The organization and development of cortical interneuron presynaptic circuits are area specific.

Animals Cerebral Cortex / metabolism Female Fragile X Mental Retardation Protein / physiology Fragile X Syndrome / genetics Interneurons / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Neural Pathways Presynaptic Terminals / metabolism Rabies virus / genetics Sense Organs / metabolism Synapses / metabolism
ALM GABAergic interneurons cortical areas development fragile X syndrome monosynaptic rabies tracing sensory cortex thalamocortical input

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
09 11 2021
Historique:
received: 26 05 2021
revised: 17 08 2021
accepted: 21 10 2021
entrez: 10 11 2021
pubmed: 11 11 2021
medline: 19 2 2022
Statut: ppublish

Résumé

Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory and cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant and are thought to form canonical circuits regardless of which area they are embedded in. Here, we investigate whether this is achieved through selective and systematic variations in their afferent connectivity during development. To this end, we examined the development of their inputs within distinct cortical areas. We find that interneuron afferents show little evidence of being globally stereotyped. Rather, each subtype displays characteristic regional connectivity and distinct developmental dynamics by which this connectivity is achieved. Moreover, afferents dynamically regulated during development are disrupted by early sensory deprivation and in a model of fragile X syndrome. These data provide a comprehensive map of interneuron afferents across cortical areas and reveal the logic by which these circuits are established during development.

Identifiants

DOI: 10.1016/j.celrep.2021.109993 PMID: 34758329 PMC: PMC8832360
pubmed: 34758329
pii: S2211-1247(21)01472-8
doi: 10.1016/j.celrep.2021.109993
pmc: PMC8832360
mid: NIHMS1756262
pii:
doi:

Substances chimiques

Fmr1 protein, mouse 0
Fragile X Mental Retardation Protein 139135-51-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109993

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH071679
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095147
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH071679
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081297
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS039007
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS074972
Pays : United States

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests Gord Fishell is a founder of Regel Therapeutics, which has no competing interests with the present manuscript.

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Auteurs

Gabrielle Pouchelon (G)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA 02142, USA.

Deepanjali Dwivedi (D)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA 02142, USA.

Yannick Bollmann (Y)

Aix Marseille University, INSERM, INMED, Turing Center for Living Systems, Marseille, France.

Chimuanya K Agba (CK)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA 02142, USA.

Qing Xu (Q)

Center for Genomics & Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE.

Andrea M C Mirow (AMC)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA.

Sehyun Kim (S)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA.

Yanjie Qiu (Y)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA 02142, USA.

Elaine Sevier (E)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA 02142, USA.

Kimberly D Ritola (KD)

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Rosa Cossart (R)

Aix Marseille University, INSERM, INMED, Turing Center for Living Systems, Marseille, France.

Gord Fishell (G)

Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA 02142, USA. Electronic address: gordon_fishell@hms.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The organization and development of cortical...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › The organization and development of cortical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéine du syndrome X fragile › The organization and development of cortical...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies neurodégénératives héréditaires › Retard mental lié à l'X › Syndrome du chromosome X fragile › The organization and development of cortical...
questionsmedicales.fr › Cellules › Neurones › Interneurones › The organization and development of cortical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The organization and development of cortical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The organization and development of cortical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › The organization and development of cortical...
questionsmedicales.fr › Système nerveux › Voies nerveuses › The organization and development of cortical...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Terminaisons présynaptiques › The organization and development of cortical...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Rhabdoviridae › Lyssavirus › Virus de la rage › The organization and development of cortical...
questionsmedicales.fr › Organes des sens › The organization and development of cortical...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › The organization and development of cortical...