Three encephalitis-causing amoebae and their distinct interactions with the host.
Acanthamoeba
Balamuthia mandrillaris
Naegleria fowleri
central nervous system
host–pathogen interactions
immunity
protozoal infections
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
14
05
2021
revised:
11
10
2021
accepted:
18
10
2021
pubmed:
12
11
2021
medline:
9
4
2022
entrez:
11
11
2021
Statut:
ppublish
Résumé
Naegleria fowleri, Balamuthia mandrillaris, and Acanthamoeba spp. can cause devastating brain infections in humans which almost always result in death. The symptoms of the three infections overlap, but brain inflammation and the course of the disease differ, depending on the amoeba that is responsible. Understanding the differences between these amoebae can result in the development of strategies to prevent and treat these infections. Recently, numerous scientific advancements have been made in the understanding of pathogenicity mechanisms in general, and the basic biology, epidemiology, and the human immune response towards these amoebae in particular. In this review, we combine this knowledge and aim to identify which factors can explain the differences between the lethal brain infections caused by N. fowleri, B. mandrillaris, and Acanthamoeba spp.
Identifiants
pubmed: 34758928
pii: S1471-4922(21)00261-0
doi: 10.1016/j.pt.2021.10.004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
230-245Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.