021
medline: 20 8 2022
entrez: 9 11 2021
Statut: ppublish

Résumé

Proteomics, the simultaneous study of all proteins in a given cell, tissue or organism, is an innovative approach used to identify novel markers for diagnosis, prognosis and the pathophysiological mechanisms associated with diseases. Proteomic methodologies have been used in a variety of contexts such as investigating changes in protein abundance that may occur with disease presence, the response to therapeutic treatments as well as the impacts of age on the plasma proteome.Over the last decade, significant technological advancements in proteomic techniques have resulted in an increase in the use of proteomics in thrombosis and hemostasis research, particularly in order to identify relevant and novel clinical markers associated with bleeding and thrombosis. This mini-review explores the use of proteomics in the setting of thrombosis and hemostasis from 2010-2020, across five main domains (platelets, blood clot composition, stroke, venous thromboembolism, and therapeutics), as well as provides insights into key considerations for conducting proteomic studies.

Identifiants

DOI: 10.1055/a-1690-8897 PMID: 34753192
pubmed: 34753192
doi: 10.1055/a-1690-8897
doi:

Substances chimiques

Biomarkers 0
Proteome 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1076-1084

Informations de copyright

Thieme. All rights reserved.

Déclaration de conflit d'intérêts

None declared.

Auteurs

Natasha Letunica (N)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.

Suelyn Van Den Helm (S)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.

Conor McCafferty (C)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Ella Swaney (E)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Tengyi Cai (T)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Chantal Attard (C)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Vasiliki Karlaftis (V)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Paul Monagle (P)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
Department of Clinical Haematology, Royal Children's Hospital, Melbourne, Australia.
Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.

Vera Ignjatovic (V)

Department of Haematology, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Proteomics in Thrombosis and Hemostasis.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Proteomics in Thrombosis and Hemostasis.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Proteomics in Thrombosis and Hemostasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Proteomics in Thrombosis and Hemostasis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Proteomics in Thrombosis and Hemostasis.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Proteomics in Thrombosis and Hemostasis.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Proteomics in Thrombosis and Hemostasis.