Characterization of Apicomplexan Amino Acid Transporters (ApiATs) in the Malaria Parasite Plasmodium falciparum.
Amino Acid Transport Systems
/ metabolism
Cell Membrane
/ metabolism
Erythrocytes
/ parasitology
Fluorescence Resonance Energy Transfer
/ methods
Green Fluorescent Proteins
/ metabolism
Host-Parasite Interactions
Humans
Malaria, Falciparum
Plasmodium falciparum
/ genetics
Protozoan Proteins
/ genetics
Plasmodium falciparum
malaria
parasitology
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
22 12 2021
22 12 2021
Historique:
pubmed:
11
11
2021
medline:
12
2
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
During the symptomatic human blood phase, malaria parasites replicate within red blood cells. Parasite proliferation relies on the uptake of nutrients, such as amino acids, from the host cell and blood plasma, requiring transport across multiple membranes. Amino acids are delivered to the parasite through the parasite-surrounding vacuolar compartment by specialized nutrient-permeable channels of the erythrocyte membrane and the parasitophorous vacuole membrane (PVM). However, further transport of amino acids across the parasite plasma membrane (PPM) is currently not well characterized. In this study, we focused on a family of Apicomplexan amino acid transporters (ApiATs) that comprises five members in Plasmodium falciparum. First, we localized four of the P. falciparum ApiATs (
Identifiants
pubmed: 34756057
doi: 10.1128/mSphere.00743-21
pmc: PMC8579892
doi:
Substances chimiques
Amino Acid Transport Systems
0
Protozoan Proteins
0
Green Fluorescent Proteins
147336-22-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0074321Références
Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2045-9
pubmed: 9050902
Science. 2018 Mar 16;359(6381):1259-1263
pubmed: 29590075
J Protozool. 1985 Feb;32(1):59-64
pubmed: 3886898
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8840-5
pubmed: 16731623
mSphere. 2021 May 19;6(3):
pubmed: 34011691
Science. 1987 Jun 26;236(4809):1661-6
pubmed: 3299700
Front Cell Dev Biol. 2021 Mar 25;9:649184
pubmed: 33842474
Mol Biochem Parasitol. 2011 May;177(1):29-34
pubmed: 21251930
Mol Biochem Parasitol. 1985 Mar;14(3):313-22
pubmed: 3887158
Malar J. 2020 Apr 8;19(1):147
pubmed: 32268910
J Mol Biol. 2011 Jan 28;405(4):956-71
pubmed: 21087616
PLoS Pathog. 2012;8(10):e1002964
pubmed: 23093935
Nat Commun. 2016 Apr 11;7:11191
pubmed: 27064065
mBio. 2019 Jul 30;10(4):
pubmed: 31363031
Methods Enzymol. 2012;506:81-92
pubmed: 22341220
Biochem J. 2014 Jan 1;457(1):1-18
pubmed: 24325549
Nat Methods. 2017 Apr;14(4):450-456
pubmed: 28288121
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5283-4
pubmed: 23513214
Cell Microbiol. 2018 Jan;20(1):
pubmed: 28902970
J Protozool. 1983 May;30(2):367-70
pubmed: 6313915
Sci Rep. 2011;1:118
pubmed: 22355635
PLoS Pathog. 2021 Aug 25;17(8):e1009835
pubmed: 34432856
Nat Biotechnol. 2010 Jan;28(1):91-8
pubmed: 20037583
Cell. 2019 Nov 14;179(5):1112-1128.e26
pubmed: 31730853
Nat Commun. 2016 Jan 22;7:10519
pubmed: 26796412
Sci Rep. 2017 Jun 22;7(1):4072
pubmed: 28642498
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3278-87
pubmed: 23112171
PLoS Pathog. 2016 May 11;12(5):e1005618
pubmed: 27168322
Int J Parasitol. 2011 Jan;41(1):125-35
pubmed: 20851123
PLoS Biol. 2019 Sep 30;17(9):e3000473
pubmed: 31568532
Bioinformatics. 2015 Oct 15;31(20):3359-61
pubmed: 26069263
Genome Biol. 2005;6(3):R26
pubmed: 15774027
mSphere. 2020 Jan 8;5(1):
pubmed: 31915223
PLoS One. 2013 Aug 30;8(8):e73783
pubmed: 24023691
Malar J. 2015 Jul 16;14:274
pubmed: 26173856
Mol Microbiol. 2010 Apr;76(1):12-24
pubmed: 20141604
PLoS Pathog. 2011 Feb;7(2):e1001292
pubmed: 21379342
Cell Host Microbe. 2009 Feb 19;5(2):191-9
pubmed: 19218089
Wellcome Open Res. 2018 May 3;3:52
pubmed: 29862326
PLoS Pathog. 2021 Aug 5;17(8):e1009816
pubmed: 34352043
Biol Rev Camb Philos Soc. 2020 Apr;95(2):305-332
pubmed: 31701663
Proc Int Conf Intell Syst Mol Biol. 1998;6:175-82
pubmed: 9783223
Metabolites. 2021 Jan 20;11(2):
pubmed: 33498308
Trends Parasitol. 2020 Jun;36(6):520-532
pubmed: 32340866
Cell Rep. 2020 Jun 23;31(12):107817
pubmed: 32579913
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Mol Microbiol. 2003 Jul;49(1):179-91
pubmed: 12823820
Nucleic Acids Res. 2009 Jan;37(Database issue):D539-43
pubmed: 18957442
Metabolites. 2021 Jul 23;11(8):
pubmed: 34436417
Mol Microbiol. 2019 May;111(5):1167-1181
pubmed: 30402958
PLoS Pathog. 2019 Jul 11;15(7):e1007906
pubmed: 31295334
BMC Genomics. 2011 Nov 30;12:587
pubmed: 22129310
Cell Host Microbe. 2019 Jan 9;25(1):166-173.e5
pubmed: 30581113
Nat Methods. 2005 Jun;2(6):415-8
pubmed: 15908919
J Parasitol. 1979 Jun;65(3):418-20
pubmed: 383936
Nature. 1993 Apr 15;362(6421):643-6
pubmed: 7681937
J Cell Biol. 2020 Jun 1;219(6):
pubmed: 32346721
mSphere. 2021 Oct 27;6(5):e0061421
pubmed: 34494883
PLoS Pathog. 2019 Feb 11;15(2):e1007577
pubmed: 30742695
Nat Commun. 2015 Nov 04;6:8775
pubmed: 26531182
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):531-6
pubmed: 23267069
Nat Commun. 2017 Feb 16;8:14455
pubmed: 28205520
J Biol Chem. 1994 Feb 4;269(5):3339-47
pubmed: 8106373
Parasitology. 1986 Oct;93 ( Pt 2):263-74
pubmed: 3537921
Microbiol Mol Biol Rev. 1998 Mar;62(1):1-34
pubmed: 9529885
Antimicrob Agents Chemother. 2004 May;48(5):1803-6
pubmed: 15105138
Eukaryot Cell. 2006 Feb;5(2):272-6
pubmed: 16467468
J Cell Sci. 2005 Dec 1;118(Pt 23):5603-13
pubmed: 16306223
Mol Microbiol. 2011 Sep;81(5):1343-57
pubmed: 21752110
ACS Infect Dis. 2021 Apr 9;7(4):811-825
pubmed: 33715347
Int J Parasitol. 1997 Sep;27(9):989-1006
pubmed: 9363481
Cell Host Microbe. 2012 Nov 15;12(5):682-92
pubmed: 23159057
Parasitology. 1985 Feb;90 ( Pt 1):45-55
pubmed: 3920634
FEBS J. 2012 Jun;279(11):2022-35
pubmed: 22458847
FEMS Microbiol Rev. 2019 Jul 1;43(4):401-414
pubmed: 31220244
Cell Microbiol. 2021 Sep;23(9):e13341
pubmed: 33830607
Malar J. 2012 Jun 12;11:194
pubmed: 22691309
Blood. 2007 Mar 1;109(5):2217-24
pubmed: 17047158
Nat Microbiol. 2018 Oct;3(10):1090-1098
pubmed: 30150733
Molecules. 2020 Jul 13;25(14):
pubmed: 32668631
Nat Commun. 2021 Aug 10;12(1):4806
pubmed: 34376675