Temporary opening of the blood-brain barrier with the nitrone compound OKN-007.
BBB
Eph-B2
Gd-DOTA
Gd-DTPA
Gd-DTPA-albumin-biotin
OKN-007
contrast-enhanced MRI
in vivo
mice
molecular-targeted MRI
β-galactosidase
Journal
American journal of nuclear medicine and molecular imaging
ISSN: 2160-8407
Titre abrégé: Am J Nucl Med Mol Imaging
Pays: United States
ID NLM: 101564121
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
08
2021
accepted:
22
09
2021
entrez:
10
11
2021
pubmed:
11
11
2021
medline:
11
11
2021
Statut:
epublish
Résumé
The blood-brain barrier (BBB) is usually impermeable to several drugs, which hampers treatment of various brain-related diseases/disorders. There have been several approaches to open the BBB, including intracarotid infusion of hyperosmotic concentrations of arabinose, mannitol, oleic or linoleic acids, or alkylglycerols, intravenous infusion of bradykinin B2, administration of a fragment of the ZO toxin from
Types de publication
Journal Article
Langues
eng
Pagination
363-373Informations de copyright
AJNMMI Copyright © 2021.
Déclaration de conflit d'intérêts
RAT holds a patent regarding the use of OKN-007 to temporarily open up the BBB. All other co-authors have no conflicts of interest.
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