Evolutionary conservation and cell type specificity of nuclear compartments in the brain.
human cortex
lamin B
lamina-associated domain (LAD)
spatial genome organization
speckle-associated domain (SPAD)
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
04
10
2021
accepted:
15
10
2021
pubmed:
11
11
2021
medline:
8
4
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
In the cell nucleus, radial genome organization relative to the nuclear lamina exhibits both cell type-specific variability and evolutionarily conserved distribution. A recent study by Ahanger, Delgado et al. explores the in vivo spatial distribution of the genome in the brain and identifies conserved genomic localization across mammalian species that are correlated with gene expression states.
Identifiants
pubmed: 34756461
pii: S0166-2236(21)00205-8
doi: 10.1016/j.tins.2021.10.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-5Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare that they have no competing interests in relation to this work.