Diet composition influences the metabolic benefits of short cycles of very low caloric intake.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 11 2021
09 11 2021
Historique:
received:
15
01
2021
accepted:
14
10
2021
entrez:
10
11
2021
pubmed:
11
11
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Diet composition, calories, and fasting times contribute to the maintenance of health. However, the impact of very low-calorie intake (VLCI) achieved with either standard laboratory chow (SD) or a plant-based fasting mimicking diet (FMD) is not fully understood. Here, using middle-aged male mice we show that 5 months of short 4:10 VLCI cycles lead to decreases in both fat and lean mass, accompanied by improved physical performance and glucoregulation, and greater metabolic flexibility independent of diet composition. A long-lasting metabolomic reprograming in serum and liver is observed in mice on VLCI cycles with SD, but not FMD. Further, when challenged with an obesogenic diet, cycles of VLCI do not prevent diet-induced obesity nor do they elicit a long-lasting metabolic memory, despite achieving modest metabolic flexibility. Our results highlight the importance of diet composition in mediating the metabolic benefits of short cycles of VLCI.
Identifiants
pubmed: 34753921
doi: 10.1038/s41467-021-26654-5
pii: 10.1038/s41467-021-26654-5
pmc: PMC8578605
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6463Subventions
Organisme : NIA NIH HHS
ID : P01 AG055369
Pays : United States
Organisme : NIGMS NIH HHS
ID : FI2 GM123963
Pays : United States
Informations de copyright
© 2021. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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