Diabetic kidney disease: Are the reported associations with single-nucleotide polymorphisms disease-specific?
Chronic kidney disease
Diabetes mellitus
Diabetic kidney disease
End-stage kidney disease
Single-nucleotide polymorphism
Journal
World journal of diabetes
ISSN: 1948-9358
Titre abrégé: World J Diabetes
Pays: United States
ID NLM: 101547524
Informations de publication
Date de publication:
15 Oct 2021
15 Oct 2021
Historique:
received:
16
03
2021
revised:
26
05
2021
accepted:
07
09
2021
entrez:
10
11
2021
pubmed:
11
11
2021
medline:
11
11
2021
Statut:
ppublish
Résumé
The genetic backgrounds of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) have not been fully elucidated. To examine the individual and cumulative effects of single-nucleotide polymorphisms (SNPs) previously associated with DKD on the risk for ESKD of diabetic etiology and to determine if any associations observed were specific for DKD. Fourteen SNPs were genotyped in hemodialyzed 136 patients with diabetic ESKD (DKD group) and 121 patients with non-diabetic ESKD (NDKD group). Patients were also re-classified on the basis of the primary cause of chronic kidney disease (CKD). The distribution of alleles was compared between diabetic and non-diabetic groups as well as between different sub-phenotypes. The weighted multilocus genetic risk score (GRS) was calculated to estimate the cumulative risk conferred by all SNPs. The GRS distribution was then compared between the DKD and NDKD groups as well as in the groups according to the primary cause of CKD. One SNP (rs841853; SLC2A1) showed a nominal association with DKD ( Our results suggest that selected SNPs that were previously associated with DKD may not be specific for DKD and may confer risk for CKD of different etiology, particularly those affecting renal glomeruli.
Sections du résumé
BACKGROUND
BACKGROUND
The genetic backgrounds of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) have not been fully elucidated.
AIM
OBJECTIVE
To examine the individual and cumulative effects of single-nucleotide polymorphisms (SNPs) previously associated with DKD on the risk for ESKD of diabetic etiology and to determine if any associations observed were specific for DKD.
METHODS
METHODS
Fourteen SNPs were genotyped in hemodialyzed 136 patients with diabetic ESKD (DKD group) and 121 patients with non-diabetic ESKD (NDKD group). Patients were also re-classified on the basis of the primary cause of chronic kidney disease (CKD). The distribution of alleles was compared between diabetic and non-diabetic groups as well as between different sub-phenotypes. The weighted multilocus genetic risk score (GRS) was calculated to estimate the cumulative risk conferred by all SNPs. The GRS distribution was then compared between the DKD and NDKD groups as well as in the groups according to the primary cause of CKD.
RESULTS
RESULTS
One SNP (rs841853; SLC2A1) showed a nominal association with DKD (
CONCLUSION
CONCLUSIONS
Our results suggest that selected SNPs that were previously associated with DKD may not be specific for DKD and may confer risk for CKD of different etiology, particularly those affecting renal glomeruli.
Identifiants
pubmed: 34754377
doi: 10.4239/wjd.v12.i10.1765
pmc: PMC8554375
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1765-1777Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare that they have no competing financial interests. No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
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