Emerging roles of N-linked glycosylation in brain physiology and disorders.
Alzheimer’s disease
N-linked glycosylation
carbohydrate metabolism
neurodegeneration
neuroinflammation
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
27
07
2021
revised:
10
09
2021
accepted:
23
09
2021
pubmed:
11
11
2021
medline:
28
4
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
N-linked glycosylation is a complex, co- and post-translational series of events that connects metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans multiple cellular compartments, and early N-linked glycan biosynthesis is a central mediator of protein folding and the unfolded protein response (UPR). In the brain, N-linked glycosylated proteins participate in a myriad of processes, from electrical gradients to neurotransmission. However, it is less clear how perturbations in N-linked glycosylation impact and even potentially drive aspects of neurological disorders. In this review, we discuss our current understanding of the metabolic origins of N-linked glycans in the brain, their role in modulating neuronal function, and how aberrant N-linked glycosylation can drive neurological disorders.
Identifiants
pubmed: 34756776
pii: S1043-2760(21)00221-6
doi: 10.1016/j.tem.2021.09.006
pmc: PMC8589112
mid: NIHMS1744697
pii:
doi:
Substances chimiques
Polysaccharides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
980-993Subventions
Organisme : NINDS NIH HHS
ID : R35 NS116824
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA165990
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA264165
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS097197
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066653
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests R.C.S. and M.S.G. are consultants for Maze Therapeutics, M.S.G. is a consultant for Enable Therapeutics, Glut1-Deficiency Syndrome Foundation, and Chelsea's Hope. M.S.G. and R.C.S. are founders of Atterogen, LLC.
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