Systems Approach to Integrating Preclinical Apolipoprotein E-Knockout Investigations Reveals Novel Etiologic Pathways and Master Atherosclerosis Network in Humans.

Adult Aged Animals Apolipoproteins E / deficiency Atherosclerosis / genetics Disease Models, Animal Female Gene Regulatory Networks Genetic Predisposition to Disease Humans Male Mice, Knockout, ApoE Middle Aged Phenotype Plaque, Atherosclerotic Risk Assessment Risk Factors Sex Factors Species Specificity Systems Biology
LXR/RXR TREM1 atherosclerosis cyclooxygenase-2 gene expression

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
01 2022
Historique:
pubmed: 12 11 2021
medline: 18 1 2022
entrez: 11 11 2021
Statut: ppublish

Résumé

Animal models of atherosclerosis are used extensively to interrogate molecular mechanisms in serial fashion. We tested whether a novel systems biology approach to integration of preclinical data identifies novel pathways and regulators in human disease. Approach and Results: Of 716 articles published in PRESCIANT (Preclinical Science Integration and Translation) leverages published preclinical investigations to identify high-confidence pathways, networks, and regulators of human disease.

Identifiants

DOI: 10.1161/ATVBAHA.121.317071 PMID: 34758633 PMC: PMC8887835
pubmed: 34758633
doi: 10.1161/ATVBAHA.121.317071
pmc: PMC8887835
mid: NIHMS1776981
doi:

Substances chimiques

ApoE protein, human 0
Apoe protein, mouse 0
Apolipoproteins E 0

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

35-48

Subventions

Organisme : NCRR NIH HHS
ID : S10 RR025141
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131977
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM066567
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095590
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States

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Auteurs

Megan M Shuey (MM)

Department of Medicine (M.M.S., J.R., Q.S.W., J.A.B.), Vanderbilt University Medical Center, Nashville, TN.

Rachel R Xiang (RR)

Molecular Cardiology Research Institute (R.R.X., M.E.M., B.V.C., Y.W., N.C., A.S., I.Z.J.), Tufts Medical Center, Boston, MA.

M Elizabeth Moss (ME)

Molecular Cardiology Research Institute (R.R.X., M.E.M., B.V.C., Y.W., N.C., A.S., I.Z.J.), Tufts Medical Center, Boston, MA.
ORCID: 0000-0002-9761-7263

Brigett V Carvajal (BV)

Molecular Cardiology Research Institute (R.R.X., M.E.M., B.V.C., Y.W., N.C., A.S., I.Z.J.), Tufts Medical Center, Boston, MA.

Yihua Wang (Y)

Molecular Cardiology Research Institute (R.R.X., M.E.M., B.V.C., Y.W., N.C., A.S., I.Z.J.), Tufts Medical Center, Boston, MA.

Nicholas Camarda (N)

Molecular Cardiology Research Institute (R.R.X., M.E.M., B.V.C., Y.W., N.C., A.S., I.Z.J.), Tufts Medical Center, Boston, MA.
ORCID: 0000-0002-1853-0056

Daniel Fabbri (D)

Department of Biomedical Informatics (D.F., P.R.), Vanderbilt University Medical Center, Nashville, TN.

Protiva Rahman (P)

Department of Biomedical Informatics (D.F., P.R.), Vanderbilt University Medical Center, Nashville, TN.

Jacob Ramsey (J)

Department of Medicine (M.M.S., J.R., Q.S.W., J.A.B.), Vanderbilt University Medical Center, Nashville, TN.
ORCID: 0000-0003-0966-3292

Alec Stepanian (A)

Molecular Cardiology Research Institute (R.R.X., M.E.M., B.V.C., Y.W., N.C., A.S., I.Z.J.), Tufts Medical Center, Boston, MA.
ORCID: 0000-0003-4719-5792

Paola Sebastiani (P)

Institute for Clinical Research and Health Policy Studies (P.S.), Tufts Medical Center, Boston, MA.

Quinn S Wells (QS)

Department of Medicine (M.M.S., J.R., Q.S.W., J.A.B.), Vanderbilt University Medical Center, Nashville, TN.
ORCID: 0000-0003-3899-0313

Joshua A Beckman (JA)

Department of Medicine (M.M.S., J.R., Q.S.W., J.A.B.), Vanderbilt University Medical Center, Nashville, TN.
ORCID: 0000-0001-8332-8439

Iris Z Jaffe (IZ)

Molecular Cardiology Research Institute (R.R.X., M.E.M., B.V.C., Y.W., N.C., A.S., I.Z.J.), Tufts Medical Center, Boston, MA.
ORCID: 0000-0001-9300-1253

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Systems Approach to Integrating Preclinical...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Systems Approach to Integrating Preclinical...
questionsmedicales.fr › Eucaryotes › Animaux › Systems Approach to Integrating Preclinical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Systems Approach to Integrating Preclinical...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Systems Approach to Integrating Preclinical...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Systems Approach to Integrating Preclinical...
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questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Systems Approach to Integrating Preclinical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Systems Approach to Integrating Preclinical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Souris invalidées pour les gènes ApoE › Systems Approach to Integrating Preclinical...
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