LINC00857 promotes colorectal cancer progression by sponging miR-150-5p and upregulating HMGB3 (high mobility group box 3) expression.
Animals
Apoptosis
/ genetics
Base Sequence
Carcinogenesis
/ genetics
Cell Line, Tumor
Cell Movement
Cell Proliferation
Colorectal Neoplasms
/ genetics
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
HMGB3 Protein
/ genetics
Humans
Male
Mice, Inbred BALB C
Mice, Nude
MicroRNAs
/ genetics
Middle Aged
Neoplasm Invasiveness
RNA, Long Noncoding
/ genetics
Up-Regulation
/ genetics
HMGB3
LINC00857
TCGA
colorectal cancer
miR-150-5p
Journal
Bioengineered
ISSN: 2165-5987
Titre abrégé: Bioengineered
Pays: United States
ID NLM: 101581063
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
pubmed:
11
11
2021
medline:
16
2
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is the third most commonly diagnosed malignant tumor worldwide. LINC00857 has been reported as a dysregulated long non-coding RNAs (lncRNAs) involved in the genesis and development of different cancers. In CRC, accumulating evidence indicates that high mobility group box 3 (HMGB3) is over-expressed and contributes to CRC development. However, the mechanism underlying HMGB3 upregulation in CRC remains unclear. The present work aims to investigate the role of LINC00857 and its functional interaction with HMGB3 in regulating CRC progression. Differential expression of LINC00857 between CRC tissues and normal tissues was identified in TCGA (The Cancer Genome Atlas) database.
Identifiants
pubmed: 34753396
doi: 10.1080/21655979.2021.2003941
pmc: PMC8810051
doi:
Substances chimiques
HMGB3 Protein
0
LINC00857 lnc, human
0
MIRN150 microRNA, human
0
MicroRNAs
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12107-12122Références
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