The temporal onset of the core features in dementia with Lewy bodies.
Alzheimer's disease
Lewy body disease
neuropsychiatric
sex
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
01
06
2021
received:
11
12
2020
accepted:
08
06
2021
pubmed:
12
11
2021
medline:
9
4
2022
entrez:
11
11
2021
Statut:
ppublish
Résumé
We examined the temporal sequence of the core features in probable dementia with Lewy bodies (DLB). In 488 patients with probable DLB, the onset of each core feature and time to diagnosis was determined for men and women, and a pathologic subgroup (n = 209). REM sleep behavior disorder (RBD) developed before the other core features in men and women. Men were more likely to have RBD and were diagnosed with probable DLB earlier than women. Visual hallucinations developed after the other core features in men, but in women, they appeared earlier and concurrently with fluctuations and parkinsonism. Women were older and more cognitively impaired at first visit, were less likely to have RBD, more likely to be diagnosed with probable DLB later than men, and more likely to have neocortical tangles. An earlier latency to probable DLB was associated with men, RBD, and Lewy body disease without neocortical tangles.
Identifiants
pubmed: 34761850
doi: 10.1002/alz.12411
pmc: PMC8986606
mid: NIHMS1769695
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
591-601Subventions
Organisme : NIA NIH HHS
ID : P30 AG062677
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS100620
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014942
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063911
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM065841
Pays : United States
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Références
Neurology. 2020 Jul 14;95(2):e155-e165
pubmed: 32561678
Neurology. 2004 Jan 27;62(2):181-7
pubmed: 14745051
Lancet Neurol. 2017 Jan;16(1):55-65
pubmed: 27979356
Sleep. 2019 Oct 9;42(10):
pubmed: 31587043
Parkinsonism Relat Disord. 2013 Jan;19(1):120-2
pubmed: 22726815
Neurology. 2017 Jul 4;89(1):88-100
pubmed: 28592453
Sleep Med Rev. 2019 Feb;43:37-46
pubmed: 30503716
Sleep Med. 2013 Aug;14(8):754-62
pubmed: 23474058
Alzheimers Res Ther. 2020 Oct 29;12(1):137
pubmed: 33121510
Brain Res. 2019 Sep 15;1719:11-16
pubmed: 31128096
Alzheimers Dement. 2022 Apr;18(4):591-601
pubmed: 34761850
Neurology. 2015 Feb 3;84(5):496-9
pubmed: 25552579
Sleep Med. 2020 Feb;66:216-219
pubmed: 31978865
Parkinsonism Relat Disord. 2020 Nov;80:184-193
pubmed: 33260030
Psychogeriatrics. 2020 Sep;20(5):737-745
pubmed: 32743894
Alzheimers Res Ther. 2020 Apr 17;12(1):44
pubmed: 32303272
BJPsych Open. 2020 Jun 16;6(4):e61
pubmed: 32539875
J Alzheimers Dis. 2018;64(2):505-513
pubmed: 29889064
Mov Disord Clin Pract. 2018 Oct 03;5(5):506-511
pubmed: 30515439
J Alzheimers Dis. 2019;67(3):995-1005
pubmed: 30776008
Sleep. 2018 Feb 1;41(2):
pubmed: 29216391
Mov Disord. 2020 Jan;35(1):5-19
pubmed: 31660655
J Neurol Neurosurg Psychiatry. 2008 Dec;79(12):1415-6
pubmed: 19010959
Ann Neurol. 2010 Sep;68(3):353-9
pubmed: 20626046
PLoS One. 2014 Feb 26;9(2):e89741
pubmed: 24587002
Mov Disord. 2012 Jan;27(1):72-8
pubmed: 22038951
Geriatr Gerontol Int. 2015 Jul;15(7):817-26
pubmed: 25690399
J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):358-366
pubmed: 29030419
Int J Geriatr Psychiatry. 2018 Oct;33(10):1293-1304
pubmed: 30091150
Neurology. 2020 Apr 28;94(17):743-755
pubmed: 32241955
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
Psychopharmacol Bull. 1988;24(4):661-3
pubmed: 3249768
Sleep Med. 2015 Mar;16(3):414-8
pubmed: 25660814
Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S30-S33
pubmed: 28780180
Acta Neuropathol. 2016 Mar;131(3):393-409
pubmed: 26721587
Dement Geriatr Cogn Dis Extra. 2015 Nov 24;5(3):442-9
pubmed: 26674638
Front Neuroendocrinol. 2018 Jul;50:18-30
pubmed: 28974386
J Clin Sleep Med. 2019 Dec 15;15(12):1789-1798
pubmed: 31855164
Brain. 2019 Jul 1;142(7):2051-2067
pubmed: 31111143
Alzheimers Res Ther. 2018 Feb 15;10(1):19
pubmed: 29448953
J Alzheimers Dis. 2019;70(2):389-397
pubmed: 31177218
Parkinsonism Relat Disord. 2016 Oct;31:72-78
pubmed: 27475955
J Neurol. 2010 Nov;257(11):1875-81
pubmed: 20563821
Mov Disord. 2007 Sep 15;22(12):1689-707; quiz 1837
pubmed: 17542011
Acta Neuropathol. 2019 Nov;138(5):771-782
pubmed: 31494694
J Parkinsons Dis. 2019;9(3):501-515
pubmed: 31282427
JAMA Neurol. 2017 Mar 01;74(3):310-315
pubmed: 28114455
J Neuropathol Exp Neurol. 2006 Jul;65(7):685-97
pubmed: 16825955
J Neurosci. 2017 Feb 15;37(7):1675-1684
pubmed: 28039370
Alzheimers Dement (Amst). 2015 Sep 1;1(3):316-324
pubmed: 26405688
Acta Neuropathol. 2020 Jun;139(6):977-1000
pubmed: 32356200
J Neurol Neurosurg Psychiatry. 2021 Jul;92(7):745-750
pubmed: 33563809
Int J Geriatr Psychiatry. 2014 Feb;29(2):178-81
pubmed: 23722989
Trends Neurosci. 2017 Jan;40(1):4-14
pubmed: 27894611
Ann Neurol. 2018 May;83(5):1016-1026
pubmed: 29665124
Int J Geriatr Psychiatry. 2018 Jan;33(1):193-199
pubmed: 28295599
Lancet Neurol. 2020 Feb;19(2):157-169
pubmed: 31519472
Brain. 2019 Mar 1;142(3):744-759
pubmed: 30789229
Psychol Med. 2018 Oct;48(14):2384-2390
pubmed: 29362011